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Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Jenab, Mazda ; Riboli, Elio ; Ferrari, Pietro ; Sabate, Joan ; Slimani, Nadia ; Norat, Teresa ; Friesen, Marlin ; Tjonneland, Anne ; Olsen, Anja and Overvad, Kim , et al. (2006) In Carcinogenesis 27(11). p.2250-2257
Abstract
Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited, particularly so for blood measures of vitamin C. The objective of this study was to determine the association of plasma and dietary vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 European countries. Using a fluorometric method, vitamin C was measured in pre-diagnostic plasma from 215 GC cases (matched controls = 416). Conditional logistic... (More)
Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited, particularly so for blood measures of vitamin C. The objective of this study was to determine the association of plasma and dietary vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 European countries. Using a fluorometric method, vitamin C was measured in pre-diagnostic plasma from 215 GC cases (matched controls = 416). Conditional logistic regression models adjusted by body mass index, total energy intake, smoking status/duration/intensity and Helicobacter pylori infection status were used to estimate relative cancer risks. No association with GC risk was observed for dietary vitamin C, whereas an inverse GC risk was observed in the highest versus lowest quartile of plasma vitamin C [odds ratio (OR) = 0.55, 95% confidence interval (CI) = 0.31-0.97, P(trend) = 0.043], which was maintained after exclusion of cases with <or=2 years follow-up (OR = 0.40, 95% CI = 0.19-0.83, P(trend) = 0.064). The inverse association was more pronounced in subjects consuming higher levels of red and processed meats, a factor that may increase endogenous N-nitroso compound production. The effect of plasma vitamin C was not different by GC anatomical subsite (cardia/non-cardia) or histological subtype (diffuse/intestinal), and there was no significant interaction of effect with H.pylori. The results of this study show, in a prospective setting, an inverse association of GC risk with high levels of plasma vitamin C and suggest an interaction with the intake of red and processed meats, whose consumption may elevate endogenous N-nitroso compound production. (Less)
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publishing date
type
Contribution to journal
publication status
published
subject
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Carcinogenesis
volume
27
issue
11
pages
2250 - 2257
publisher
Oxford University Press
external identifiers
  • pmid:16774936
  • scopus:33750438130
ISSN
0143-3334
DOI
10.1093/carcin/bgl096
language
English
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yes
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26258e67-7217-4167-a065-d2836f2d8594 (old id 1135052)
date added to LUP
2016-04-01 11:40:00
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2019-11-26 02:59:31
@article{26258e67-7217-4167-a065-d2836f2d8594,
  abstract     = {Vitamin C is an antioxidant and inhibitor of carcinogenic N-nitroso compound production in the stomach. Higher dietary vitamin C consumption is associated with decreased risk of gastric cancer (GC) in numerous case-control studies, but data from prospective studies are limited, particularly so for blood measures of vitamin C. The objective of this study was to determine the association of plasma and dietary vitamin C levels with the risk of GC in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 European countries. Using a fluorometric method, vitamin C was measured in pre-diagnostic plasma from 215 GC cases (matched controls = 416). Conditional logistic regression models adjusted by body mass index, total energy intake, smoking status/duration/intensity and Helicobacter pylori infection status were used to estimate relative cancer risks. No association with GC risk was observed for dietary vitamin C, whereas an inverse GC risk was observed in the highest versus lowest quartile of plasma vitamin C [odds ratio (OR) = 0.55, 95% confidence interval (CI) = 0.31-0.97, P(trend) = 0.043], which was maintained after exclusion of cases with &lt;or=2 years follow-up (OR = 0.40, 95% CI = 0.19-0.83, P(trend) = 0.064). The inverse association was more pronounced in subjects consuming higher levels of red and processed meats, a factor that may increase endogenous N-nitroso compound production. The effect of plasma vitamin C was not different by GC anatomical subsite (cardia/non-cardia) or histological subtype (diffuse/intestinal), and there was no significant interaction of effect with H.pylori. The results of this study show, in a prospective setting, an inverse association of GC risk with high levels of plasma vitamin C and suggest an interaction with the intake of red and processed meats, whose consumption may elevate endogenous N-nitroso compound production.},
  author       = {Jenab, Mazda and Riboli, Elio and Ferrari, Pietro and Sabate, Joan and Slimani, Nadia and Norat, Teresa and Friesen, Marlin and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Touvier, Mathilde and Boeing, Heiner and Schulz, Mandy and Linseisen, Jakob and Nagel, Gabriele and Trichopoulou, Antonia and Naska, Androniki and Oikonomou, Eleni and Krogh, Vittorio and Panico, Salvatore and Masala, Giovanna and Sacerdote, Carlotta and Tumino, Rosario and Peeters, Petra H and Numans, Mattijs E and Bueno-de-Mesquita, Hendrik B and Büchner, Frederike L and Lund, Eiliv and Pera, Guillem and Navarro Sanchez, Carmen and Sánchez, Maria-José and Arriola, Larraitz and Barricarte, Aurelio and Quirós, José Ramón and Hallmans, Göran and Stenling, Roger and Berglund, Göran and Bingham, Sheila and Khaw, Kay-Tee and Key, Timothy and Allen, Naomi and Carneiro, Fatima and Mahlke, U and Del Giudice, Guiseppe and Palli, Domenico and Kaaks, Rudolf and Gonzalez, Carlos A},
  issn         = {0143-3334},
  language     = {eng},
  number       = {11},
  pages        = {2250--2257},
  publisher    = {Oxford University Press},
  series       = {Carcinogenesis},
  title        = {Plasma and dietary vitamin C levels and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)},
  url          = {http://dx.doi.org/10.1093/carcin/bgl096},
  doi          = {10.1093/carcin/bgl096},
  volume       = {27},
  year         = {2006},
}