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K-ATP-channels and glucagon secretion glucose-regulated

Rorsman, Patrik LU ; Salehi, S Albert LU orcid ; Abdulkader, Fernando ; Braun, Matthias and MacDonald, Patrick E. (2008) In Trends in Endocrinology and Metabolism 19(8). p.277-284
Abstract
Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Endocrinology and Metabolism
volume
19
issue
8
pages
277 - 284
publisher
Elsevier
external identifiers
  • wos:000260444900002
  • scopus:52049105359
ISSN
1879-3061
DOI
10.1016/j.tem.2008.07.003
language
English
LU publication?
yes
id
2714f5a6-ddcf-48c2-9179-0d323ef5d330 (old id 1283754)
date added to LUP
2016-04-01 12:37:39
date last changed
2025-10-14 11:37:28
@article{2714f5a6-ddcf-48c2-9179-0d323ef5d330,
  abstract     = {{Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.}},
  author       = {{Rorsman, Patrik and Salehi, S Albert and Abdulkader, Fernando and Braun, Matthias and MacDonald, Patrick E.}},
  issn         = {{1879-3061}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{277--284}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Endocrinology and Metabolism}},
  title        = {{K-ATP-channels and glucagon secretion glucose-regulated}},
  url          = {{http://dx.doi.org/10.1016/j.tem.2008.07.003}},
  doi          = {{10.1016/j.tem.2008.07.003}},
  volume       = {{19}},
  year         = {{2008}},
}