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The Association between Serum Testosterone and Risk Factors for Atherosclerosis

Rezanezhad, Babak LU ; Borgquist, Rasmus LU ; Willenheimer, Ronnie LU and Elzanaty, Saad LU (2019) In Current Urology 13(2). p.101-106
Abstract

Objective: To study the associations between serum testosterone and risk factors for atherosclerosis in 119 men from general population. Methods: Systolic pressure, body mass index (BMI), testosterone, fasting glucose, glucose tolerance test, apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), and ApoB/ApoA-1 ratio were assessed. Subjects classified into hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal men (testosterone > 12 nmol/l). Results: BMI (28 vs. 26 kg/m2, p = 0.01), systolic pressure (129 vs. 123 mmHg, p = 0.03), fasting glucose (5.9 vs. 5.5 mmol/l, p = 0.03), ApoB (1.1 vs. 1.0 g/l, p = 0.03), and ApoB/ApoA-1 ratio (0.8 vs. 0.7, p = 0.03) were higher in hypogonadal compared to eugonadal men, respectively. In adjusted... (More)

Objective: To study the associations between serum testosterone and risk factors for atherosclerosis in 119 men from general population. Methods: Systolic pressure, body mass index (BMI), testosterone, fasting glucose, glucose tolerance test, apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), and ApoB/ApoA-1 ratio were assessed. Subjects classified into hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal men (testosterone > 12 nmol/l). Results: BMI (28 vs. 26 kg/m2, p = 0.01), systolic pressure (129 vs. 123 mmHg, p = 0.03), fasting glucose (5.9 vs. 5.5 mmol/l, p = 0.03), ApoB (1.1 vs. 1.0 g/l, p = 0.03), and ApoB/ApoA-1 ratio (0.8 vs. 0.7, p = 0.03) were higher in hypogonadal compared to eugonadal men, respectively. In adjusted multivariate regression analysis model, testosterone showed negative associations with BMI (β =-1.832, p = 0.030, 95% CI =-3.485-0.180), fasting glucose (β =-0.394, p = 0.011, 95% CI =-0.696-0.091), glucose tolerance test (β =-0.957, p = 0.045, 95% CI =-1.892-0.022), ApoB (β =-0.157, p = 0.017, 95% CI =-0.286-0.029), and ApoB/ApoA-1 ratio (β =-0.118, p = 0.046, 95% CI =-0.234-0.002). Conclusions: These results suggest an inverse association between testosterone levels and risk factors for atherosclerosis.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apolipoprotein B, Atherosclerosis, Hyperlipidemia, Hypogonadism
in
Current Urology
volume
13
issue
2
pages
6 pages
publisher
S. Karger AG
external identifiers
  • scopus:85073150182
ISSN
1661-7649
DOI
10.1159/000499285
language
English
LU publication?
yes
id
2658d4e8-6c4f-4b6f-b0f7-eac71b17b288
date added to LUP
2019-10-22 11:02:38
date last changed
2019-10-22 11:02:38
@article{2658d4e8-6c4f-4b6f-b0f7-eac71b17b288,
  abstract     = {<p>Objective: To study the associations between serum testosterone and risk factors for atherosclerosis in 119 men from general population. Methods: Systolic pressure, body mass index (BMI), testosterone, fasting glucose, glucose tolerance test, apolipoprotein A-1 (ApoA-1), apolipoprotein B (ApoB), and ApoB/ApoA-1 ratio were assessed. Subjects classified into hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal men (testosterone &gt; 12 nmol/l). Results: BMI (28 vs. 26 kg/m2, p = 0.01), systolic pressure (129 vs. 123 mmHg, p = 0.03), fasting glucose (5.9 vs. 5.5 mmol/l, p = 0.03), ApoB (1.1 vs. 1.0 g/l, p = 0.03), and ApoB/ApoA-1 ratio (0.8 vs. 0.7, p = 0.03) were higher in hypogonadal compared to eugonadal men, respectively. In adjusted multivariate regression analysis model, testosterone showed negative associations with BMI (β =-1.832, p = 0.030, 95% CI =-3.485-0.180), fasting glucose (β =-0.394, p = 0.011, 95% CI =-0.696-0.091), glucose tolerance test (β =-0.957, p = 0.045, 95% CI =-1.892-0.022), ApoB (β =-0.157, p = 0.017, 95% CI =-0.286-0.029), and ApoB/ApoA-1 ratio (β =-0.118, p = 0.046, 95% CI =-0.234-0.002). Conclusions: These results suggest an inverse association between testosterone levels and risk factors for atherosclerosis.</p>},
  author       = {Rezanezhad, Babak and Borgquist, Rasmus and Willenheimer, Ronnie and Elzanaty, Saad},
  issn         = {1661-7649},
  keyword      = {Apolipoprotein B,Atherosclerosis,Hyperlipidemia,Hypogonadism},
  language     = {eng},
  number       = {2},
  pages        = {101--106},
  publisher    = {S. Karger AG},
  series       = {Current Urology},
  title        = {The Association between Serum Testosterone and Risk Factors for Atherosclerosis},
  url          = {http://dx.doi.org/10.1159/000499285},
  volume       = {13},
  year         = {2019},
}