Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.

Persson, Emma LU ; Uronen-Hansson, Heli LU ; Semmrich, Monika LU ; Rivollier, Aymeric LU ; Hägerbrand, Karin LU ; Marsal, Jan LU ; Gudjonsson, Sigurdur LU ; Håkansson, Ulf LU ; Reizis, Boris and Kotarsky, Knut LU , et al. (2013) In Immunity 38(5). p.958-969
Abstract
CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+)... (More)
CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
38
issue
5
pages
958 - 969
publisher
Cell Press
external identifiers
  • pmid:23664832
  • wos:000330942500014
  • scopus:84878167904
ISSN
1074-7613
DOI
10.1016/j.immuni.2013.03.009
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Mucosal Immunology (013212072), Adaptive Immunity (013212070), Department of Urology, Lund (013077000), Medicine (Lund) (013230025), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
id
262f3dcd-39b9-4f47-8d90-09b935e05c5d (old id 3804601)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23664832?dopt=Abstract
date added to LUP
2016-04-04 08:34:27
date last changed
2024-01-12 05:19:03
@article{262f3dcd-39b9-4f47-8d90-09b935e05c5d,
  abstract     = {{CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation.}},
  author       = {{Persson, Emma and Uronen-Hansson, Heli and Semmrich, Monika and Rivollier, Aymeric and Hägerbrand, Karin and Marsal, Jan and Gudjonsson, Sigurdur and Håkansson, Ulf and Reizis, Boris and Kotarsky, Knut and Agace, William}},
  issn         = {{1074-7613}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{958--969}},
  publisher    = {{Cell Press}},
  series       = {{Immunity}},
  title        = {{IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.}},
  url          = {{http://dx.doi.org/10.1016/j.immuni.2013.03.009}},
  doi          = {{10.1016/j.immuni.2013.03.009}},
  volume       = {{38}},
  year         = {{2013}},
}