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Equivalent fully coupled modeling and experimental validation of high-particle-concentration acoustofluidics

Xu, Duo LU ; Qiu, Wei LU orcid ; Lv, Zengyao and Pei, Yongmao (2025) In Physics of Fluids 37(12).
Abstract
Acoustofluidic particle manipulation has attracted considerable interest in biomedical applications due to its non-contact and label-free characteristics. However, existing computational models for predicting particle motion in acoustofluidic systems mainly focus on single-particle behavior, often neglecting particle–particle interactions and the impact of particle distribution on the acoustic and flow fields at high concentrations. To address these limitations, we propose an equivalent fully coupled model for the acoustofluidic manipulation of highly concentrated particle suspensions. Utilizing a two-phase flow framework, the suspension is modeled as an equivalent continuous medium, enabling the calculation of the effective acoustic field... (More)
Acoustofluidic particle manipulation has attracted considerable interest in biomedical applications due to its non-contact and label-free characteristics. However, existing computational models for predicting particle motion in acoustofluidic systems mainly focus on single-particle behavior, often neglecting particle–particle interactions and the impact of particle distribution on the acoustic and flow fields at high concentrations. To address these limitations, we propose an equivalent fully coupled model for the acoustofluidic manipulation of highly concentrated particle suspensions. Utilizing a two-phase flow framework, the suspension is modeled as an equivalent continuous medium, enabling the calculation of the effective acoustic field and the prediction of the motion and spatial distribution of both phases. Full coupling among the acoustic, fluid, and particle fields is achieved through iterative parameterization. The model is employed to investigate the dynamics of particles both above and near the critical size, with experimental validation conducted in both regimes. The results underscore the necessity of fully coupled modeling under high-concentration conditions. Moreover, a novel focusing state is identified for particles near the critical size, and its underlying mechanism is thoroughly analyzed. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physics of Fluids
volume
37
issue
12
article number
122007
pages
10 pages
publisher
American Institute of Physics (AIP)
ISSN
1089-7666
DOI
10.1063/5.0288875
language
English
LU publication?
yes
id
25be793f-18dc-4158-b738-b2c967b0b0e3
date added to LUP
2025-12-05 00:23:32
date last changed
2025-12-08 13:24:08
@article{25be793f-18dc-4158-b738-b2c967b0b0e3,
  abstract     = {{Acoustofluidic particle manipulation has attracted considerable interest in biomedical applications due to its non-contact and label-free characteristics. However, existing computational models for predicting particle motion in acoustofluidic systems mainly focus on single-particle behavior, often neglecting particle–particle interactions and the impact of particle distribution on the acoustic and flow fields at high concentrations. To address these limitations, we propose an equivalent fully coupled model for the acoustofluidic manipulation of highly concentrated particle suspensions. Utilizing a two-phase flow framework, the suspension is modeled as an equivalent continuous medium, enabling the calculation of the effective acoustic field and the prediction of the motion and spatial distribution of both phases. Full coupling among the acoustic, fluid, and particle fields is achieved through iterative parameterization. The model is employed to investigate the dynamics of particles both above and near the critical size, with experimental validation conducted in both regimes. The results underscore the necessity of fully coupled modeling under high-concentration conditions. Moreover, a novel focusing state is identified for particles near the critical size, and its underlying mechanism is thoroughly analyzed.}},
  author       = {{Xu, Duo and Qiu, Wei and Lv, Zengyao and Pei, Yongmao}},
  issn         = {{1089-7666}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{12}},
  publisher    = {{American Institute of Physics (AIP)}},
  series       = {{Physics of Fluids}},
  title        = {{Equivalent fully coupled modeling and experimental validation of high-particle-concentration acoustofluidics}},
  url          = {{http://dx.doi.org/10.1063/5.0288875}},
  doi          = {{10.1063/5.0288875}},
  volume       = {{37}},
  year         = {{2025}},
}