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Morbidity and mortality in gynecological cancers among first- and second-generation immigrants in Sweden

Mousavi, Seyed Mohsen; Sundquist, Kristina LU and Hemminki, Kari LU (2012) In International Journal of Cancer 131(2). p.497-504
Abstract
We studied the effect of new environment on the risk in and mortality of gynecological cancers in first- and second-generation immigrants in Sweden. We used the nationwide Swedish Family-Cancer Database to calculate standardized incidence/mortality ratios (SIRs/SMRs) of cervical, endometrial and ovarian cancers among immigrants in comparison to the native Swedes. Risk of cervical cancer increased among first-generation immigrants with Danish (SIR = 1.64), Norwegian (1.33), former Yugoslavian (1.21) and East European (1.35) origins, whereas this risk decreased among Finns (0.88) and Asians (SIRs varies from 0.11 in Iranians to 0.54 in East Asians). Risk of endometrial (SIRs varies from 0.28 in Africans to 0.86 in Finns) and ovarian (SIRs... (More)
We studied the effect of new environment on the risk in and mortality of gynecological cancers in first- and second-generation immigrants in Sweden. We used the nationwide Swedish Family-Cancer Database to calculate standardized incidence/mortality ratios (SIRs/SMRs) of cervical, endometrial and ovarian cancers among immigrants in comparison to the native Swedes. Risk of cervical cancer increased among first-generation immigrants with Danish (SIR = 1.64), Norwegian (1.33), former Yugoslavian (1.21) and East European (1.35) origins, whereas this risk decreased among Finns (0.88) and Asians (SIRs varies from 0.11 in Iranians to 0.54 in East Asians). Risk of endometrial (SIRs varies from 0.28 in Africans to 0.86 in Finns) and ovarian (SIRs varies from 0.23 in Chileans to 0.82 in Finns) cancers decreased in first-generation immigrants. The overall gynecological cancer risk for the second-generation immigrants, independent of the birth region, was almost similar to that obtained for the first generations. The birth region-specific SMRs of gynecological cancers in first- and second-generation immigrants co-varied with the SIRs. Risk of gynecological cancers among the first-generation immigrants is similar to that in their original countries, except for cervical cancer among Africans and endometrial cancer among North Americans and East Europeans. Our findings show that risk and mortality of gynecological cancers observed in the first-generation immigrants remain in the second generation. We conclude that the risk and protective factors of gynecological cancers are preserved upon immigration and through generations, suggesting a role for behavioral factors or familial aggregation in the etiology of these diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cancer, cervix, endometrial, immigrants, mortality, ovary, risk, Sweden
in
International Journal of Cancer
volume
131
issue
2
pages
497 - 504
publisher
John Wiley & Sons
external identifiers
  • wos:000304350600042
  • scopus:84861597893
ISSN
0020-7136
DOI
10.1002/ijc.26395
language
English
LU publication?
yes
id
2b7aae6f-20da-403e-a4e2-6ca6587d9927 (old id 2799561)
date added to LUP
2012-07-03 10:24:15
date last changed
2017-06-18 03:00:38
@article{2b7aae6f-20da-403e-a4e2-6ca6587d9927,
  abstract     = {We studied the effect of new environment on the risk in and mortality of gynecological cancers in first- and second-generation immigrants in Sweden. We used the nationwide Swedish Family-Cancer Database to calculate standardized incidence/mortality ratios (SIRs/SMRs) of cervical, endometrial and ovarian cancers among immigrants in comparison to the native Swedes. Risk of cervical cancer increased among first-generation immigrants with Danish (SIR = 1.64), Norwegian (1.33), former Yugoslavian (1.21) and East European (1.35) origins, whereas this risk decreased among Finns (0.88) and Asians (SIRs varies from 0.11 in Iranians to 0.54 in East Asians). Risk of endometrial (SIRs varies from 0.28 in Africans to 0.86 in Finns) and ovarian (SIRs varies from 0.23 in Chileans to 0.82 in Finns) cancers decreased in first-generation immigrants. The overall gynecological cancer risk for the second-generation immigrants, independent of the birth region, was almost similar to that obtained for the first generations. The birth region-specific SMRs of gynecological cancers in first- and second-generation immigrants co-varied with the SIRs. Risk of gynecological cancers among the first-generation immigrants is similar to that in their original countries, except for cervical cancer among Africans and endometrial cancer among North Americans and East Europeans. Our findings show that risk and mortality of gynecological cancers observed in the first-generation immigrants remain in the second generation. We conclude that the risk and protective factors of gynecological cancers are preserved upon immigration and through generations, suggesting a role for behavioral factors or familial aggregation in the etiology of these diseases.},
  author       = {Mousavi, Seyed Mohsen and Sundquist, Kristina and Hemminki, Kari},
  issn         = {0020-7136},
  keyword      = {cancer,cervix,endometrial,immigrants,mortality,ovary,risk,Sweden},
  language     = {eng},
  number       = {2},
  pages        = {497--504},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Morbidity and mortality in gynecological cancers among first- and second-generation immigrants in Sweden},
  url          = {http://dx.doi.org/10.1002/ijc.26395},
  volume       = {131},
  year         = {2012},
}