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Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study

Serafini, Mauro; Jakszyn, Paula; Lujan-Barroso, Leila; Agudo, Antonio; Bueno-de-Mesquita, H. Bas; van Duijnhoven, Franzel J. B.; Jenab, Mazda; Navarro, Carmen; Palli, Domenico and Boeing, Heiner, et al. (2012) In International Journal of Cancer 131(4). p.544-554
Abstract
A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC... (More)
A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.460.95) and TRAP (adjusted HR 0.61; 95%CI (0.430.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.220.76) p for trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.280.97) p for trend <0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.210.75) p < 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC. (Less)
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Contribution to journal
publication status
published
subject
keywords
longitudinal studies, antioxidant capacity, diet, stomach cancer
in
International Journal of Cancer
volume
131
issue
4
pages
544 - 554
publisher
John Wiley & Sons
external identifiers
  • wos:000305451300022
  • scopus:84862544932
ISSN
0020-7136
DOI
10.1002/ijc.27347
language
English
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yes
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2215bdb9-bc2d-4a10-90a1-3c213e14871e (old id 2863543)
date added to LUP
2012-08-01 09:43:19
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2017-10-22 03:06:40
@article{2215bdb9-bc2d-4a10-90a1-3c213e14871e,
  abstract     = {A high intake of dietary antioxidant compounds has been hypothesized to be an appropriate strategy to reduce gastric cancer (GC) development. We investigated the effect of dietary total antioxidant capacity (TAC) in relation to GC in the European Prospective Investigation into Cancer (EPIC) study including 23 centers in 10 European countries. A total of 521,457 subjects (153,447 men) aged mostly 3570 years old, were recruited largely between 1992 and 1998. Ferric reducing antioxidant potential (FRAP) and total radical-trapping antioxidant parameter (TRAP), measuring reducing and chain-breaking antioxidant capacity were used to measure dietary TAC from plant foods. Dietary antioxidant intake is associated with a reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI (0.460.95) and TRAP (adjusted HR 0.61; 95%CI (0.430.87) (highest vs. lowest quintile). The association was observed for both cardia and noncardia cancers. A clear effect was observed in smokers with a significant reduction in GC risk for the fifth quintile of intake for both assays (highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.220.76) p for trend &lt;0.001 for FRAP; adjusted HR 0.52; 95%CI (0.280.97) p for trend &lt;0.001 for TRAP) but not in nonsmokers. In former smokers, the association with FRAP intake was statistically significant (highest vs. lowest quintile: adjusted HR 0.4; 95%CI (0.210.75) p &lt; 0.05); no association was observed for TRAP. Dietary antioxidant capacity intake from different sources of plant foods is associated with a reduction in the risk of GC.},
  author       = {Serafini, Mauro and Jakszyn, Paula and Lujan-Barroso, Leila and Agudo, Antonio and Bueno-de-Mesquita, H. Bas and van Duijnhoven, Franzel J. B. and Jenab, Mazda and Navarro, Carmen and Palli, Domenico and Boeing, Heiner and Wallström, Peter and Regnér, Sara and Numans, Mattijs E. and Carneiro, Fatima and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise and Morois, Sophie and Grioni, Sara and Panico, Salvatore and Tumino, Rosario and Sacerdote, Carlotta and Ramon Quiros, Jose and Molina-Montes, Esther and Huerta Castano, Jose M. and Barricarte, Aurelio and Amiano, Pilar and Khaw, Kay-Tee and Wareham, Nicholas and Allen, Naomi E. and Key, Timothy J. and Jeurnink, Suzanne M. and Peeters, Petra H. M. and Bamia, Christina and Valanou, Elisabeth and Trichopoulou, Antonia and Kaaks, Rudolf and Lukanova, Annekatrin and Bergmann, Manuela M. and Lindkvist, Bjorn and Stenling, Roger and Johansson, Ingegerd and Dahm, Christina C. and Overvad, Kim and Jensen, Majken and Olsen, Anja and Tjonneland, Anne and Lund, Eiliv and Rinaldi, Sabina and Michaud, Dominique and Mouw, Traci and Riboli, Elio and Gonzalez, Carlos A.},
  issn         = {0020-7136},
  keyword      = {longitudinal studies,antioxidant capacity,diet,stomach cancer},
  language     = {eng},
  number       = {4},
  pages        = {544--554},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Dietary total antioxidant capacity and gastric cancer risk in the European prospective investigation into cancer and nutrition study},
  url          = {http://dx.doi.org/10.1002/ijc.27347},
  volume       = {131},
  year         = {2012},
}