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Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes

Tojjar, Jasaman LU ; Cervin, Matti LU ; Hedlund, Emma LU ; Brahimi, Qefsere LU ; Forsander, Gun ; Elding Larsson, Helena LU ; Ludvigsson, Johnny ; Samuelsson, Ulf ; Marcus, Claude and Persson, Martina , et al. (2023) In Diabetes Care 46(11). p.1993-1996
Abstract
OBJECTIVE
To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.
RESEARCH DESIGN AND METHODS
A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.
RESULTS
Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P < 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P < 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P < 0.001), and less likely to be positive... (More)
OBJECTIVE
To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.
RESEARCH DESIGN AND METHODS
A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.
RESULTS
Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P < 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P < 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P < 0.001), and less likely to be positive for IAA (32.3% vs. 33.8%; P = 0.016). Small sex differences in HLA risk were found in children CONCLUSIONS
The disease mechanisms leading to T1D may influence the immune system differently in girls and boys.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetes Care
volume
46
issue
11
pages
1993 - 1996
publisher
American Diabetes Association
external identifiers
  • pmid:37699205
  • scopus:85175356329
ISSN
1935-5548
DOI
10.2337/dc23-0124
language
English
LU publication?
yes
id
25c6280f-c1b9-48dc-b196-2235066788d6
date added to LUP
2023-10-17 08:35:54
date last changed
2024-04-20 07:35:00
@article{25c6280f-c1b9-48dc-b196-2235066788d6,
  abstract     = {{OBJECTIVE<br/>To examine sex differences in children with newly diagnosed type 1 diabetes (T1D) with respect to age at diagnosis, presence of autoantibodies (GAD antibody [GADA], insulinoma-associated protein 2 [IA-2A], insulin autoantibody [IAA], and zinc transporter 8 autoantibody), and HLA risk.<br/>RESEARCH DESIGN AND METHODS<br/>A population-based nationwide sample of 3,645 Swedish children at T1D diagnosis was used.<br/>RESULTS<br/>Girls were younger at T1D diagnosis (9.53 vs. 10.23 years; P &lt; 0.001), more likely to be autoantibody-positive (94.7% vs. 92.0%; P = 0.002), more often positive for multiple autoantibodies (P &lt; 0.001), more likely to be positive for GADA (64.9% vs. 49.0%; P &lt; 0.001), and less likely to be positive for IAA (32.3% vs. 33.8%; P = 0.016). Small sex differences in HLA risk were found in children CONCLUSIONS<br/>The disease mechanisms leading to T1D may influence the immune system differently in girls and boys.<br/>}},
  author       = {{Tojjar, Jasaman and Cervin, Matti and Hedlund, Emma and Brahimi, Qefsere and Forsander, Gun and Elding Larsson, Helena and Ludvigsson, Johnny and Samuelsson, Ulf and Marcus, Claude and Persson, Martina and Carlsson, Annelie}},
  issn         = {{1935-5548}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{11}},
  pages        = {{1993--1996}},
  publisher    = {{American Diabetes Association}},
  series       = {{Diabetes Care}},
  title        = {{Sex Differences in Age of Diagnosis, HLA Genotype, and Autoantibody Profile in Children With Type 1 Diabetes}},
  url          = {{http://dx.doi.org/10.2337/dc23-0124}},
  doi          = {{10.2337/dc23-0124}},
  volume       = {{46}},
  year         = {{2023}},
}