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Incidence of multiple primary malignancies among patients with bone cancers in Sweden

Ji, Jianguang LU and Hemminki, Kari LU (2006) In Journal of Cancer Research and Clinical Oncology 132(8). p.529-535
Abstract

Purpose: The present study aimed at quantifying risks for second malignancies in patients with bone cancers, and risks for second bone cancers after other primary tumors. Methods: Adjusted standardized incidence ratios (SIRs) were used as a measure of risk. Results: Among 2,546 primary bone cancer patients, a total of 171-second malignancies occurred. Besides second bone cancers, other cancer sites with an increased SIR were the soft tissues and endocrine glands. The overall risk of second malignancies following Ewing's sarcoma was 5.63, followed by chordoma (1.99), osteosarcoma (1.54), and chondrosarcoma (1.51). Patients diagnosed before age 20 years showed an increased SIR of 3.11. The increased occurrence of second bone cancers was... (More)

Purpose: The present study aimed at quantifying risks for second malignancies in patients with bone cancers, and risks for second bone cancers after other primary tumors. Methods: Adjusted standardized incidence ratios (SIRs) were used as a measure of risk. Results: Among 2,546 primary bone cancer patients, a total of 171-second malignancies occurred. Besides second bone cancers, other cancer sites with an increased SIR were the soft tissues and endocrine glands. The overall risk of second malignancies following Ewing's sarcoma was 5.63, followed by chordoma (1.99), osteosarcoma (1.54), and chondrosarcoma (1.51). Patients diagnosed before age 20 years showed an increased SIR of 3.11. The increased occurrence of second bone cancers was noted after the cancer sites of upper aerodigestive tract, kidney and nervous system. Conclusions: The incidence of second primary malignancies in bone cancer patients was moderately increased. Among histological types, Ewing's sarcoma showed the highest risk of developing second cancers. Young age was also associated with an increased risk. Besides therapeutic effects, the observed excesses of a second bone or soft tissue tumor may be related to Li-Fraumeni syndrome. Increases at other sites may be related to unknown factors or spurious findings.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Bone cancer, Chondrosarcoma, Ewing's sarcoma, Osteosarcoma, Second malignancies
in
Journal of Cancer Research and Clinical Oncology
volume
132
issue
8
pages
7 pages
publisher
Springer
external identifiers
  • scopus:33745304803
ISSN
0171-5216
DOI
10.1007/s00432-006-0100-1
language
English
LU publication?
no
id
284cd968-de92-41cc-84fd-4c2fa7af4ad6
date added to LUP
2019-01-30 10:48:22
date last changed
2019-03-08 02:17:02
@article{284cd968-de92-41cc-84fd-4c2fa7af4ad6,
  abstract     = {<p>Purpose: The present study aimed at quantifying risks for second malignancies in patients with bone cancers, and risks for second bone cancers after other primary tumors. Methods: Adjusted standardized incidence ratios (SIRs) were used as a measure of risk. Results: Among 2,546 primary bone cancer patients, a total of 171-second malignancies occurred. Besides second bone cancers, other cancer sites with an increased SIR were the soft tissues and endocrine glands. The overall risk of second malignancies following Ewing's sarcoma was 5.63, followed by chordoma (1.99), osteosarcoma (1.54), and chondrosarcoma (1.51). Patients diagnosed before age 20 years showed an increased SIR of 3.11. The increased occurrence of second bone cancers was noted after the cancer sites of upper aerodigestive tract, kidney and nervous system. Conclusions: The incidence of second primary malignancies in bone cancer patients was moderately increased. Among histological types, Ewing's sarcoma showed the highest risk of developing second cancers. Young age was also associated with an increased risk. Besides therapeutic effects, the observed excesses of a second bone or soft tissue tumor may be related to Li-Fraumeni syndrome. Increases at other sites may be related to unknown factors or spurious findings.</p>},
  author       = {Ji, Jianguang and Hemminki, Kari},
  issn         = {0171-5216},
  keyword      = {Bone cancer,Chondrosarcoma,Ewing's sarcoma,Osteosarcoma,Second malignancies},
  language     = {eng},
  month        = {08},
  number       = {8},
  pages        = {529--535},
  publisher    = {Springer},
  series       = {Journal of Cancer Research and Clinical Oncology},
  title        = {Incidence of multiple primary malignancies among patients with bone cancers in Sweden},
  url          = {http://dx.doi.org/10.1007/s00432-006-0100-1},
  volume       = {132},
  year         = {2006},
}