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Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case-control study.

Brändstedt, Johan LU ; Almquist, Martin LU ; Manjer, Jonas LU and Malm, Johan LU (2012) In Cancer Causes and Control 23(8). p.1377-1385
Abstract
OBJECTIVE:

To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium.



METHODS:

Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matched for calendar time and age at inclusion. Logistic regression analysis yielded odds ratios with 95 % confidence intervals for different quartiles and deciles. All analyses were repeated stratified for age and body mass index (BMI).



RESULTS:

We found a weak trend toward increasing... (More)
OBJECTIVE:

To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium.



METHODS:

Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matched for calendar time and age at inclusion. Logistic regression analysis yielded odds ratios with 95 % confidence intervals for different quartiles and deciles. All analyses were repeated stratified for age and body mass index (BMI).



RESULTS:

We found a weak trend toward increasing prostate cancer risk with rising vitamin D levels (p-trend across quartiles, 0.048). Dividing the cohort into deciles showed a nonlinear association. Compared to decile one, the prostate cancer risk was highest in deciles seven and eight, which corresponded to vitamin D levels of 91-97 nmol/L (1.68; 1.06-2.68), and 98-106 nmol/L (1.80; 1.13-2.85). In the other deciles, there was no association between prostate cancer risk and vitamin D levels. Albumin-adjusted calcium was positively associated with an increased risk for prostate cancer among men aged 55-65 with a BMI <25 (2.07; 1.08-3.97). No association was observed between pre-diagnostic PTH and subsequent prostate cancer incidence, and the stratified analyses revealed no other convincing relationships.



CONCLUSIONS:

This study suggests a possible weak positive nonlinear association between vitamin D and the risk of prostate cancer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer Causes and Control
volume
23
issue
8
pages
1377 - 1385
publisher
Springer
external identifiers
  • wos:000306122300017
  • pmid:22706676
  • scopus:84864884130
ISSN
1573-7225
DOI
10.1007/s10552-012-9948-3
language
English
LU publication?
yes
id
a6d47f7d-9290-46c6-848a-30a8d8b19de3 (old id 2859272)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22706676?dopt=Abstract
date added to LUP
2012-07-04 17:55:36
date last changed
2017-07-02 03:01:36
@article{a6d47f7d-9290-46c6-848a-30a8d8b19de3,
  abstract     = {OBJECTIVE: <br/><br>
To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium. <br/><br>
<br/><br>
METHODS: <br/><br>
Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matched for calendar time and age at inclusion. Logistic regression analysis yielded odds ratios with 95 % confidence intervals for different quartiles and deciles. All analyses were repeated stratified for age and body mass index (BMI). <br/><br>
<br/><br>
RESULTS: <br/><br>
We found a weak trend toward increasing prostate cancer risk with rising vitamin D levels (p-trend across quartiles, 0.048). Dividing the cohort into deciles showed a nonlinear association. Compared to decile one, the prostate cancer risk was highest in deciles seven and eight, which corresponded to vitamin D levels of 91-97 nmol/L (1.68; 1.06-2.68), and 98-106 nmol/L (1.80; 1.13-2.85). In the other deciles, there was no association between prostate cancer risk and vitamin D levels. Albumin-adjusted calcium was positively associated with an increased risk for prostate cancer among men aged 55-65 with a BMI &lt;25 (2.07; 1.08-3.97). No association was observed between pre-diagnostic PTH and subsequent prostate cancer incidence, and the stratified analyses revealed no other convincing relationships. <br/><br>
<br/><br>
CONCLUSIONS: <br/><br>
This study suggests a possible weak positive nonlinear association between vitamin D and the risk of prostate cancer.},
  author       = {Brändstedt, Johan and Almquist, Martin and Manjer, Jonas and Malm, Johan},
  issn         = {1573-7225},
  language     = {eng},
  number       = {8},
  pages        = {1377--1385},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case-control study.},
  url          = {http://dx.doi.org/10.1007/s10552-012-9948-3},
  volume       = {23},
  year         = {2012},
}