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Urinary bladder contraction and relaxation: Physiology and pathophysiology

Andersson, Karl-Erik LU and Arner, Anders LU (2004) In Physiological Reviews 84(3). p.935-986
Abstract
The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling,... (More)
The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors. Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Physiological Reviews
volume
84
issue
3
pages
935 - 986
publisher
American Physiological Society
external identifiers
  • wos:000222357500008
  • pmid:15269341
  • scopus:3042637079
ISSN
1522-1210
DOI
10.1152/physrev.00038.2003
language
English
LU publication?
yes
id
d2fd62f2-c600-4c44-b419-dfba16cf8fdd (old id 273347)
date added to LUP
2007-10-16 13:05:32
date last changed
2017-12-10 03:45:21
@article{d2fd62f2-c600-4c44-b419-dfba16cf8fdd,
  abstract     = {The detrusor smooth muscle is the main muscle component of the urinary bladder wall. Its ability to contract over a large length interval and to relax determines the bladder function during filling and micturition. These processes are regulated by several external nervous and hormonal control systems, and the detrusor contains multiple receptors and signaling pathways. Functional changes of the detrusor can be found in several clinically important conditions, e.g., lower urinary tract symptoms (LUTS) and bladder outlet obstruction. The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors. Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested.},
  author       = {Andersson, Karl-Erik and Arner, Anders},
  issn         = {1522-1210},
  language     = {eng},
  number       = {3},
  pages        = {935--986},
  publisher    = {American Physiological Society},
  series       = {Physiological Reviews},
  title        = {Urinary bladder contraction and relaxation: Physiology and pathophysiology},
  url          = {http://dx.doi.org/10.1152/physrev.00038.2003},
  volume       = {84},
  year         = {2004},
}