IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.
(2013) In Immunity 38(5). p.958-969- Abstract
- CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+)... (More)
- CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation. (Less)
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https://lup.lub.lu.se/record/3804601
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 38
- issue
- 5
- pages
- 958 - 969
- publisher
- Cell Press
- external identifiers
-
- pmid:23664832
- wos:000330942500014
- scopus:84878167904
- ISSN
- 1074-7613
- DOI
- 10.1016/j.immuni.2013.03.009
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Mucosal Immunology (013212072), Adaptive Immunity (013212070), Department of Urology, Lund (013077000), Medicine (Lund) (013230025), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 262f3dcd-39b9-4f47-8d90-09b935e05c5d (old id 3804601)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23664832?dopt=Abstract
- date added to LUP
- 2016-04-04 08:34:27
- date last changed
- 2024-01-12 05:19:03
@article{262f3dcd-39b9-4f47-8d90-09b935e05c5d, abstract = {{CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation.}}, author = {{Persson, Emma and Uronen-Hansson, Heli and Semmrich, Monika and Rivollier, Aymeric and Hägerbrand, Karin and Marsal, Jan and Gudjonsson, Sigurdur and Håkansson, Ulf and Reizis, Boris and Kotarsky, Knut and Agace, William}}, issn = {{1074-7613}}, language = {{eng}}, number = {{5}}, pages = {{958--969}}, publisher = {{Cell Press}}, series = {{Immunity}}, title = {{IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.}}, url = {{http://dx.doi.org/10.1016/j.immuni.2013.03.009}}, doi = {{10.1016/j.immuni.2013.03.009}}, volume = {{38}}, year = {{2013}}, }