Advanced

Myocardium at risk by magnetic resonance imaging: head-to-head comparison of T2-weighted imaging and contrast-enhanced steady-state free precession.

Ubachs, Joey LU ; Sörensson, Peder; Engblom, Henrik LU ; Carlsson, Marcus LU ; Jovinge, Stefan LU ; Pernow, John and Arheden, Håkan LU (2012) In European Heart Journal-Cardiovascular Imaging
Abstract
AIMS:

To determine the myocardial salvage index, the extent of infarction needs to be related to the myocardium at risk (MaR). Thus, the ability to assess both infarct size and MaR is of central clinical and scientific importance. The aim of the present study was to explore the relationship between T2-weighted cardiac magnetic resonance (CMR) and contrast-enhanced steady-state free precession (CE-SSFP) CMR for the determination of MaR in patients with acute myocardial infarction.



METHODS AND RESULTS:

Twenty-one prospectively included patients with first-time ST-elevation myocardial infarction underwent CMR 1 week after primary percutaneous coronary intervention. For the assessment of MaR, T2-weighted... (More)
AIMS:

To determine the myocardial salvage index, the extent of infarction needs to be related to the myocardium at risk (MaR). Thus, the ability to assess both infarct size and MaR is of central clinical and scientific importance. The aim of the present study was to explore the relationship between T2-weighted cardiac magnetic resonance (CMR) and contrast-enhanced steady-state free precession (CE-SSFP) CMR for the determination of MaR in patients with acute myocardial infarction.



METHODS AND RESULTS:

Twenty-one prospectively included patients with first-time ST-elevation myocardial infarction underwent CMR 1 week after primary percutaneous coronary intervention. For the assessment of MaR, T2-weighted images were acquired before and CE-SSFP images were acquired after the injection of a gadolinium-based contrast agent. For the assessment of infarct size, late gadolinium enhancement images were acquired. The MaR by T2-weighted imaging and CE-SSFP was 29 ± 11 and 32 ± 12% of the left ventricle, respectively. Thus, the MaR with T2-weighted imaging was slightly smaller than that by CE-SSFP (-3.0 ± 4.0%; P < 0.01). There was a significant correlation between the two MaR measures (r(2)= 0.89, P < 0.01), independent of the time after contrast agent administration at which the CE-SSFP was commenced (2-8 min).



CONCLUSION:

There is a good agreement between the MaR assessed by T2-weighted imaging and that assessed by CE-SSFP in patients with reperfused acute myocardial infarction 1 week after the acute event. Thus, both methods can be used to determine MaR and myocardial salvage at this point in time. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Heart Journal-Cardiovascular Imaging
publisher
Oxford University Press
external identifiers
  • wos:000311307300008
  • pmid:22645203
  • scopus:84869460966
ISSN
2047-2412
DOI
10.1093/ehjci/jes091
language
English
LU publication?
yes
id
1b5b17d9-4620-4477-a87f-f11d1443c7e9 (old id 2608301)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22645203?dopt=Abstract
date added to LUP
2012-06-04 21:10:27
date last changed
2017-09-24 04:38:29
@article{1b5b17d9-4620-4477-a87f-f11d1443c7e9,
  abstract     = {AIMS: <br/><br>
To determine the myocardial salvage index, the extent of infarction needs to be related to the myocardium at risk (MaR). Thus, the ability to assess both infarct size and MaR is of central clinical and scientific importance. The aim of the present study was to explore the relationship between T2-weighted cardiac magnetic resonance (CMR) and contrast-enhanced steady-state free precession (CE-SSFP) CMR for the determination of MaR in patients with acute myocardial infarction. <br/><br>
<br/><br>
METHODS AND RESULTS: <br/><br>
Twenty-one prospectively included patients with first-time ST-elevation myocardial infarction underwent CMR 1 week after primary percutaneous coronary intervention. For the assessment of MaR, T2-weighted images were acquired before and CE-SSFP images were acquired after the injection of a gadolinium-based contrast agent. For the assessment of infarct size, late gadolinium enhancement images were acquired. The MaR by T2-weighted imaging and CE-SSFP was 29 ± 11 and 32 ± 12% of the left ventricle, respectively. Thus, the MaR with T2-weighted imaging was slightly smaller than that by CE-SSFP (-3.0 ± 4.0%; P &lt; 0.01). There was a significant correlation between the two MaR measures (r(2)= 0.89, P &lt; 0.01), independent of the time after contrast agent administration at which the CE-SSFP was commenced (2-8 min). <br/><br>
<br/><br>
CONCLUSION: <br/><br>
There is a good agreement between the MaR assessed by T2-weighted imaging and that assessed by CE-SSFP in patients with reperfused acute myocardial infarction 1 week after the acute event. Thus, both methods can be used to determine MaR and myocardial salvage at this point in time.},
  author       = {Ubachs, Joey and Sörensson, Peder and Engblom, Henrik and Carlsson, Marcus and Jovinge, Stefan and Pernow, John and Arheden, Håkan},
  issn         = {2047-2412},
  language     = {eng},
  month        = {05},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal-Cardiovascular Imaging},
  title        = {Myocardium at risk by magnetic resonance imaging: head-to-head comparison of T2-weighted imaging and contrast-enhanced steady-state free precession.},
  url          = {http://dx.doi.org/10.1093/ehjci/jes091},
  year         = {2012},
}