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Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder

Gustafsson, Anna ; Ventorp, Filip LU ; Wisén, Anita LU ; Ohlsson, Lars; Ljunggren, Lennart and Westrin, Åsa LU (2017) In Biomarker Insights 12. p.1-6
Abstract
Inflammation has been proposed to play a role in the generation of depressive symptoms. Previously, we demonstrated that patients with major depressive disorder (MDD) have increased plasma levels of the soluble form of the urokinase receptor (suPAR), a marker for low-grade inflammation. The aim of this study was to test the hypothesis that acute exercise would induce inflammatory response characterized by increased suPAR and elucidate whether patients with MDD display altered levels of suPAR in response to acute exercise. A total of 17 patients with MDD and 17 controls were subjected to an exercise challenge. Plasma suPAR (P-suPAR) was analyzed before, during, and after exercise. There was a significantly higher baseline P-suPAR in the... (More)
Inflammation has been proposed to play a role in the generation of depressive symptoms. Previously, we demonstrated that patients with major depressive disorder (MDD) have increased plasma levels of the soluble form of the urokinase receptor (suPAR), a marker for low-grade inflammation. The aim of this study was to test the hypothesis that acute exercise would induce inflammatory response characterized by increased suPAR and elucidate whether patients with MDD display altered levels of suPAR in response to acute exercise. A total of 17 patients with MDD and 17 controls were subjected to an exercise challenge. Plasma suPAR (P-suPAR) was analyzed before, during, and after exercise. There was a significantly higher baseline P-suPAR in the patients with MDD, and the dynamic changes of P-suPAR during the exercise were significantly lower in the patients with MDD, compared with the controls. This study supports the hypothesis that an activation of systemic inflammatory processes, measured as elevated P-suPAR, is involved in the pathophysiology of depression. The study concludes that P-suPAR is influenced by acute exercise, most likely due to release from activated neutrophils. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biomarker Insights
volume
12
pages
6 pages
publisher
Libertas Academica
external identifiers
  • scopus:85035105448
  • wos:000399195800001
ISSN
1177-2719
DOI
10.1177/1177271917704193
language
English
LU publication?
yes
id
263bf434-e203-4ebf-a909-ae3715b5fd0c
date added to LUP
2017-12-05 13:32:18
date last changed
2018-03-07 03:00:19
@article{263bf434-e203-4ebf-a909-ae3715b5fd0c,
  abstract     = {Inflammation has been proposed to play a role in the generation of depressive symptoms. Previously, we demonstrated that patients with major depressive disorder (MDD) have increased plasma levels of the soluble form of the urokinase receptor (suPAR), a marker for low-grade inflammation. The aim of this study was to test the hypothesis that acute exercise would induce inflammatory response characterized by increased suPAR and elucidate whether patients with MDD display altered levels of suPAR in response to acute exercise. A total of 17 patients with MDD and 17 controls were subjected to an exercise challenge. Plasma suPAR (P-suPAR) was analyzed before, during, and after exercise. There was a significantly higher baseline P-suPAR in the patients with MDD, and the dynamic changes of P-suPAR during the exercise were significantly lower in the patients with MDD, compared with the controls. This study supports the hypothesis that an activation of systemic inflammatory processes, measured as elevated P-suPAR, is involved in the pathophysiology of depression. The study concludes that P-suPAR is influenced by acute exercise, most likely due to release from activated neutrophils.},
  author       = {Gustafsson, Anna  and Ventorp, Filip and Wisén, Anita and Ohlsson, Lars and Ljunggren, Lennart and Westrin, Åsa},
  issn         = {1177-2719},
  language     = {eng},
  pages        = {1--6},
  publisher    = {Libertas Academica},
  series       = {Biomarker Insights},
  title        = {Effects of Acute Exercise on Circulating Soluble Form of the Urokinase Receptor in Patients With Major Depressive Disorder},
  url          = {http://dx.doi.org/10.1177/1177271917704193},
  volume       = {12},
  year         = {2017},
}