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The association of zonulin-related proteins with prevalent and incident inflammatory bowel disease

Wang, Xiao LU ; Memon, Ashfaque A LU orcid ; Palmér, Karolina LU ; Hedelius, Anna LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2022) In BMC Gastroenterology 22(1).
Abstract

BACKGROUND: Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.

METHOD: The study included a total of 130 women (51-61 years) from the Women's Health in Lund Area (WHILA) study, which included 18 prevalent IBD (diagnosed before baseline) and 47 incident IBD diagnosed during the 17 years (median) follow-up and age- and sampling time-matched controls. Serum ZRP was tested in all participants by ELISA.

RESULTS: The serum ZRP levels... (More)

BACKGROUND: Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.

METHOD: The study included a total of 130 women (51-61 years) from the Women's Health in Lund Area (WHILA) study, which included 18 prevalent IBD (diagnosed before baseline) and 47 incident IBD diagnosed during the 17 years (median) follow-up and age- and sampling time-matched controls. Serum ZRP was tested in all participants by ELISA.

RESULTS: The serum ZRP levels were significantly higher in prevalent IBD compared to their matched controls (63.2 ng/ml vs 57.0 ng/ml, p = 0.02), however, no evidence of a difference in ZRP levels was found between the women who developed IBD during the follow-up period and their matched controls (61.2 ng/ml vs 59.7 ng/ml, p = 0.34). Using linear mixed models, we found that the association between serum ZRP levels and prevalent IBD (β = 6.2, p = 0.01), remained after adjusting for potential confounders. Conditional logistic regression models showed no evidence of an association between ZRP level and incident IBD (OR 1.03, p = 0.34).

CONCLUSION: Higher serum ZRP levels were associated with prevalent IBD, but not with incident IBD in our study samples.

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Please use this url to cite or link to this publication:
author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colitis, Colitis, Ulcerative, Female, Haptoglobins, Humans, Inflammatory Bowel Diseases/epidemiology, Logistic Models, Protein Precursors
in
BMC Gastroenterology
volume
22
issue
1
article number
3
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85122321981
  • pmid:34979917
ISSN
1471-230X
DOI
10.1186/s12876-021-02075-y
language
English
LU publication?
yes
additional info
© 2022. The Author(s).
id
25af5344-4a33-4fd1-a4df-ec57c88df7b3
date added to LUP
2022-01-13 15:42:23
date last changed
2024-04-20 18:59:05
@article{25af5344-4a33-4fd1-a4df-ec57c88df7b3,
  abstract     = {{<p>BACKGROUND: Current evidence regarding the association of serum zonulin-related proteins (ZRP) levels with prevalent inflammatory bowel disease (IBD) is contradictory. Moreover, the association with the subsequent risk of incident IBD is still unexplored. This study aimed to investigate the association of serum ZRP levels with both prevalent and incident IBD.</p><p>METHOD: The study included a total of 130 women (51-61 years) from the Women's Health in Lund Area (WHILA) study, which included 18 prevalent IBD (diagnosed before baseline) and 47 incident IBD diagnosed during the 17 years (median) follow-up and age- and sampling time-matched controls. Serum ZRP was tested in all participants by ELISA.</p><p>RESULTS: The serum ZRP levels were significantly higher in prevalent IBD compared to their matched controls (63.2 ng/ml vs 57.0 ng/ml, p = 0.02), however, no evidence of a difference in ZRP levels was found between the women who developed IBD during the follow-up period and their matched controls (61.2 ng/ml vs 59.7 ng/ml, p = 0.34). Using linear mixed models, we found that the association between serum ZRP levels and prevalent IBD (β = 6.2, p = 0.01), remained after adjusting for potential confounders. Conditional logistic regression models showed no evidence of an association between ZRP level and incident IBD (OR 1.03, p = 0.34).</p><p>CONCLUSION: Higher serum ZRP levels were associated with prevalent IBD, but not with incident IBD in our study samples.</p>}},
  author       = {{Wang, Xiao and Memon, Ashfaque A and Palmér, Karolina and Hedelius, Anna and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{1471-230X}},
  keywords     = {{Colitis; Colitis, Ulcerative; Female; Haptoglobins; Humans; Inflammatory Bowel Diseases/epidemiology; Logistic Models; Protein Precursors}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Gastroenterology}},
  title        = {{The association of zonulin-related proteins with prevalent and incident inflammatory bowel disease}},
  url          = {{http://dx.doi.org/10.1186/s12876-021-02075-y}},
  doi          = {{10.1186/s12876-021-02075-y}},
  volume       = {{22}},
  year         = {{2022}},
}