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An altered immune response to Epstein-Barr virus in multiple sclerosis - A prospective study

Sundstrom, P; Juto, P; Wadell, G; Hallmans, G; Svenningsson, A; Nystrom, L; Dillner, Joakim LU and Forsgren, L (2004) In Neurology 62(12). p.2277-2282
Abstract
Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy... (More)
Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurology
volume
62
issue
12
pages
2277 - 2282
publisher
American Academy of Neurology
external identifiers
  • wos:000222178600023
  • pmid:15210894
  • scopus:2942752168
ISSN
1526-632X
language
English
LU publication?
yes
id
78b9cd75-fd1d-4664-933f-c7cab6879d5b (old id 273747)
alternative location
http://www.neurology.org/cgi/content/abstract/62/12/2277
date added to LUP
2007-11-02 10:40:43
date last changed
2017-11-05 04:24:39
@article{78b9cd75-fd1d-4664-933f-c7cab6879d5b,
  abstract     = {Objective: To investigate the association between human herpesviruses and multiple sclerosis ( MS), as well as between measles virus and MS. Methods: The authors identified prospectively collected serum samples from 73 MS cases and retrospective sera from 161 MS cases in two population-based serum bank registers. Analyses of IgG antibody responses in cases and matched referents were performed for Epstein-Barr virus (EBV [EBNA-1 and VCA]), human herpesvirus 6 (HHV-6), herpes simplex virus (HSV), varicella zoster virus (VZV), and measles. Results: All cases showed signs of past EBV infection. High activity to EBNA-1 and HHV-6 significantly ( borderline significance for HHV-6) increased the risk for MS in prospective sera. A discrepancy between activities to EBNA-1 and VCA was striking in MS samples collected less than 5 years before relapsing-remitting MS onset, where high activity to EBNA-1 significantly increased, and high VCA activity significantly decreased the risk for MS. There was no support for major causal roles for HSV, VZV, or measles. Conclusion: Individuals who will develop MS exhibit an altered immune response against the EBV virus characterized by a high IgG activity to EBNA-1 in the absence of high activity to VCA, this being most pronounced in the 5-year period preceding MS onset.},
  author       = {Sundstrom, P and Juto, P and Wadell, G and Hallmans, G and Svenningsson, A and Nystrom, L and Dillner, Joakim and Forsgren, L},
  issn         = {1526-632X},
  language     = {eng},
  number       = {12},
  pages        = {2277--2282},
  publisher    = {American Academy of Neurology},
  series       = {Neurology},
  title        = {An altered immune response to Epstein-Barr virus in multiple sclerosis - A prospective study},
  volume       = {62},
  year         = {2004},
}