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Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility.

Hammar, Oskar LU ; Veress, Bela; Montgomery, Agneta LU and Ohlsson, Bodil LU (2012) In Drug Target Insights 6. p.13-18
Abstract
Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients... (More)
Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Drug Target Insights
volume
6
pages
13 - 18
publisher
Libertas Academica
external identifiers
  • pmid:22563234
  • scopus:84860853549
ISSN
1177-3928
DOI
10.4137/DTI.S9324
language
English
LU publication?
yes
id
86861c99-1724-49b3-a25c-a09537f59f7d (old id 2609082)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22563234?dopt=Abstract
date added to LUP
2012-06-03 12:50:47
date last changed
2017-07-02 04:01:11
@article{86861c99-1724-49b3-a25c-a09537f59f7d,
  abstract     = {Leuprolide is a gonadotropin-releasing hormone (GnRH) analog which has been shown to reduce symptoms in patients with irritable bowel syndrome (IBS) and chronic intestinal pseudo-obstruction (CIPO). The mechanism is not known, but one hypothesis is through down-modulation of luteinizing hormone (LH) secretion, a hormone whith antagonistic effect on gastrointestinal motility. However, presence of LH receptors in the gastrointestinal tract has never been described. The aim of this study was to find one possible way of action for leuprolide by examining the presence of the LH receptor, and if present, to see whether there was different expression in patients with or without dysmotility. Full-thickness biopsies from the bowel wall of patients with and without severe dysmotility were examined using immunohistochemistry staining. Biopsies showed expression of LH receptors on myenteric neurons and in glial cells, neutrophils, endothelial cells and mast cells. There was no difference in expression between patient groups.},
  author       = {Hammar, Oskar and Veress, Bela and Montgomery, Agneta and Ohlsson, Bodil},
  issn         = {1177-3928},
  language     = {eng},
  pages        = {13--18},
  publisher    = {Libertas Academica},
  series       = {Drug Target Insights},
  title        = {Expression of Luteinizing Hormone Receptor in the Gastrointestinal Tract in Patients with and without Dysmotility.},
  url          = {http://dx.doi.org/10.4137/DTI.S9324},
  volume       = {6},
  year         = {2012},
}