Epigenetic changes induced by maternal factors during fetal life : Implication for type 1 diabetes
(2021) In Genes 12(6).- Abstract
Organ-specific autoimmune diseases, such as type 1 diabetes, are believed to result from T-cell-mediated damage of the target tissue. The immune-mediated tissue injury, in turn, is known to depend on complex interactions between genetic and environmental factors. Nevertheless, the mechanisms whereby environmental factors contribute to the pathogenesis of autoimmune diseases remain elusive and represent a major untapped target to develop novel strategies for disease prevention. Given the impact of the early environment on the developing immune system, epigenetic changes induced by maternal factors during fetal life have been linked to a likelihood of developing an autoimmune disease later in life. In humans, DNA methylation is the... (More)
Organ-specific autoimmune diseases, such as type 1 diabetes, are believed to result from T-cell-mediated damage of the target tissue. The immune-mediated tissue injury, in turn, is known to depend on complex interactions between genetic and environmental factors. Nevertheless, the mechanisms whereby environmental factors contribute to the pathogenesis of autoimmune diseases remain elusive and represent a major untapped target to develop novel strategies for disease prevention. Given the impact of the early environment on the developing immune system, epigenetic changes induced by maternal factors during fetal life have been linked to a likelihood of developing an autoimmune disease later in life. In humans, DNA methylation is the epigenetic mechanism most extensively investigated. This review provides an overview of the critical role of DNA methylation changes induced by prenatal maternal conditions contributing to the increased risk of immune-mediated diseases on the offspring, with a particular focus on T1D. A deeper understanding of epigenetic alterations induced by environmental stressors during fetal life may be pivotal for developing targeted prevention strategies of type 1 diabetes by modifying the maternal environment.
(Less)
- author
- Barchetta, Ilaria LU ; Arvastsson, Jeanette LU ; Sarmiento, Luis LU and Cilio, Corrado M. LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autoimmune diseases, DNA methylation, Epigenetics, Genomic imprint-ing, Maternal factors, Type 1 diabetes
- in
- Genes
- volume
- 12
- issue
- 6
- article number
- 887
- publisher
- MDPI AG
- external identifiers
-
- scopus:85108222195
- pmid:34201206
- ISSN
- 2073-4425
- DOI
- 10.3390/genes12060887
- language
- English
- LU publication?
- yes
- id
- 26487a78-9b29-4676-b2c3-bfbeb810a0d6
- date added to LUP
- 2021-07-16 11:00:05
- date last changed
- 2024-06-15 13:34:13
@article{26487a78-9b29-4676-b2c3-bfbeb810a0d6,
abstract = {{<p>Organ-specific autoimmune diseases, such as type 1 diabetes, are believed to result from T-cell-mediated damage of the target tissue. The immune-mediated tissue injury, in turn, is known to depend on complex interactions between genetic and environmental factors. Nevertheless, the mechanisms whereby environmental factors contribute to the pathogenesis of autoimmune diseases remain elusive and represent a major untapped target to develop novel strategies for disease prevention. Given the impact of the early environment on the developing immune system, epigenetic changes induced by maternal factors during fetal life have been linked to a likelihood of developing an autoimmune disease later in life. In humans, DNA methylation is the epigenetic mechanism most extensively investigated. This review provides an overview of the critical role of DNA methylation changes induced by prenatal maternal conditions contributing to the increased risk of immune-mediated diseases on the offspring, with a particular focus on T1D. A deeper understanding of epigenetic alterations induced by environmental stressors during fetal life may be pivotal for developing targeted prevention strategies of type 1 diabetes by modifying the maternal environment.</p>}},
author = {{Barchetta, Ilaria and Arvastsson, Jeanette and Sarmiento, Luis and Cilio, Corrado M.}},
issn = {{2073-4425}},
keywords = {{Autoimmune diseases; DNA methylation; Epigenetics; Genomic imprint-ing; Maternal factors; Type 1 diabetes}},
language = {{eng}},
number = {{6}},
publisher = {{MDPI AG}},
series = {{Genes}},
title = {{Epigenetic changes induced by maternal factors during fetal life : Implication for type 1 diabetes}},
url = {{http://dx.doi.org/10.3390/genes12060887}},
doi = {{10.3390/genes12060887}},
volume = {{12}},
year = {{2021}},
}