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Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen.

Ulmert, David LU ; Evans, Michael J; Holland, Jason P; Rice, Samuel L; Wongvipat, John; Pettersson, Kim; Abrahamsson, Per-Anders LU ; Scardino, Peter T; Larson, Steven M and Lilja, Hans LU , et al. (2012) In Cancer Discovery 2(4). p.320-327
Abstract
Despite intense efforts to develop radiotracers to detect cancers or monitor treatment response, few are widely used as a result of challenges with demonstrating clear clinical use. We reasoned that a radiotracer targeting a validated clinical biomarker could more clearly assess the advantages of imaging cancer. The virtues and shortcomings of measuring secreted prostate-specific antigen (PSA), an androgen receptor (AR) target gene, in patients with prostate cancer are well documented, making it a logical candidate for assessing whether a radiotracer can reveal new (and useful) information beyond that conferred by serum PSA. Therefore, we developed (89)Zr-labeled 5A10, a novel radiotracer that targets "free" PSA. (89)Zr-5A10 localizes in... (More)
Despite intense efforts to develop radiotracers to detect cancers or monitor treatment response, few are widely used as a result of challenges with demonstrating clear clinical use. We reasoned that a radiotracer targeting a validated clinical biomarker could more clearly assess the advantages of imaging cancer. The virtues and shortcomings of measuring secreted prostate-specific antigen (PSA), an androgen receptor (AR) target gene, in patients with prostate cancer are well documented, making it a logical candidate for assessing whether a radiotracer can reveal new (and useful) information beyond that conferred by serum PSA. Therefore, we developed (89)Zr-labeled 5A10, a novel radiotracer that targets "free" PSA. (89)Zr-5A10 localizes in an AR-dependent manner in vivo to models of castration-resistant prostate cancer, a disease state in which serum PSA may not reflect clinical outcomes. Finally, we demonstrate that (89)Zr-5A10 can detect osseous prostate cancer lesions, a context where bone scans fail to discriminate malignant and nonmalignant signals. (Less)
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type
Contribution to journal
publication status
published
subject
in
Cancer Discovery
volume
2
issue
4
pages
320 - 327
publisher
American Association for Cancer Research
external identifiers
  • wos:000306327000026
  • pmid:22576209
  • scopus:84866146188
ISSN
2159-8274
DOI
10.1158/2159-8290.CD-11-0316
language
English
LU publication?
yes
id
9ccc0ce4-5a56-4d6a-b51d-15109b815792 (old id 2608922)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22576209?dopt=Abstract
date added to LUP
2012-06-03 16:20:23
date last changed
2017-07-02 04:36:06
@article{9ccc0ce4-5a56-4d6a-b51d-15109b815792,
  abstract     = {Despite intense efforts to develop radiotracers to detect cancers or monitor treatment response, few are widely used as a result of challenges with demonstrating clear clinical use. We reasoned that a radiotracer targeting a validated clinical biomarker could more clearly assess the advantages of imaging cancer. The virtues and shortcomings of measuring secreted prostate-specific antigen (PSA), an androgen receptor (AR) target gene, in patients with prostate cancer are well documented, making it a logical candidate for assessing whether a radiotracer can reveal new (and useful) information beyond that conferred by serum PSA. Therefore, we developed (89)Zr-labeled 5A10, a novel radiotracer that targets "free" PSA. (89)Zr-5A10 localizes in an AR-dependent manner in vivo to models of castration-resistant prostate cancer, a disease state in which serum PSA may not reflect clinical outcomes. Finally, we demonstrate that (89)Zr-5A10 can detect osseous prostate cancer lesions, a context where bone scans fail to discriminate malignant and nonmalignant signals.},
  author       = {Ulmert, David and Evans, Michael J and Holland, Jason P and Rice, Samuel L and Wongvipat, John and Pettersson, Kim and Abrahamsson, Per-Anders and Scardino, Peter T and Larson, Steven M and Lilja, Hans and Lewis, Jason S and Sawyers, Charles L},
  issn         = {2159-8274},
  language     = {eng},
  number       = {4},
  pages        = {320--327},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Discovery},
  title        = {Imaging androgen receptor signaling with a radiotracer targeting free prostate-specific antigen.},
  url          = {http://dx.doi.org/10.1158/2159-8290.CD-11-0316},
  volume       = {2},
  year         = {2012},
}