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Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years

Sorensen, J. S.; Vaziri Sani, Fariba LU ; Maziarz, M.; Kristensen, K.; Ellerman, A.; Breslow, N.; Lernmark, Åke LU ; Pociot, F.; Brorsson, C. and Birkebaek, N. H. (2012) In Diabetes Research and Clinical Practice 96(2). p.204-210
Abstract
Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined. Results: For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35% higher... (More)
Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined. Results: For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35% higher than for subjects whose IA-2A levels decreased by half (OR = 1.35 (1.09, 1.67), p = 0.006); similarly for ZnT8WA (OR = 1.39 (1.09, 1.77), p = 0.008) and ZnT8QA (OR = 1.55 (1.06, 2.26) p = 0.024). Such relationship was not detected for GADA or ZnT8RA. All OR adjusted for confounders. Conclusions: Age at diagnosis with T1D was the major predictor of detectable C-peptide 3-6 years post-diagnosis. Decreases in IA-2A, and possibly ZnT8A, levels between diagnosis and post-diagnosis were associated with a reduction in RBF post-diagnosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GAD65 autoantibodies, IA-2 autoantibodies, ZnT8 autoantibodies, Residual, beta cell function, Age at diagnosis
in
Diabetes Research and Clinical Practice
volume
96
issue
2
pages
204 - 210
publisher
Elsevier
external identifiers
  • wos:000303668000026
  • scopus:84860533291
ISSN
1872-8227
DOI
10.1016/j.diabres.2011.12.013
language
English
LU publication?
yes
id
07937b81-1274-4d4b-8fab-f8c4a80bf2a2 (old id 2826588)
date added to LUP
2012-07-03 10:26:17
date last changed
2017-01-01 03:30:41
@article{07937b81-1274-4d4b-8fab-f8c4a80bf2a2,
  abstract     = {Aims: To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D. Methods: T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined. Results: For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35% higher than for subjects whose IA-2A levels decreased by half (OR = 1.35 (1.09, 1.67), p = 0.006); similarly for ZnT8WA (OR = 1.39 (1.09, 1.77), p = 0.008) and ZnT8QA (OR = 1.55 (1.06, 2.26) p = 0.024). Such relationship was not detected for GADA or ZnT8RA. All OR adjusted for confounders. Conclusions: Age at diagnosis with T1D was the major predictor of detectable C-peptide 3-6 years post-diagnosis. Decreases in IA-2A, and possibly ZnT8A, levels between diagnosis and post-diagnosis were associated with a reduction in RBF post-diagnosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Sorensen, J. S. and Vaziri Sani, Fariba and Maziarz, M. and Kristensen, K. and Ellerman, A. and Breslow, N. and Lernmark, Åke and Pociot, F. and Brorsson, C. and Birkebaek, N. H.},
  issn         = {1872-8227},
  keyword      = {GAD65 autoantibodies,IA-2 autoantibodies,ZnT8 autoantibodies,Residual,beta cell function,Age at diagnosis},
  language     = {eng},
  number       = {2},
  pages        = {204--210},
  publisher    = {Elsevier},
  series       = {Diabetes Research and Clinical Practice},
  title        = {Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years},
  url          = {http://dx.doi.org/10.1016/j.diabres.2011.12.013},
  volume       = {96},
  year         = {2012},
}