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Joint effects of different human papillomaviruses and Chlamydia trachomatis infections on risk of squamous cell carcinoma of the cervix uteri

Luostarinen, T; Lehtinen, M; Bjorge, T; Abeler, V; Hakama, M; Hallmans, G; Jellum, E; Koskela, P; Lenner, P and Lie, AK, et al. (2004) In European Journal of Cancer 40(7). p.1058-1065
Abstract
This case-control study based in Nordic serum banks evaluated the joint effects of infections with genital human papillomavirus (HPV) types, and Chlamydia trachomatis in the aetiology of cervical squamous cell carcinoma. Through a linkage with the cancer registries, 144 cases were identified and 420 controls matched to them. Exposure to past infections was defined by the presence of specific IgG antibodies. The odds ratio (OR) for the second-order interaction of HPV16, HPV6/11 and C. trachomatis was small (1.0) compared to the expected multiplicative OR, 57, and the additive OR, 11. The interactions were not materially different among HPV16 DNA-positive squamous cell carcinomas. When HPV16 was replaced with HPV18/33 in the analysis of... (More)
This case-control study based in Nordic serum banks evaluated the joint effects of infections with genital human papillomavirus (HPV) types, and Chlamydia trachomatis in the aetiology of cervical squamous cell carcinoma. Through a linkage with the cancer registries, 144 cases were identified and 420 controls matched to them. Exposure to past infections was defined by the presence of specific IgG antibodies. The odds ratio (OR) for the second-order interaction of HPV16, HPV6/11 and C. trachomatis was small (1.0) compared to the expected multiplicative OR, 57, and the additive OR, 11. The interactions were not materially different among HPV16 DNA-positive squamous cell carcinomas. When HPV16 was replaced with HPV18/33 in the analysis of second-order interactions with HPV6/11 and C. trachomatis, there was no evidence of interaction, the joint effect being close to the expected additive OR. Possible explanations for the observed antagonism include misclassification, selection bias or a true biological phenomenon with HPV6/11 and C. trachomatis exposures antagonizing the carcinogenic effects of HPV16. (C) 2004 Elsevier Ltd. All rights reserved. (Less)
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publication status
published
subject
keywords
papillomaviruses, neoplasms, cervix, interaction, Chlamydia trachomatis
in
European Journal of Cancer
volume
40
issue
7
pages
1058 - 1065
publisher
IFAC & Elsevier Ltd.
external identifiers
  • pmid:15093583
  • wos:000221467400027
  • scopus:11144357251
ISSN
1879-0852
DOI
10.1016/j.ejca.2003.11.032
language
English
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yes
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e44411a9-9b3a-4355-bdb1-df6e83175a66 (old id 279055)
date added to LUP
2007-10-24 21:27:26
date last changed
2017-01-01 05:07:37
@article{e44411a9-9b3a-4355-bdb1-df6e83175a66,
  abstract     = {This case-control study based in Nordic serum banks evaluated the joint effects of infections with genital human papillomavirus (HPV) types, and Chlamydia trachomatis in the aetiology of cervical squamous cell carcinoma. Through a linkage with the cancer registries, 144 cases were identified and 420 controls matched to them. Exposure to past infections was defined by the presence of specific IgG antibodies. The odds ratio (OR) for the second-order interaction of HPV16, HPV6/11 and C. trachomatis was small (1.0) compared to the expected multiplicative OR, 57, and the additive OR, 11. The interactions were not materially different among HPV16 DNA-positive squamous cell carcinomas. When HPV16 was replaced with HPV18/33 in the analysis of second-order interactions with HPV6/11 and C. trachomatis, there was no evidence of interaction, the joint effect being close to the expected additive OR. Possible explanations for the observed antagonism include misclassification, selection bias or a true biological phenomenon with HPV6/11 and C. trachomatis exposures antagonizing the carcinogenic effects of HPV16. (C) 2004 Elsevier Ltd. All rights reserved.},
  author       = {Luostarinen, T and Lehtinen, M and Bjorge, T and Abeler, V and Hakama, M and Hallmans, G and Jellum, E and Koskela, P and Lenner, P and Lie, AK and Paavonen, J and Pukkala, E and Saikku, P and Sigstad, E and Thoresen, S and Youngman, LD and Dillner, Joakim and Hakulinen, T},
  issn         = {1879-0852},
  keyword      = {papillomaviruses,neoplasms,cervix,interaction,Chlamydia trachomatis},
  language     = {eng},
  number       = {7},
  pages        = {1058--1065},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Joint effects of different human papillomaviruses and Chlamydia trachomatis infections on risk of squamous cell carcinoma of the cervix uteri},
  url          = {http://dx.doi.org/10.1016/j.ejca.2003.11.032},
  volume       = {40},
  year         = {2004},
}