Ornithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids.
(2007) In Biochemical Society Transactions 35(Pt 2). p.314-317- Abstract
- The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine... (More)
- The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine decarboxylase). In the present paper, some of the available information on ODC and AdoMetDC in trypanosomatids will be described and discussed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/166367
- author
- Persson, Lo LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- drug target, decarboxylase, ornithine decarboxylase (ODC), polyamine, protozoan parasite, S-adenosylmethionine
- in
- Biochemical Society Transactions
- volume
- 35
- issue
- Pt 2
- pages
- 314 - 317
- publisher
- Biochemical Society
- external identifiers
-
- wos:000245705800040
- scopus:34247139206
- ISSN
- 0300-5127
- language
- English
- LU publication?
- yes
- id
- 27e24d7d-f28a-46fd-91f1-b973bfb4cc2a (old id 166367)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17371268&dopt=Abstract
- date added to LUP
- 2016-04-01 12:10:33
- date last changed
- 2022-01-26 23:53:04
@article{27e24d7d-f28a-46fd-91f1-b973bfb4cc2a,
abstract = {{The production of polyamines has been shown to be an effective target for a drug against the West African form of sleeping sickness caused by Trypanosoma brucei gambiense. T. brucei belongs to the group of protozoan parasites classed as trypanosomatids. Parasitic species of this group are the causative agents of various tropical diseases besides African sleeping sickness, e.g. Chagas' disease (Trypanosoma cruzi), cutaneous (lesihmania spp.) and visceral ((eishmania donovani) leishmaniasis. The metabolism of polyamines in the parasites is a potential target for the development of new drugs for treatment of these diseases. The key steps in polyamine synthesis are catalysed by ODC (ornithine decarboxylase) and AdoMetDC (S-adenosylmethionine decarboxylase). In the present paper, some of the available information on ODC and AdoMetDC in trypanosomatids will be described and discussed.}},
author = {{Persson, Lo}},
issn = {{0300-5127}},
keywords = {{drug target; decarboxylase; ornithine decarboxylase (ODC); polyamine; protozoan parasite; S-adenosylmethionine}},
language = {{eng}},
number = {{Pt 2}},
pages = {{314--317}},
publisher = {{Biochemical Society}},
series = {{Biochemical Society Transactions}},
title = {{Ornithine decarboxylase and S-adenosylmethionine decarboxylase in trypanosomatids.}},
url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17371268&dopt=Abstract}},
volume = {{35}},
year = {{2007}},
}