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High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden

Johansson, Helena; Oden, Anders; Lerner, Ulf H.; Jutberger, Hans; Lorentzon, Mattias; Barrett-Connor, Elizabeth; Karlsson, Magnus LU ; Ljunggren, Osten; Smith, Ulf and McCloskey, Eugene, et al. (2012) In Journal of Bone and Mineral Research 27(6). p.1390-1396
Abstract
Adipocytes and osteoblasts share a common progenitor, and there is, therefore, potential for both autocrine and endocrine effects of adiponectin on skeletal metabolism. The aim of the present study was to determine whether high serum adiponectin was associated with an increased risk of fracture in elderly men. We studied the relationship between serum adiponectin and the risk of fracture in 999 elderly men drawn from the general population and recruited to the Osteoporotic Fractures in Men (MrOS) study in Gothenburg, Sweden. Baseline data included general health questionnaires, lifestyle questionnaires, body mass index (BMI), bone mineral density (BMD), serum adiponectin, osteocalcin, and leptin. Men were followed for up to 7.4 years... (More)
Adipocytes and osteoblasts share a common progenitor, and there is, therefore, potential for both autocrine and endocrine effects of adiponectin on skeletal metabolism. The aim of the present study was to determine whether high serum adiponectin was associated with an increased risk of fracture in elderly men. We studied the relationship between serum adiponectin and the risk of fracture in 999 elderly men drawn from the general population and recruited to the Osteoporotic Fractures in Men (MrOS) study in Gothenburg, Sweden. Baseline data included general health questionnaires, lifestyle questionnaires, body mass index (BMI), bone mineral density (BMD), serum adiponectin, osteocalcin, and leptin. Men were followed for up to 7.4 years (average, 5.2 years). Poisson regression was used to investigate the relationship between serum adiponectin, other risk variables and the time-to-event hazard function of fracture. Median levels of serum adiponectin at baseline were 10.4 mu g/mL (interquartile range, 7.714.3). During follow-up, 150 men sustained one or more fractures. The risk of fracture increased in parallel with increasing serum adiponectin (hazard ratio [HR]/SD, 1.46; 95% confidence interval [CI], 1.231.72) and persisted after multivariate-adjusted analysis (HR/SD, 1.30; 95% CI, 1.091.55). Serum adiponectin shows graded stepwise association with a significant excess risk of fracture in elderly men that was independent of several other risk factors for fracture. Its measurement holds promise as a risk factor for fracture in men. (C) 2012 American Society for Bone and Mineral Research. (Less)
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keywords
ADIPONECTIN, ELDERLY MEN, SPLINE POISSON REGRESSION MODEL, INCIDENT, FRACTURES
in
Journal of Bone and Mineral Research
volume
27
issue
6
pages
1390 - 1396
publisher
AMBMR
external identifiers
  • wos:000304141500016
  • scopus:84861319793
ISSN
1523-4681
DOI
10.1002/jbmr.1591
language
English
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yes
id
0873a846-cb34-4a8c-8760-9d9b4f457b2f (old id 2799713)
date added to LUP
2012-07-03 10:25:13
date last changed
2017-09-17 03:34:26
@article{0873a846-cb34-4a8c-8760-9d9b4f457b2f,
  abstract     = {Adipocytes and osteoblasts share a common progenitor, and there is, therefore, potential for both autocrine and endocrine effects of adiponectin on skeletal metabolism. The aim of the present study was to determine whether high serum adiponectin was associated with an increased risk of fracture in elderly men. We studied the relationship between serum adiponectin and the risk of fracture in 999 elderly men drawn from the general population and recruited to the Osteoporotic Fractures in Men (MrOS) study in Gothenburg, Sweden. Baseline data included general health questionnaires, lifestyle questionnaires, body mass index (BMI), bone mineral density (BMD), serum adiponectin, osteocalcin, and leptin. Men were followed for up to 7.4 years (average, 5.2 years). Poisson regression was used to investigate the relationship between serum adiponectin, other risk variables and the time-to-event hazard function of fracture. Median levels of serum adiponectin at baseline were 10.4 mu g/mL (interquartile range, 7.714.3). During follow-up, 150 men sustained one or more fractures. The risk of fracture increased in parallel with increasing serum adiponectin (hazard ratio [HR]/SD, 1.46; 95% confidence interval [CI], 1.231.72) and persisted after multivariate-adjusted analysis (HR/SD, 1.30; 95% CI, 1.091.55). Serum adiponectin shows graded stepwise association with a significant excess risk of fracture in elderly men that was independent of several other risk factors for fracture. Its measurement holds promise as a risk factor for fracture in men. (C) 2012 American Society for Bone and Mineral Research.},
  author       = {Johansson, Helena and Oden, Anders and Lerner, Ulf H. and Jutberger, Hans and Lorentzon, Mattias and Barrett-Connor, Elizabeth and Karlsson, Magnus and Ljunggren, Osten and Smith, Ulf and McCloskey, Eugene and Kanis, John A. and Ohlsson, Claes and Mellstrom, Dan},
  issn         = {1523-4681},
  keyword      = {ADIPONECTIN,ELDERLY MEN,SPLINE POISSON REGRESSION MODEL,INCIDENT,FRACTURES},
  language     = {eng},
  number       = {6},
  pages        = {1390--1396},
  publisher    = {AMBMR},
  series       = {Journal of Bone and Mineral Research},
  title        = {High serum adiponectin predicts incident fractures in elderly men: Osteoporotic fractures in men (MrOS) Sweden},
  url          = {http://dx.doi.org/10.1002/jbmr.1591},
  volume       = {27},
  year         = {2012},
}