IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.
(2013) In Immunity 38(5). p.958-969- Abstract
- CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+)... (More)
- CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation. (Less)
Please use this url to cite or link to this publication:
http://lup.lub.lu.se/record/3804601
- author
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunity
- volume
- 38
- issue
- 5
- pages
- 958 - 969
- publisher
- Cell Press
- external identifiers
-
- pmid:23664832
- wos:000330942500014
- scopus:84878167904
- ISSN
- 1074-7613
- DOI
- 10.1016/j.immuni.2013.03.009
- language
- English
- LU publication?
- yes
- id
- 262f3dcd-39b9-4f47-8d90-09b935e05c5d (old id 3804601)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23664832?dopt=Abstract
- date added to LUP
- 2013-06-06 16:49:53
- date last changed
- 2019-02-10 04:31:20
@article{262f3dcd-39b9-4f47-8d90-09b935e05c5d, abstract = {CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation.}, author = {Persson, Emma and Uronen-Hansson, Heli and Semmrich, Monika and Rivollier, Aymeric and Hägerbrand, Karin and Marsal, Jan and Gudjonsson, Sigurdur and Håkansson, Ulf and Reizis, Boris and Kotarsky, Knut and Agace, William}, issn = {1074-7613}, language = {eng}, number = {5}, pages = {958--969}, publisher = {Cell Press}, series = {Immunity}, title = {IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.}, url = {http://dx.doi.org/10.1016/j.immuni.2013.03.009}, volume = {38}, year = {2013}, }