Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen.
(2012) In Cancer Discovery 2(4). p.320-327- Abstract
- Despite intense efforts to develop radiotracers to detect cancers or monitor treatment response, few are widely used as a result of challenges with demonstrating clear clinical use. We reasoned that a radiotracer targeting a validated clinical biomarker could more clearly assess the advantages of imaging cancer. The virtues and shortcomings of measuring secreted prostate-specific antigen (PSA), an androgen receptor (AR) target gene, in patients with prostate cancer are well documented, making it a logical candidate for assessing whether a radiotracer can reveal new (and useful) information beyond that conferred by serum PSA. Therefore, we developed (89)Zr-labeled 5A10, a novel radiotracer that targets "free" PSA. (89)Zr-5A10 localizes in... (More)
- Despite intense efforts to develop radiotracers to detect cancers or monitor treatment response, few are widely used as a result of challenges with demonstrating clear clinical use. We reasoned that a radiotracer targeting a validated clinical biomarker could more clearly assess the advantages of imaging cancer. The virtues and shortcomings of measuring secreted prostate-specific antigen (PSA), an androgen receptor (AR) target gene, in patients with prostate cancer are well documented, making it a logical candidate for assessing whether a radiotracer can reveal new (and useful) information beyond that conferred by serum PSA. Therefore, we developed (89)Zr-labeled 5A10, a novel radiotracer that targets "free" PSA. (89)Zr-5A10 localizes in an AR-dependent manner in vivo to models of castration-resistant prostate cancer, a disease state in which serum PSA may not reflect clinical outcomes. Finally, we demonstrate that (89)Zr-5A10 can detect osseous prostate cancer lesions, a context where bone scans fail to discriminate malignant and nonmalignant signals. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2608922
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Discovery
- volume
- 2
- issue
- 4
- pages
- 320 - 327
- publisher
- American Association for Cancer Research
- external identifiers
-
- wos:000306327000026
- pmid:22576209
- scopus:84866146188
- ISSN
- 2159-8274
- DOI
- 10.1158/2159-8290.CD-11-0316
- language
- English
- LU publication?
- yes
- id
- 9ccc0ce4-5a56-4d6a-b51d-15109b815792 (old id 2608922)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22576209?dopt=Abstract
- date added to LUP
- 2016-04-04 08:55:43
- date last changed
- 2022-05-16 22:23:16
@article{9ccc0ce4-5a56-4d6a-b51d-15109b815792, abstract = {{Despite intense efforts to develop radiotracers to detect cancers or monitor treatment response, few are widely used as a result of challenges with demonstrating clear clinical use. We reasoned that a radiotracer targeting a validated clinical biomarker could more clearly assess the advantages of imaging cancer. The virtues and shortcomings of measuring secreted prostate-specific antigen (PSA), an androgen receptor (AR) target gene, in patients with prostate cancer are well documented, making it a logical candidate for assessing whether a radiotracer can reveal new (and useful) information beyond that conferred by serum PSA. Therefore, we developed (89)Zr-labeled 5A10, a novel radiotracer that targets "free" PSA. (89)Zr-5A10 localizes in an AR-dependent manner in vivo to models of castration-resistant prostate cancer, a disease state in which serum PSA may not reflect clinical outcomes. Finally, we demonstrate that (89)Zr-5A10 can detect osseous prostate cancer lesions, a context where bone scans fail to discriminate malignant and nonmalignant signals.}}, author = {{Ulmert, David and Evans, Michael J and Holland, Jason P and Rice, Samuel L and Wongvipat, John and Pettersson, Kim and Abrahamsson, Per-Anders and Scardino, Peter T and Larson, Steven M and Lilja, Hans and Lewis, Jason S and Sawyers, Charles L}}, issn = {{2159-8274}}, language = {{eng}}, number = {{4}}, pages = {{320--327}}, publisher = {{American Association for Cancer Research}}, series = {{Cancer Discovery}}, title = {{Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen.}}, url = {{http://dx.doi.org/10.1158/2159-8290.CD-11-0316}}, doi = {{10.1158/2159-8290.CD-11-0316}}, volume = {{2}}, year = {{2012}}, }