Urinary bladder contraction and relaxation: Physiology and pathophysiology
Andersson, Karl-Erik LU
and Arner, Anders
LU
(2004)
In Physiological Reviews
84(3).
p.935-986
- Abstract
- The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling,... (More)
- The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors. Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/273347
- author
- Andersson, Karl-Erik
LU
and Arner, Anders
LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physiological Reviews
- volume
- 84
- issue
- 3
- pages
- 935 - 986
- publisher
- American Physiological Society
- external identifiers
-
- wos:000222357500008
- pmid:15269341
- scopus:3042637079
- ISSN
- 1522-1210
- DOI
- 10.1152/physrev.00038.2003
- language
- English
- LU publication?
- yes
- id
- d2fd62f2-c600-4c44-b419-dfba16cf8fdd (old id 273347)
- date added to LUP
- 2016-04-01 11:57:55
- date last changed
- 2022-04-21 00:20:05
@article{d2fd62f2-c600-4c44-b419-dfba16cf8fdd,
abstract = {{The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors. Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested.}},
author = {{Andersson, Karl-Erik and Arner, Anders}},
issn = {{1522-1210}},
language = {{eng}},
number = {{3}},
pages = {{935--986}},
publisher = {{American Physiological Society}},
series = {{Physiological Reviews}},
title = {{Urinary bladder contraction and relaxation: Physiology and pathophysiology}},
url = {{http://dx.doi.org/10.1152/physrev.00038.2003}},
doi = {{10.1152/physrev.00038.2003}},
volume = {{84}},
year = {{2004}},
}