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Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia

Konradi, C; Westin, Jenny LU ; Carta, Manolo LU ; Eaton, ME; Kuter, Katarzyna LU ; Dekundy, A; Lundblad, Martin LU and Cenci Nilsson, Angela LU (2004) In Neurobiology of Disease 17(2). p.219-236
Abstract
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+-dependent signaling, and in structural and synaptic plasticity were... (More)
We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+-dependent signaling, and in structural and synaptic plasticity were upregulated. The gene expression patterns implied that the dyskinetic striatum had increased transcriptional, as well as synaptic activity, and decreased capacity for energy production. Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended of ATP levels. (C) 2004 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
calcium, striatum, microarrays, gene, 6-hydroxydopamine, Parkinson's disease, L-DOPA, dyskinesia, GABA, ATPases, ribosomes
in
Neurobiology of Disease
volume
17
issue
2
pages
219 - 236
publisher
Elsevier
external identifiers
  • pmid:15474360
  • wos:000224757500011
  • scopus:5144228175
ISSN
0969-9961
DOI
10.1016/j.nbd.2004.07.005
language
English
LU publication?
yes
id
926387a3-19fe-44a2-bda6-a845b7c8973b (old id 262322)
date added to LUP
2007-10-23 19:14:40
date last changed
2017-07-30 03:39:20
@article{926387a3-19fe-44a2-bda6-a845b7c8973b,
  abstract     = {We have examined the pattern of striatal messenger RNA expression of over 8000 genes in a rat model of levodopa (L-DOPA)-induced dyskinesia and Parkinson disease (PD). 6-Hydroxydopamine (6-OHDA)-lesioned rats were treated with L-DOPA or physiological saline for 22 days and repeatedly tested for antiakinetic response to L-DOPA and the development of abnormal involuntary movements (AIMs). In a comparison of rats that developed a dyskinetic motor response to rats that did not, we found striking differences in gene expression patterns. In rats that developed dyskinesia, GABA neurons had an increased transcriptional activity, and genes involved in Ca2+ homeostasis, in Ca2+-dependent signaling, and in structural and synaptic plasticity were upregulated. The gene expression patterns implied that the dyskinetic striatum had increased transcriptional, as well as synaptic activity, and decreased capacity for energy production. Some basic maintenance chores such as ribosome protein biosynthesis were downregulated, possibly a response to expended of ATP levels. (C) 2004 Elsevier Inc. All rights reserved.},
  author       = {Konradi, C and Westin, Jenny and Carta, Manolo and Eaton, ME and Kuter, Katarzyna and Dekundy, A and Lundblad, Martin and Cenci Nilsson, Angela},
  issn         = {0969-9961},
  keyword      = {calcium,striatum,microarrays,gene,6-hydroxydopamine,Parkinson's disease,L-DOPA,dyskinesia,GABA,ATPases,ribosomes},
  language     = {eng},
  number       = {2},
  pages        = {219--236},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Transcriptome analysis in a rat model of L-DOPA-induced dyskinesia},
  url          = {http://dx.doi.org/10.1016/j.nbd.2004.07.005},
  volume       = {17},
  year         = {2004},
}