Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes
(2023) In Diabetes Care 46(11). p.1993-1996- Abstract
- OBJECTIVE
To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.
RESEARCH DESIGN AND METHODS
A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.
RESULTS
Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P < 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P < 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P < 0.001), and less likely to be positive... (More) - OBJECTIVE
To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.
RESEARCH DESIGN AND METHODS
A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.
RESULTS
Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P < 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P < 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P < 0.001), and less likely to be positive for IAA (32.3% vs. 33.8%; P = 0.016). Small sex differences in HLA risk were found in children CONCLUSIONS
The disease mechanisms leading to T1D may influence the immune system differently in girls and boys.
(Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/25c6280f-c1b9-48dc-b196-2235066788d6
- author
- organization
- publishing date
- 2023-09-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Diabetes Care
- volume
- 46
- issue
- 11
- pages
- 1993 - 1996
- publisher
- American Diabetes Association
- external identifiers
-
- pmid:37699205
- scopus:85175356329
- ISSN
- 1935-5548
- DOI
- 10.2337/dc23-0124
- language
- English
- LU publication?
- yes
- id
- 25c6280f-c1b9-48dc-b196-2235066788d6
- date added to LUP
- 2023-10-17 08:35:54
- date last changed
- 2024-04-20 07:35:00
@article{25c6280f-c1b9-48dc-b196-2235066788d6, abstract = {{OBJECTIVE<br/>To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.<br/>RESEARCH DESIGN AND METHODS<br/>A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.<br/>RESULTS<br/>Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P < 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P < 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P < 0.001), and less likely to be positive for IAA (32.3% vs. 33.8%; P = 0.016). Small sex differences in HLA risk were found in children CONCLUSIONS<br/>The disease mechanisms leading to T1D may influence the immune system differently in girls and boys.<br/>}}, author = {{Tojjar, Jasaman and Cervin, Matti and Hedlund, Emma and Brahimi, Qefsere and Forsander, Gun and Elding Larsson, Helena and Ludvigsson, Johnny and Samuelsson, Ulf and Marcus, Claude and Persson, Martina and Carlsson, Annelie}}, issn = {{1935-5548}}, language = {{eng}}, month = {{09}}, number = {{11}}, pages = {{1993--1996}}, publisher = {{American Diabetes Association}}, series = {{Diabetes Care}}, title = {{Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes}}, url = {{http://dx.doi.org/10.2337/dc23-0124}}, doi = {{10.2337/dc23-0124}}, volume = {{46}}, year = {{2023}}, }