Lund University Publications

LUND UNIVERSITY LIBRARIES

Advanced

IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.

Persson, Emma LU ; Uronen-Hansson, Heli LU ; Semmrich, Monika LU ; Rivollier, Aymeric LU ; Hägerbrand, Karin LU ; Marsal, Jan LU ; Gudjonsson, Sigurdur LU ; Håkansson, Ulf LU ; Reizis, Boris and Kotarsky, Knut LU , et al. (2013) In Immunity 38(5). p.958-969
Abstract
CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+)... (More)
CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunity
volume
38
issue
5
pages
958 - 969
publisher
Cell Press
external identifiers
  • pmid:23664832
  • wos:000330942500014
  • scopus:84878167904
ISSN
1074-7613
DOI
10.1016/j.immuni.2013.03.009
language
English
LU publication?
yes
id
262f3dcd-39b9-4f47-8d90-09b935e05c5d (old id 3804601)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23664832?dopt=Abstract
date added to LUP
2013-06-06 16:49:53
date last changed
2018-12-16 04:33:57
@article{262f3dcd-39b9-4f47-8d90-09b935e05c5d,
  abstract     = {CD103(+)CD11b(+) dendritic cells (DCs) represent the major migratory DC population within the small intestinal lamina propria (SI-LP), but their in vivo function remains unclear. Here we demonstrate that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4). Mice with a DC deletion in Irf4 displayed reduced numbers of intestinal interleukin 17 (IL-17)-secreting helper T 17 (Th17) cells and failed to support Th17 cell differentiation in draining mesenteric lymph nodes (MLN) following immunization. The latter was associated with a selective reduction in CD103(+)CD11b(+) MLN DCs and DC derived IL-6. Immunized Il6(-/-) mice failed to support Th17 cell differentiation in MLN in vivo and CD103(+)CD11b(+) MLN DCs supported IL-6-dependent Th17 cell differentiation in vitro. Together, our results suggest a central role for IRF4-dependent, IL-6 producing CD103(+)CD11b(+) DCs in intestinal Th17 cell differentiation.},
  author       = {Persson, Emma and Uronen-Hansson, Heli and Semmrich, Monika and Rivollier, Aymeric and Hägerbrand, Karin and Marsal, Jan and Gudjonsson, Sigurdur and Håkansson, Ulf and Reizis, Boris and Kotarsky, Knut and Agace, William},
  issn         = {1074-7613},
  language     = {eng},
  number       = {5},
  pages        = {958--969},
  publisher    = {Cell Press},
  series       = {Immunity},
  title        = {IRF4 Transcription-Factor-Dependent CD103(+)CD11b(+) Dendritic Cells Drive Mucosal T Helper 17 Cell Differentiation.},
  url          = {http://dx.doi.org/10.1016/j.immuni.2013.03.009},
  volume       = {38},
  year         = {2013},
}