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Cognitive deficits and psychopathological symptoms among children with medulloblastoma

Szentes, Annamária; Erős, Nikoletta; Kekecs, Zoltán LU ; Jakab, Zsuzsanna; Török, Szabolcs; Schuler, Dezső; Hauser, Péter and Garami, Miklós (2018) In European Journal of Cancer Care 27(6).
Abstract

Children with medulloblastoma (MB) are predisposed for negative cognitive sequela, which has been widely identified in this population. The purpose of the present study was to explore cognitive deficits and psychopathological symptoms and analyse their relation among MB survivors. The Wechsler Intelligence Scale for Children and the Mini International Neuropsychiatric Interview (MINI-KID) was administered to 34 MB survivors to measure cognitive functioning and psychopathological symptoms. The MB survivors had lower global IQ (86.41 [79.70–93.13]) compared with the control population mean. We found impaired functioning in all IQ subscales in the MB survivors group, of which processing speed (84.15 [77.71–90.58]) was the most affected.... (More)

Children with medulloblastoma (MB) are predisposed for negative cognitive sequela, which has been widely identified in this population. The purpose of the present study was to explore cognitive deficits and psychopathological symptoms and analyse their relation among MB survivors. The Wechsler Intelligence Scale for Children and the Mini International Neuropsychiatric Interview (MINI-KID) was administered to 34 MB survivors to measure cognitive functioning and psychopathological symptoms. The MB survivors had lower global IQ (86.41 [79.70–93.13]) compared with the control population mean. We found impaired functioning in all IQ subscales in the MB survivors group, of which processing speed (84.15 [77.71–90.58]) was the most affected. Higher radiation dose and high-dose chemotherapy with stem cell rescue were significantly associated factors for lowered global IQ, while age at diagnosis, sex and time period from diagnosis were not significantly associated. Compulsive disorder, generalised anxiety, separation anxiety and posttraumatic stress disorder were significantly more prevalent in the MB survivor group than a group of 46 control participants. No correlation was found between the cognitive deficits and the psychopathological symptoms. Our results identify that MB survivors suffer from cognitive and psychopathological impairments, and these could exist independently from each other.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cognitive outcomes, IQ, late effects, medulloblastoma, paediatric brain tumour, psychopathological symptoms
in
European Journal of Cancer Care
volume
27
issue
6
publisher
John Wiley & Sons
external identifiers
  • scopus:85053399005
ISSN
0961-5423
DOI
10.1111/ecc.12912
language
English
LU publication?
yes
id
285cd4cf-95b1-4aa2-a8e8-56ed6b8fd066
date added to LUP
2018-10-24 14:23:30
date last changed
2019-02-20 11:33:24
@article{285cd4cf-95b1-4aa2-a8e8-56ed6b8fd066,
  abstract     = {<p>Children with medulloblastoma (MB) are predisposed for negative cognitive sequela, which has been widely identified in this population. The purpose of the present study was to explore cognitive deficits and psychopathological symptoms and analyse their relation among MB survivors. The Wechsler Intelligence Scale for Children and the Mini International Neuropsychiatric Interview (MINI-KID) was administered to 34 MB survivors to measure cognitive functioning and psychopathological symptoms. The MB survivors had lower global IQ (86.41 [79.70–93.13]) compared with the control population mean. We found impaired functioning in all IQ subscales in the MB survivors group, of which processing speed (84.15 [77.71–90.58]) was the most affected. Higher radiation dose and high-dose chemotherapy with stem cell rescue were significantly associated factors for lowered global IQ, while age at diagnosis, sex and time period from diagnosis were not significantly associated. Compulsive disorder, generalised anxiety, separation anxiety and posttraumatic stress disorder were significantly more prevalent in the MB survivor group than a group of 46 control participants. No correlation was found between the cognitive deficits and the psychopathological symptoms. Our results identify that MB survivors suffer from cognitive and psychopathological impairments, and these could exist independently from each other.</p>},
  articleno    = {e12912},
  author       = {Szentes, Annamária and Erős, Nikoletta and Kekecs, Zoltán and Jakab, Zsuzsanna and Török, Szabolcs and Schuler, Dezső and Hauser, Péter and Garami, Miklós},
  issn         = {0961-5423},
  keyword      = {cognitive outcomes,IQ,late effects,medulloblastoma,paediatric brain tumour,psychopathological symptoms},
  language     = {eng},
  month        = {09},
  number       = {6},
  publisher    = {John Wiley & Sons},
  series       = {European Journal of Cancer Care},
  title        = {Cognitive deficits and psychopathological symptoms among children with medulloblastoma},
  url          = {http://dx.doi.org/10.1111/ecc.12912},
  volume       = {27},
  year         = {2018},
}