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alpha-Trinositol inhibits FGF-stimulated growth of smooth muscle and breast cancer cells

Siren, MJ; Vainiomaki, M; Vaananen, K and Härkönen, Pirkko LU (2004) In Biochemical and Biophysical Research Communications 325(3). p.691-697
Abstract
alpha-Trinositol (D-myo-inositol-1,2,6-trisphosphate), an isomer of the intracellular messenger IP3, has been studied for its anti-inflammatory and other effects in animal experiments and in human. The mechanisms of action remain unknown. Several human pathologies are associated with uncontrolled production of fibroblast growth factors (FGFs). FGF-2 induces vascular smooth muscle cell proliferation, which contributes to restenosis after coronary balloon angioplasty. The expression of several FGFs is also increased in tumors. We studied the effects of the water- and lipid-soluble derivatives of alpha-trinositol on the FGF-2- and/or FGF-8-induced proliferation of human pulmonary artery smooth muscle cells (HPASMC) and 5115 mouse breast... (More)
alpha-Trinositol (D-myo-inositol-1,2,6-trisphosphate), an isomer of the intracellular messenger IP3, has been studied for its anti-inflammatory and other effects in animal experiments and in human. The mechanisms of action remain unknown. Several human pathologies are associated with uncontrolled production of fibroblast growth factors (FGFs). FGF-2 induces vascular smooth muscle cell proliferation, which contributes to restenosis after coronary balloon angioplasty. The expression of several FGFs is also increased in tumors. We studied the effects of the water- and lipid-soluble derivatives of alpha-trinositol on the FGF-2- and/or FGF-8-induced proliferation of human pulmonary artery smooth muscle cells (HPASMC) and 5115 mouse breast cancer cells. a-Trinositol decreased the FGF-mediated proliferation of HPASMC and 5115 cells. Membrane permeability did not seem obligatory since the lipid-soluble form of alpha-trinositol was less effective than the water-soluble derivative. These results suggest a new biological function for certain phosphoinositides in the modulation of FGF-regulated processes. (C) 2004 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HPASMC, alpha-trinositol, FGFs, S115 cells
in
Biochemical and Biophysical Research Communications
volume
325
issue
3
pages
691 - 697
publisher
Elsevier
external identifiers
  • pmid:15541344
  • wos:000225350300008
  • scopus:8444241492
ISSN
1090-2104
DOI
10.1016/j.bbrc.2004.10.087
language
English
LU publication?
yes
id
29653a45-3300-4242-9d00-1932b45fa071 (old id 259769)
date added to LUP
2007-10-31 15:22:48
date last changed
2017-01-01 07:18:22
@article{29653a45-3300-4242-9d00-1932b45fa071,
  abstract     = {alpha-Trinositol (D-myo-inositol-1,2,6-trisphosphate), an isomer of the intracellular messenger IP3, has been studied for its anti-inflammatory and other effects in animal experiments and in human. The mechanisms of action remain unknown. Several human pathologies are associated with uncontrolled production of fibroblast growth factors (FGFs). FGF-2 induces vascular smooth muscle cell proliferation, which contributes to restenosis after coronary balloon angioplasty. The expression of several FGFs is also increased in tumors. We studied the effects of the water- and lipid-soluble derivatives of alpha-trinositol on the FGF-2- and/or FGF-8-induced proliferation of human pulmonary artery smooth muscle cells (HPASMC) and 5115 mouse breast cancer cells. a-Trinositol decreased the FGF-mediated proliferation of HPASMC and 5115 cells. Membrane permeability did not seem obligatory since the lipid-soluble form of alpha-trinositol was less effective than the water-soluble derivative. These results suggest a new biological function for certain phosphoinositides in the modulation of FGF-regulated processes. (C) 2004 Elsevier Inc. All rights reserved.},
  author       = {Siren, MJ and Vainiomaki, M and Vaananen, K and Härkönen, Pirkko},
  issn         = {1090-2104},
  keyword      = {HPASMC,alpha-trinositol,FGFs,S115 cells},
  language     = {eng},
  number       = {3},
  pages        = {691--697},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {alpha-Trinositol inhibits FGF-stimulated growth of smooth muscle and breast cancer cells},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2004.10.087},
  volume       = {325},
  year         = {2004},
}