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Type 1 diabetes associated and tissue transglutaminase autoantibodies in patients without type 1 diabetes and coeliac disease with confirmed viral infections

Sarmiento, Luis; Galvan, Jose A.; Cabrera-Rode, Eduardo; Aira, Lazaro; Correa, Consuelo; Sariego, Susel; Fonseca, Magile; Cubas-Duenas, Ileana; Hung, Lai Heng and Resik, Sonia, et al. (2012) In Journal of Medical Virology 84(7). p.1049-1053
Abstract
Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, the occurrence of type 1 diabetes associated autoantibodies (GADA and IA-2A) and tissue transglutaminase autoantibodies (TGA) was determined in patients with confirmed viral infections and no signs of type 1 diabetes or coeliac disease. Serum samples from 82 Cuban patients tested positive for PCR and IgG specific to enterovirus (HEV, serotype echovirus 16, 20 samples), EpsteinBarr virus (EBV, 20 samples), cytomegalovirus (CMV, 21 samples), and hepatitis C virus (HCV, 21 samples); and sera from 164 controls negative serologically to EBV, CMV, HCV, and echovirus 16 were enrolled in the study. All subjects were... (More)
Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, the occurrence of type 1 diabetes associated autoantibodies (GADA and IA-2A) and tissue transglutaminase autoantibodies (TGA) was determined in patients with confirmed viral infections and no signs of type 1 diabetes or coeliac disease. Serum samples from 82 Cuban patients tested positive for PCR and IgG specific to enterovirus (HEV, serotype echovirus 16, 20 samples), EpsteinBarr virus (EBV, 20 samples), cytomegalovirus (CMV, 21 samples), and hepatitis C virus (HCV, 21 samples); and sera from 164 controls negative serologically to EBV, CMV, HCV, and echovirus 16 were enrolled in the study. All subjects were screened for GADA, IA-2A, and TGA. The prevalence of TGA in patients infected with HEV, EBV, CMV, or HCV was 55% (11/20), 25% (5/20), 9.5% (2/21), and 9.5% (2/21), respectively. GADA and IA-2A were found in 15% (3/20) and 25% (5/20) of patients infected with HEV. None of the patients infected by EBV, CMV, and HCV had GADA or IA-2A. All children infected with HEV who were positive for type 1 diabetes-associated autoantibodies were also TGA-positive. None of the sera from uninfected subjects were positive for GADA, IA-2A or TGA. In conclusion, TGA can develop during infection with HEV, EBV, CMV, or HCV, while the emergence of islet cell related autoantibodies is restricted to HEV infections. The findings suggest that HEV may be a shared environmental factor for the development of islet and gut-related autoimmunity. J. Med. Virol. 84: 10491053, 2012. (C) 2012 Wiley Periodicals, Inc. (Less)
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keywords
glutamic acid decarboxylase autoantibodies, tyrosine phosphatase, autoantibodies, enterovirus, cytomegalovirus, Epstein-Barr virus
in
Journal of Medical Virology
volume
84
issue
7
pages
1049 - 1053
publisher
John Wiley & Sons
external identifiers
  • wos:000303994200008
  • scopus:84860998902
ISSN
1096-9071
DOI
10.1002/jmv.23305
language
English
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yes
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89c9bb3e-e2d2-454d-9936-06079ab1f881 (old id 2826399)
date added to LUP
2012-07-03 10:26:31
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2017-11-12 03:14:02
@article{89c9bb3e-e2d2-454d-9936-06079ab1f881,
  abstract     = {Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, the occurrence of type 1 diabetes associated autoantibodies (GADA and IA-2A) and tissue transglutaminase autoantibodies (TGA) was determined in patients with confirmed viral infections and no signs of type 1 diabetes or coeliac disease. Serum samples from 82 Cuban patients tested positive for PCR and IgG specific to enterovirus (HEV, serotype echovirus 16, 20 samples), EpsteinBarr virus (EBV, 20 samples), cytomegalovirus (CMV, 21 samples), and hepatitis C virus (HCV, 21 samples); and sera from 164 controls negative serologically to EBV, CMV, HCV, and echovirus 16 were enrolled in the study. All subjects were screened for GADA, IA-2A, and TGA. The prevalence of TGA in patients infected with HEV, EBV, CMV, or HCV was 55% (11/20), 25% (5/20), 9.5% (2/21), and 9.5% (2/21), respectively. GADA and IA-2A were found in 15% (3/20) and 25% (5/20) of patients infected with HEV. None of the patients infected by EBV, CMV, and HCV had GADA or IA-2A. All children infected with HEV who were positive for type 1 diabetes-associated autoantibodies were also TGA-positive. None of the sera from uninfected subjects were positive for GADA, IA-2A or TGA. In conclusion, TGA can develop during infection with HEV, EBV, CMV, or HCV, while the emergence of islet cell related autoantibodies is restricted to HEV infections. The findings suggest that HEV may be a shared environmental factor for the development of islet and gut-related autoimmunity. J. Med. Virol. 84: 10491053, 2012. (C) 2012 Wiley Periodicals, Inc.},
  author       = {Sarmiento, Luis and Galvan, Jose A. and Cabrera-Rode, Eduardo and Aira, Lazaro and Correa, Consuelo and Sariego, Susel and Fonseca, Magile and Cubas-Duenas, Ileana and Hung, Lai Heng and Resik, Sonia and Cilio, Corrado},
  issn         = {1096-9071},
  keyword      = {glutamic acid decarboxylase autoantibodies,tyrosine phosphatase,autoantibodies,enterovirus,cytomegalovirus,Epstein-Barr virus},
  language     = {eng},
  number       = {7},
  pages        = {1049--1053},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Medical Virology},
  title        = {Type 1 diabetes associated and tissue transglutaminase autoantibodies in patients without type 1 diabetes and coeliac disease with confirmed viral infections},
  url          = {http://dx.doi.org/10.1002/jmv.23305},
  volume       = {84},
  year         = {2012},
}