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Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males

Sandqvist, M ; Nyberg, G ; Hammarstedt, A ; Klintland, N ; Gogg, S ; Caidahl, K ; Ahrén, Bo LU ; Smith, U and Jansson, PA (2005) In Atherosclerosis 180(1). p.119-125
Abstract
Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal... (More)
Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal rate during the clamp (8.7 +/- 0.8 mg/kg LBM/min versus 10.3 +/- 1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129 +/- 4% versus 116 +/- 2%; p < 0.02) and Tr was decreased (150 +/- 3 ms versus 171 +/- 5 ms; P < 0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. Conclusions: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness. (Less)
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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tissue, endothelium, insulin resistance, arterial stiffness, adipose, IRS-1
in
Atherosclerosis
volume
180
issue
1
pages
119 - 125
publisher
Elsevier
external identifiers
  • wos:000228812700016
  • pmid:15823284
  • scopus:17044381272
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2004.11.006
language
English
LU publication?
yes
id
275b0661-6744-4eaf-af70-ab5e3bf28b85 (old id 243803)
date added to LUP
2016-04-01 11:51:28
date last changed
2025-04-04 15:18:17
@article{275b0661-6744-4eaf-af70-ab5e3bf28b85,
  abstract     = {{Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal rate during the clamp (8.7 +/- 0.8 mg/kg LBM/min versus 10.3 +/- 1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129 +/- 4% versus 116 +/- 2%; p &lt; 0.02) and Tr was decreased (150 +/- 3 ms versus 171 +/- 5 ms; P &lt; 0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. Conclusions: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness.}},
  author       = {{Sandqvist, M and Nyberg, G and Hammarstedt, A and Klintland, N and Gogg, S and Caidahl, K and Ahrén, Bo and Smith, U and Jansson, PA}},
  issn         = {{1879-1484}},
  keywords     = {{tissue; endothelium; insulin resistance; arterial stiffness; adipose; IRS-1}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{119--125}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2004.11.006}},
  doi          = {{10.1016/j.atherosclerosis.2004.11.006}},
  volume       = {{180}},
  year         = {{2005}},
}