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MOSkin dosimetry for an ultra-high dose-rate, very high-energy electron irradiation environment at PEER

Cayley, James ; Tan, Yaw Ren E. ; Petasecca, Marco ; Cutajar, Dean ; Breslin, Thomas LU ; Rosenfeld, Anatoly and Lerch, Michael (2024) In Frontiers in Physics 12.
Abstract

FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time quality assurance and dosimetry systems. Furthermore, very high-energy electron research currently requires the transformation of existing non-medical accelerators into radiotherapy research environments. Accurate dosimetry is crucial for any such transformation. In this article, we assess the response of the MOSkin, developed by the Center for... (More)

FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time quality assurance and dosimetry systems. Furthermore, very high-energy electron research currently requires the transformation of existing non-medical accelerators into radiotherapy research environments. Accurate dosimetry is crucial for any such transformation. In this article, we assess the response of the MOSkin, developed by the Center for Medical Radiation Physics, which is designed for on-patient, real-time skin dose measurements during radiotherapy, and whether it exhibits dose-rate independence when exposed to 100 MeV electron beams at the Pulsed Energetic Electrons for Research (PEER) end-station. PEER utilizes the electron beam from a 100 MeV linear accelerator when it is not used as the injector for the ANSTO Australian Synchrotron. With the estimated pulse dose-rates ranging from (Formula presented.) Gy/s to (Formula presented.) Gy/s and an estimated peak bunch dose-rate of (Formula presented.) Gy/s, MOSkin measurements were verified against a scintillating screen to confirm that the MOSkin responds proportionally to the charge delivered and, therefore, exhibits dose-rate independence in this irradiation environment.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dosimetry, FLASH, MOSkin, skin dose, ultra-high dose-rate, very high-energy electrons, VHEE
in
Frontiers in Physics
volume
12
article number
1401834
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85201012173
ISSN
2296-424X
DOI
10.3389/fphy.2024.1401834
language
English
LU publication?
yes
id
2632dde7-e2b9-4d52-ad5d-5d6de2d5ceab
date added to LUP
2024-11-05 15:22:22
date last changed
2025-04-04 14:22:12
@article{2632dde7-e2b9-4d52-ad5d-5d6de2d5ceab,
  abstract     = {{<p>FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time quality assurance and dosimetry systems. Furthermore, very high-energy electron research currently requires the transformation of existing non-medical accelerators into radiotherapy research environments. Accurate dosimetry is crucial for any such transformation. In this article, we assess the response of the MOSkin, developed by the Center for Medical Radiation Physics, which is designed for on-patient, real-time skin dose measurements during radiotherapy, and whether it exhibits dose-rate independence when exposed to 100 MeV electron beams at the Pulsed Energetic Electrons for Research (PEER) end-station. PEER utilizes the electron beam from a 100 MeV linear accelerator when it is not used as the injector for the ANSTO Australian Synchrotron. With the estimated pulse dose-rates ranging from (Formula presented.) Gy/s to (Formula presented.) Gy/s and an estimated peak bunch dose-rate of (Formula presented.) Gy/s, MOSkin measurements were verified against a scintillating screen to confirm that the MOSkin responds proportionally to the charge delivered and, therefore, exhibits dose-rate independence in this irradiation environment.</p>}},
  author       = {{Cayley, James and Tan, Yaw Ren E. and Petasecca, Marco and Cutajar, Dean and Breslin, Thomas and Rosenfeld, Anatoly and Lerch, Michael}},
  issn         = {{2296-424X}},
  keywords     = {{dosimetry; FLASH; MOSkin; skin dose; ultra-high dose-rate; very high-energy electrons; VHEE}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Physics}},
  title        = {{MOSkin dosimetry for an ultra-high dose-rate, very high-energy electron irradiation environment at PEER}},
  url          = {{http://dx.doi.org/10.3389/fphy.2024.1401834}},
  doi          = {{10.3389/fphy.2024.1401834}},
  volume       = {{12}},
  year         = {{2024}},
}