Advanced

Effectiveness of vitamin D supplementation in Swedish children may be negatively impacted by BMI and serum fructose

McClorry, Shannon ; Slupsky, Carolyn M. ; Lind, Torbjörn ; Karlsland Åkeson, Pia LU ; Hernell, Olle and Öhlund, Inger (2020) In Journal of Nutritional Biochemistry 75.
Abstract

In regions where sunlight exposure is limited, dietary vitamin D intake becomes important for maintaining status. However, Swedish children have been shown to have deficient or marginal status during the winter months even if the recommended dietary intake is met. Since low vitamin D status has been associated with several disease states, this study investigated the metabolic changes associated with improved vitamin D status due to supplementation. During the 3 winter months, 5–7-year-old children (n=170) in northern (Umeå, 63° N) and southern (Malmö, 55° N) Sweden were supplemented daily with 2 (placebo), 10 or 25 μg of vitamin D. BMI-for-age z-scores (BAZ), S-25(OH)D concentrations, insulin concentrations and the serum metabolome were... (More)

In regions where sunlight exposure is limited, dietary vitamin D intake becomes important for maintaining status. However, Swedish children have been shown to have deficient or marginal status during the winter months even if the recommended dietary intake is met. Since low vitamin D status has been associated with several disease states, this study investigated the metabolic changes associated with improved vitamin D status due to supplementation. During the 3 winter months, 5–7-year-old children (n=170) in northern (Umeå, 63° N) and southern (Malmö, 55° N) Sweden were supplemented daily with 2 (placebo), 10 or 25 μg of vitamin D. BMI-for-age z-scores (BAZ), S-25(OH)D concentrations, insulin concentrations and the serum metabolome were assessed at baseline and follow-up. S-25(OH)D concentrations increased significantly in both supplementation groups (P<.001). Only arginine and isopropanol concentrations exhibited significant associations with improvements in S-25(OH)D. Furthermore, the extent to which S-25(OH)D increased was correlated with a combination of baseline BAZ and the change in serum fructose concentrations from baseline to follow up (P=.012). In particular, the change in S-25(OH)D concentrations was negatively correlated (P=.030) with the change in fructose concentrations for subjects with BAZ ≥0 and consuming at least 20 μg vitamin D daily. These results suggest that although the metabolic changes associated with improved vitamin D status are small, the effectiveness of dietary supplementation may be influenced by serum fructose concentrations.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
H NMR, 25-Hydroxy-vitamin D, Children, Fructose, Metabolomics
in
Journal of Nutritional Biochemistry
volume
75
article number
108251
publisher
Elsevier
external identifiers
  • scopus:85074594654
ISSN
0955-2863
DOI
10.1016/j.jnutbio.2019.108251
language
English
LU publication?
yes
id
2811f37f-cb47-4d6f-8279-656ef162ece6
date added to LUP
2019-11-15 13:25:14
date last changed
2020-01-13 02:31:42
@article{2811f37f-cb47-4d6f-8279-656ef162ece6,
  abstract     = {<p>In regions where sunlight exposure is limited, dietary vitamin D intake becomes important for maintaining status. However, Swedish children have been shown to have deficient or marginal status during the winter months even if the recommended dietary intake is met. Since low vitamin D status has been associated with several disease states, this study investigated the metabolic changes associated with improved vitamin D status due to supplementation. During the 3 winter months, 5–7-year-old children (n=170) in northern (Umeå, 63° N) and southern (Malmö, 55° N) Sweden were supplemented daily with 2 (placebo), 10 or 25 μg of vitamin D. BMI-for-age z-scores (BAZ), S-25(OH)D concentrations, insulin concentrations and the serum metabolome were assessed at baseline and follow-up. S-25(OH)D concentrations increased significantly in both supplementation groups (P&lt;.001). Only arginine and isopropanol concentrations exhibited significant associations with improvements in S-25(OH)D. Furthermore, the extent to which S-25(OH)D increased was correlated with a combination of baseline BAZ and the change in serum fructose concentrations from baseline to follow up (P=.012). In particular, the change in S-25(OH)D concentrations was negatively correlated (P=.030) with the change in fructose concentrations for subjects with BAZ ≥0 and consuming at least 20 μg vitamin D daily. These results suggest that although the metabolic changes associated with improved vitamin D status are small, the effectiveness of dietary supplementation may be influenced by serum fructose concentrations.</p>},
  author       = {McClorry, Shannon and Slupsky, Carolyn M. and Lind, Torbjörn and Karlsland Åkeson, Pia and Hernell, Olle and Öhlund, Inger},
  issn         = {0955-2863},
  language     = {eng},
  publisher    = {Elsevier},
  series       = {Journal of Nutritional Biochemistry},
  title        = {Effectiveness of vitamin D supplementation in Swedish children may be negatively impacted by BMI and serum fructose},
  url          = {http://dx.doi.org/10.1016/j.jnutbio.2019.108251},
  doi          = {10.1016/j.jnutbio.2019.108251},
  volume       = {75},
  year         = {2020},
}