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Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction

Thogersen, AM; Soderberg, S; Jansson, JH; Dahlen, G; Boman, K; Nilsson, TK; Lindahl, B; Weinehall, L; Stenlund, H and Lundberg, V, et al. (2004) In European Journal of Cardiovascular Prevention & Rehabilitation 11(1). p.33-40
Abstract
Background The summarized importance of haemostatic and metabolic variables (insulin, lipids including lipoprotein (a) [Lp(a)] and leptin) in predicting first myocardial infarction, as well as possible interactions among these variables, have not been reported. Design A prospective case-control study nested within the Northern Sweden Health and Disease Cohort. Methods Sixty-two men diagnosed with a first myocardial infarction were sex- and age-matched with 124 controls. Conditional logistic regression was conducted including established risk factors, plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) mass concentration, von Willebrand factor, insulin, proinsulin, specific insulin, apolipoprotein... (More)
Background The summarized importance of haemostatic and metabolic variables (insulin, lipids including lipoprotein (a) [Lp(a)] and leptin) in predicting first myocardial infarction, as well as possible interactions among these variables, have not been reported. Design A prospective case-control study nested within the Northern Sweden Health and Disease Cohort. Methods Sixty-two men diagnosed with a first myocardial infarction were sex- and age-matched with 124 controls. Conditional logistic regression was conducted including established risk factors, plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) mass concentration, von Willebrand factor, insulin, proinsulin, specific insulin, apolipoprotein A-I (apo A-I), Lp(a), and leptin. Interaction analysis was also performed for tPA, apo A-I, Lp(a), leptin and proinsulin. Results Smoking, low plasma levels of apo A-I and high plasma levels of cholesterol, Lp(a), tPA, PAI-1, proinsulin and leptin were associated with myocardial infarction in univariate conditional logistic regression analysis. High tPA [odds ratio (OR), 21.3; 95% confidence interval (CI) 2.04-222] and Lp(a) (OR, 7.21; 95% CI, 1.31-39.8) and low apo A-I (OR, 0.15; 95% CI, 0.02-0.93) remained significant risk determinants in multivariate analysis with smoking habits, body mass index, hypertension, cholesterol, and diabetes included as covariates. There were non-significant synergic interactions between high Lp(a) and leptin and tPA, respectively, and between high Lp(a) and low apo A-I. Conclusion Plasma levels of tPA, Lp(a), and apo A-I are independently associated with subsequent development of a first myocardial infarction in men. (Less)
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apolipoprotein A-I, lipoprotein(a), leptin, tissue plasminogen activator, myocardial infarction, risk factors
in
European Journal of Cardiovascular Prevention & Rehabilitation
volume
11
issue
1
pages
33 - 40
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:15167204
  • wos:000220456100005
  • scopus:12144291060
ISSN
1741-8275
DOI
10.1097/01.hjr.0000116824.84388.a2
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English
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a82d85dc-a303-42fa-9f55-1c45ab4ac950 (old id 284011)
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http://www.jcardiovascularrisk.com/pt/re/ejcpr/abstract.00149831-200402000-00006.htm;jsessionid=HhRR9hvbYQNLPphQbNYBz3ZNqpSQY552jRkQpmlpm9pfnYW91dLQ!1071114923!181195629!8091!-1
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2007-10-26 09:05:55
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2017-07-23 03:48:54
@article{a82d85dc-a303-42fa-9f55-1c45ab4ac950,
  abstract     = {Background The summarized importance of haemostatic and metabolic variables (insulin, lipids including lipoprotein (a) [Lp(a)] and leptin) in predicting first myocardial infarction, as well as possible interactions among these variables, have not been reported. Design A prospective case-control study nested within the Northern Sweden Health and Disease Cohort. Methods Sixty-two men diagnosed with a first myocardial infarction were sex- and age-matched with 124 controls. Conditional logistic regression was conducted including established risk factors, plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) mass concentration, von Willebrand factor, insulin, proinsulin, specific insulin, apolipoprotein A-I (apo A-I), Lp(a), and leptin. Interaction analysis was also performed for tPA, apo A-I, Lp(a), leptin and proinsulin. Results Smoking, low plasma levels of apo A-I and high plasma levels of cholesterol, Lp(a), tPA, PAI-1, proinsulin and leptin were associated with myocardial infarction in univariate conditional logistic regression analysis. High tPA [odds ratio (OR), 21.3; 95% confidence interval (CI) 2.04-222] and Lp(a) (OR, 7.21; 95% CI, 1.31-39.8) and low apo A-I (OR, 0.15; 95% CI, 0.02-0.93) remained significant risk determinants in multivariate analysis with smoking habits, body mass index, hypertension, cholesterol, and diabetes included as covariates. There were non-significant synergic interactions between high Lp(a) and leptin and tPA, respectively, and between high Lp(a) and low apo A-I. Conclusion Plasma levels of tPA, Lp(a), and apo A-I are independently associated with subsequent development of a first myocardial infarction in men.},
  author       = {Thogersen, AM and Soderberg, S and Jansson, JH and Dahlen, G and Boman, K and Nilsson, TK and Lindahl, B and Weinehall, L and Stenlund, H and Lundberg, V and Johnson, O and Ahrén, Bo and Hallmans, G},
  issn         = {1741-8275},
  keyword      = {apolipoprotein A-I,lipoprotein(a),leptin,tissue plasminogen activator,myocardial infarction,risk factors},
  language     = {eng},
  number       = {1},
  pages        = {33--40},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cardiovascular Prevention & Rehabilitation},
  title        = {Interactions between fibrinolysis, lipoproteins and leptin related to a first myocardial infarction},
  url          = {http://dx.doi.org/10.1097/01.hjr.0000116824.84388.a2},
  volume       = {11},
  year         = {2004},
}