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Use of nonlinear upconverting nanoparticles provide increased spatial resolution in fluorescence diffuse imaging

Svenmarker, Pontus LU ; Xu, Can LU and Andersson-Engels, Stefan LU (2010) In Optics Letters 35(16). p.2789-2791
Abstract
Fluorescence diffuse imaging suffers from limited spatial resolution. In this

letter, we report a scanning imaging approach to increase the resolution of

fluorescence diffuse imaging using nonlinear fluorophores. The resolution of

a linear flurophore was compared with nonlinear upconverting nanoparticles

(NaYF4 : Yb3+ /Tm3+ ) in a tissue phantom. A resolution improvement of a

factor of 1.3 was found experimentally. Simulations suggested a maximum

resolution improvement of a factor of 1.45. Usage of nonlinear fluorophores

is a promising method for increasing the spatial resolution in fluorescence

diffuse imaging. c 2010 Optical Society of America
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Letters
volume
35
issue
16
pages
2789 - 2791
publisher
Optical Society of America
external identifiers
  • wos:000281062400041
  • scopus:77955889469
ISSN
0146-9592
DOI
10.1364/OL.35.002789
language
English
LU publication?
yes
id
27f800a3-1c18-4612-82f8-5d1bebacc508 (old id 1659154)
alternative location
http://www.opticsinfobase.org/ol/abstract.cfm?URI=ol-35-11-1740
date added to LUP
2016-04-01 14:12:18
date last changed
2025-10-14 11:12:48
@article{27f800a3-1c18-4612-82f8-5d1bebacc508,
  abstract     = {{Fluorescence diffuse imaging suffers from limited spatial resolution. In this<br/><br>
letter, we report a scanning imaging approach to increase the resolution of<br/><br>
fluorescence diffuse imaging using nonlinear fluorophores. The resolution of<br/><br>
a linear flurophore was compared with nonlinear upconverting nanoparticles<br/><br>
(NaYF4 : Yb3+ /Tm3+ ) in a tissue phantom. A resolution improvement of a<br/><br>
factor of 1.3 was found experimentally. Simulations suggested a maximum<br/><br>
resolution improvement of a factor of 1.45. Usage of nonlinear fluorophores<br/><br>
is a promising method for increasing the spatial resolution in fluorescence<br/><br>
diffuse imaging. c 2010 Optical Society of America}},
  author       = {{Svenmarker, Pontus and Xu, Can and Andersson-Engels, Stefan}},
  issn         = {{0146-9592}},
  language     = {{eng}},
  number       = {{16}},
  pages        = {{2789--2791}},
  publisher    = {{Optical Society of America}},
  series       = {{Optics Letters}},
  title        = {{Use of nonlinear upconverting nanoparticles provide increased spatial resolution in fluorescence diffuse imaging}},
  url          = {{https://lup.lub.lu.se/search/files/3842359/2370793.pdf}},
  doi          = {{10.1364/OL.35.002789}},
  volume       = {{35}},
  year         = {{2010}},
}