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Visibility of microcalcification clusters and masses in breast tomosynthesis image volumes and digital mammography: A 4AFC human observer study.

Timberg, Pontus LU ; Båth, M; Andersson, Ingvar LU ; Mattsson, Sören LU ; Tingberg, Anders LU and Ruschin, Mark (2012) In Medical Physics 39(5). p.2431-2437
Abstract
Purpose:

To investigate the visibility of simulated lesions in digital breast tomosynthesis (BT) image volumes compared with 2D digital mammography (DM).



Methods:

Simulated lesions (masses and microcalcifications) were added to images of the same women acquired on a DM system (Mammomat Novation, Siemens) and a BT prototype. The same beam quality was used for the DM and BT acquisitions. The total absorbed dose resulting from a 25-projection BT acquisition and reconstruction (BT(25)) was approximately twice that of a single DM view. By excluding every other projection image from the reconstruction (BT(13)), approximately the same dose as in DM was effected. Simulated microcalcifications were digitally... (More)
Purpose:

To investigate the visibility of simulated lesions in digital breast tomosynthesis (BT) image volumes compared with 2D digital mammography (DM).



Methods:

Simulated lesions (masses and microcalcifications) were added to images of the same women acquired on a DM system (Mammomat Novation, Siemens) and a BT prototype. The same beam quality was used for the DM and BT acquisitions. The total absorbed dose resulting from a 25-projection BT acquisition and reconstruction (BT(25)) was approximately twice that of a single DM view. By excluding every other projection image from the reconstruction (BT(13)), approximately the same dose as in DM was effected. Simulated microcalcifications were digitally added with varying contrast to the DM and BT images. Simulated masses with 8 mm diameter were also added to BT images. A series of 4-alternative forced choice (4AFC) human observer experiments were conducted. Four medical physicists participated in all experiments, each consisting of 60 trials per experimental condition. The observers interpreted the BT image volumes in cine-mode at a fixed image sequence speed. The required threshold contrast (S(t)) to achieve a detectability index (d') of 2.5 (i.e., 92.5% correct decisions) was determined.



Results: The S(t) for mass detection in DM was approximately a factor of 2 higher than required in BT indicating that the detection of masses was improved under BT conditions compared to DM. S(t) for microcalcification detection was higher for BT than for DM at both BT dose levels (BT(25) and BT(13)), with a statistically significant difference in S(t) between DM and BT(13). These results indicate a dose-dependent decrease in detection performance in BT for detection of microcalcifications.



Conclusions: In agreement with previous investigations, masses of size 8 mm can be detected with less contrast in BT than in DM indicating improved detection performance for BT. However, for the investigated microcalcifications, the results of this study indicate potentially worse performance for BT than for DM at the same dose level. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Medical Physics
volume
39
issue
5
pages
2431 - 2437
publisher
American Association of Physicists in Medicine
external identifiers
  • wos:000303604300013
  • pmid:22559613
  • scopus:84861617381
ISSN
0094-2405
DOI
10.1118/1.3694105
language
English
LU publication?
yes
id
a04b7ffc-ae0c-4771-94b4-8d3a56c33e39 (old id 2609109)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22559613?dopt=Abstract
date added to LUP
2012-06-02 15:56:36
date last changed
2017-09-24 04:45:19
@article{a04b7ffc-ae0c-4771-94b4-8d3a56c33e39,
  abstract     = {Purpose: <br/><br>
To investigate the visibility of simulated lesions in digital breast tomosynthesis (BT) image volumes compared with 2D digital mammography (DM).<br/><br>
<br/><br>
Methods: <br/><br>
Simulated lesions (masses and microcalcifications) were added to images of the same women acquired on a DM system (Mammomat Novation, Siemens) and a BT prototype. The same beam quality was used for the DM and BT acquisitions. The total absorbed dose resulting from a 25-projection BT acquisition and reconstruction (BT(25)) was approximately twice that of a single DM view. By excluding every other projection image from the reconstruction (BT(13)), approximately the same dose as in DM was effected. Simulated microcalcifications were digitally added with varying contrast to the DM and BT images. Simulated masses with 8 mm diameter were also added to BT images. A series of 4-alternative forced choice (4AFC) human observer experiments were conducted. Four medical physicists participated in all experiments, each consisting of 60 trials per experimental condition. The observers interpreted the BT image volumes in cine-mode at a fixed image sequence speed. The required threshold contrast (S(t)) to achieve a detectability index (d') of 2.5 (i.e., 92.5% correct decisions) was determined.<br/><br>
<br/><br>
Results: The S(t) for mass detection in DM was approximately a factor of 2 higher than required in BT indicating that the detection of masses was improved under BT conditions compared to DM. S(t) for microcalcification detection was higher for BT than for DM at both BT dose levels (BT(25) and BT(13)), with a statistically significant difference in S(t) between DM and BT(13). These results indicate a dose-dependent decrease in detection performance in BT for detection of microcalcifications.<br/><br>
<br/><br>
Conclusions: In agreement with previous investigations, masses of size 8 mm can be detected with less contrast in BT than in DM indicating improved detection performance for BT. However, for the investigated microcalcifications, the results of this study indicate potentially worse performance for BT than for DM at the same dose level.},
  author       = {Timberg, Pontus and Båth, M and Andersson, Ingvar and Mattsson, Sören and Tingberg, Anders and Ruschin, Mark},
  issn         = {0094-2405},
  language     = {eng},
  number       = {5},
  pages        = {2431--2437},
  publisher    = {American Association of Physicists in Medicine},
  series       = {Medical Physics},
  title        = {Visibility of microcalcification clusters and masses in breast tomosynthesis image volumes and digital mammography: A 4AFC human observer study.},
  url          = {http://dx.doi.org/10.1118/1.3694105},
  volume       = {39},
  year         = {2012},
}