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Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP

Larsson, E; Harris, HE; Larsson, A; Månsson, Bengt LU ; Saxne, Tore LU and Klareskog, L (2004) In Rheumatology1999-01-01+01:00 43(4). p.428-434
Abstract
Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Methods. DA rats with established CIA were treated with corticosteroids (betamethasone, 0.1 mg/kg body weight) or placebo (saline) intraperitoneally once daily after reaching an arthritis score exceeding 1. The treatment continued throughout the study. Arthritis progression was monitored by clinical scoring of paws, serial measurements of serum COMP and fibrinogen, and histological grading of paws. Results. Corticosteroid treatment reduced clinical signs of arthritis compared with placebo... (More)
Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Methods. DA rats with established CIA were treated with corticosteroids (betamethasone, 0.1 mg/kg body weight) or placebo (saline) intraperitoneally once daily after reaching an arthritis score exceeding 1. The treatment continued throughout the study. Arthritis progression was monitored by clinical scoring of paws, serial measurements of serum COMP and fibrinogen, and histological grading of paws. Results. Corticosteroid treatment reduced clinical signs of arthritis compared with placebo (arthritis score reduced, P < 0.01 at day 25). Corticosteroid treatment also reduced fibrinogen levels compared with placebo (P < 0.01). The morphological changes in the joint were less severe in the corticosteroid-treated animals (median cartilage score 4 in the placebo group, 0 in the corticosteroid-treated group; P < 0.01). The levels of COMP remained unchanged during treatment in the corticosteroid-treated arthritic animals, whereas an increase in levels of COMP was observed in rats treated with placebo (P < 0.01). There was a correlation between serum COMP and the extent of cartilage destruction at day 25 after immunization (r=0.77, P < 0.001). Conclusions. Corticosteroids given therapeutically to arthritic rats diminish joint destruction histologically, and stable serum COMP levels reflect this effect. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
corticosteroids, fibrinogen, collagen-induced arthritis, cartilage oligomeric matrix protein (COMP)
in
Rheumatology1999-01-01+01:00
volume
43
issue
4
pages
428 - 434
publisher
Oxford University Press
external identifiers
  • pmid:15024132
  • wos:000220340200006
  • scopus:1842833389
ISSN
1462-0332
DOI
10.1093/rheumatology/keh073
language
English
LU publication?
yes
id
252595e9-bea3-486d-ba91-30dd7e6797fd (old id 280610)
date added to LUP
2007-10-24 08:20:08
date last changed
2017-07-02 04:28:03
@article{252595e9-bea3-486d-ba91-30dd7e6797fd,
  abstract     = {Objective. To examine if changes in serum cartilage oligomeric matrix protein (COMP) correlate with the development of cartilage damage, as measured by histological grading, in corticosteroid-treated animals with collagen-induced arthritis (CIA). Methods. DA rats with established CIA were treated with corticosteroids (betamethasone, 0.1 mg/kg body weight) or placebo (saline) intraperitoneally once daily after reaching an arthritis score exceeding 1. The treatment continued throughout the study. Arthritis progression was monitored by clinical scoring of paws, serial measurements of serum COMP and fibrinogen, and histological grading of paws. Results. Corticosteroid treatment reduced clinical signs of arthritis compared with placebo (arthritis score reduced, P &lt; 0.01 at day 25). Corticosteroid treatment also reduced fibrinogen levels compared with placebo (P &lt; 0.01). The morphological changes in the joint were less severe in the corticosteroid-treated animals (median cartilage score 4 in the placebo group, 0 in the corticosteroid-treated group; P &lt; 0.01). The levels of COMP remained unchanged during treatment in the corticosteroid-treated arthritic animals, whereas an increase in levels of COMP was observed in rats treated with placebo (P &lt; 0.01). There was a correlation between serum COMP and the extent of cartilage destruction at day 25 after immunization (r=0.77, P &lt; 0.001). Conclusions. Corticosteroids given therapeutically to arthritic rats diminish joint destruction histologically, and stable serum COMP levels reflect this effect.},
  author       = {Larsson, E and Harris, HE and Larsson, A and Månsson, Bengt and Saxne, Tore and Klareskog, L},
  issn         = {1462-0332},
  keyword      = {corticosteroids,fibrinogen,collagen-induced arthritis,cartilage oligomeric matrix protein (COMP)},
  language     = {eng},
  number       = {4},
  pages        = {428--434},
  publisher    = {Oxford University Press},
  series       = {Rheumatology1999-01-01+01:00},
  title        = {Corticosteroid treatment of experimental arthritis retards cartilage destruction as determined by histology and serum COMP},
  url          = {http://dx.doi.org/10.1093/rheumatology/keh073},
  volume       = {43},
  year         = {2004},
}