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Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation

Ekdahl, KN; Bengtsson, Anders LU ; Andersson, J; Elgue, G; Ronnblom, L; Sturfelt, Gunnar LU and Nilsson, B (2004) In British Journal of Haematology 125(1). p.74-78
Abstract
Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction... (More)
Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
systemic lupus erythematosus, thrombosis, activation, platelet, beta-thromboglobulin, extracellular phosphorylation
in
British Journal of Haematology
volume
125
issue
1
pages
74 - 78
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000220154300011
  • pmid:15015972
  • scopus:1842557959
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2004.04858.x
language
English
LU publication?
yes
id
6572e447-b397-457c-8252-b5fefa97a170 (old id 284962)
date added to LUP
2007-10-22 07:55:45
date last changed
2017-01-01 05:00:01
@article{6572e447-b397-457c-8252-b5fefa97a170,
  abstract     = {Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis. Platelet-induced extracellular phosphorylation of plasma proteins suggests that this is due to persistent activation of the platelets. We examined 30 SLE patients (15 with thrombotic disease), 18 non-SLE patients with deep vein thrombosis (DVT) and 50 healthy controls by analysing beta-thromboglobulin, activated factor XI-antithrombin complexes and fibrinogen-bound phosphate. All parameters were elevated in SLE patients, particularly those with thrombosis, but normal in DVT cases and healthy controls. We conclude that thrombotic disease in SLE patients is associated with a persistent systemic platelet activation that may lower the threshold for induction of thrombosis.},
  author       = {Ekdahl, KN and Bengtsson, Anders and Andersson, J and Elgue, G and Ronnblom, L and Sturfelt, Gunnar and Nilsson, B},
  issn         = {0007-1048},
  keyword      = {systemic lupus erythematosus,thrombosis,activation,platelet,beta-thromboglobulin,extracellular phosphorylation},
  language     = {eng},
  number       = {1},
  pages        = {74--78},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2004.04858.x},
  volume       = {125},
  year         = {2004},
}