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Coalescence times and the Meselson effect in asexual eukaryotes

Ceplitis, Alf LU (2003) In Genetical Research 82(3). p.183-190
Abstract
In asexual eukaryotes, the two allelic gene copies at a locus are expected to become highly divergent as a result of the independent accumulation of mutations in the absence of segregation. If sexual reproduction was abandoned millions of generations ago, intra-individual allelic divergences can be significantly larger than in species that reproduce sexually. Owing to the disputed existence of truly ancient asexual species, this so-called 'Meselson effect' has been put forward as a means of confirming the complete loss of sexual reproduction. Very few attempts have, however, been made at quantifying the effect of sexual reproduction on the degree of divergence between gene copies in an asexual population. Here, I describe how asexual... (More)
In asexual eukaryotes, the two allelic gene copies at a locus are expected to become highly divergent as a result of the independent accumulation of mutations in the absence of segregation. If sexual reproduction was abandoned millions of generations ago, intra-individual allelic divergences can be significantly larger than in species that reproduce sexually. Owing to the disputed existence of truly ancient asexual species, this so-called 'Meselson effect' has been put forward as a means of confirming the complete loss of sexual reproduction. Very few attempts have, however, been made at quantifying the effect of sexual reproduction on the degree of divergence between gene copies in an asexual population. Here, I describe how asexual reproduction can be regarded as a special case of population subdivision. Using a slightly modified version of the standard two-deme structured coalescent, I derive the expected coalescence time for a pair of gene copies in an asexual population and show that the Meselson effect is compatible with low rates of sexual reproduction. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Genetical Research
volume
82
issue
3
pages
183 - 190
publisher
Cambridge University Press
external identifiers
  • wos:000220642000004
  • pmid:15134197
  • scopus:1842434336
ISSN
1469-5073
DOI
10.1017/S0016672303006487
language
English
LU publication?
yes
id
231ba479-e361-4edc-9870-4a1e498c717a (old id 281878)
date added to LUP
2007-08-28 08:59:05
date last changed
2018-01-07 09:42:24
@article{231ba479-e361-4edc-9870-4a1e498c717a,
  abstract     = {In asexual eukaryotes, the two allelic gene copies at a locus are expected to become highly divergent as a result of the independent accumulation of mutations in the absence of segregation. If sexual reproduction was abandoned millions of generations ago, intra-individual allelic divergences can be significantly larger than in species that reproduce sexually. Owing to the disputed existence of truly ancient asexual species, this so-called 'Meselson effect' has been put forward as a means of confirming the complete loss of sexual reproduction. Very few attempts have, however, been made at quantifying the effect of sexual reproduction on the degree of divergence between gene copies in an asexual population. Here, I describe how asexual reproduction can be regarded as a special case of population subdivision. Using a slightly modified version of the standard two-deme structured coalescent, I derive the expected coalescence time for a pair of gene copies in an asexual population and show that the Meselson effect is compatible with low rates of sexual reproduction.},
  author       = {Ceplitis, Alf},
  issn         = {1469-5073},
  language     = {eng},
  number       = {3},
  pages        = {183--190},
  publisher    = {Cambridge University Press},
  series       = {Genetical Research},
  title        = {Coalescence times and the Meselson effect in asexual eukaryotes},
  url          = {http://dx.doi.org/10.1017/S0016672303006487},
  volume       = {82},
  year         = {2003},
}