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Giant Cell Arteritis versus Takayasu Arteritis: An Update

Stamatis, Pavlos LU orcid (2020) In Mediterranean Journal of Rheumatology 31(2). p.174-182
Abstract
Giant cell arteritis (GCA) and Takayasu Arteritis (TAK) are two systemic granulomatous vasculitides affecting medium- and large-sized arteries. Similarities in GCA and TAK regarding the clinical presentation, the systemic inflammatory response and the distribution of the arterial lesions, have triggered a debate over the last decade about whether GCA and TAK represent two different diseases, or are age-associated different clinical phenotypes of the same disease. On the other hand, there are differences regarding epidemiology, several clinical features (eg, polymyalgia rheumatica in GCA) and treatment. The aim of this review is to present the latest data regarding this question and to shed some light on the differences and similarities... (More)
Giant cell arteritis (GCA) and Takayasu Arteritis (TAK) are two systemic granulomatous vasculitides affecting medium- and large-sized arteries. Similarities in GCA and TAK regarding the clinical presentation, the systemic inflammatory response and the distribution of the arterial lesions, have triggered a debate over the last decade about whether GCA and TAK represent two different diseases, or are age-associated different clinical phenotypes of the same disease. On the other hand, there are differences regarding epidemiology, several clinical features (eg, polymyalgia rheumatica in GCA) and treatment. The aim of this review is to present the latest data regarding this question and to shed some light on the differences and similarities between GCA and TAK regarding epidemiology, genetics, pathogenesis, histopathology, clinical presentation, imaging and treatment. The existing data in literature support the opinion that GCA and TAK are different clinical entities. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mediterranean Journal of Rheumatology
volume
31
issue
2
pages
174 - 182
publisher
Greek Rheumatology Society and Professional Association of Rheumatologists
external identifiers
  • pmid:32676554
  • scopus:85106545562
ISSN
2529-198X
DOI
10.31138/mjr.31.2.174
language
English
LU publication?
yes
id
28664f0c-2051-43f8-8162-716193905d59
alternative location
http://www.mjrheum.org/assets/files/792/file240_1158.pdf
date added to LUP
2020-07-02 21:48:01
date last changed
2022-04-18 23:15:20
@article{28664f0c-2051-43f8-8162-716193905d59,
  abstract     = {{Giant cell arteritis (GCA) and Takayasu Arteritis (TAK) are two systemic granulomatous vasculitides affecting medium- and large-sized arteries. Similarities in GCA and TAK regarding the clinical presentation, the systemic inflammatory response and the distribution of the arterial lesions, have triggered a debate over the last decade about whether GCA and TAK represent two different diseases, or are age-associated different clinical phenotypes of the same disease. On the other hand, there are differences regarding epidemiology, several clinical features (eg, polymyalgia rheumatica in GCA) and treatment. The aim of this review is to present the latest data regarding this question and to shed some light on the differences and similarities between GCA and TAK regarding epidemiology, genetics, pathogenesis, histopathology, clinical presentation, imaging and treatment. The existing data in literature support the opinion that GCA and TAK are different clinical entities.}},
  author       = {{Stamatis, Pavlos}},
  issn         = {{2529-198X}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{174--182}},
  publisher    = {{Greek Rheumatology Society and Professional Association of Rheumatologists}},
  series       = {{Mediterranean Journal of Rheumatology}},
  title        = {{Giant Cell Arteritis versus Takayasu Arteritis: An Update}},
  url          = {{http://dx.doi.org/10.31138/mjr.31.2.174}},
  doi          = {{10.31138/mjr.31.2.174}},
  volume       = {{31}},
  year         = {{2020}},
}