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Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus

Sjowall, C; Bengtsson, Anders LU ; Sturfelt, Gunnar LU and Skogh, T (2004) In Arthritis Research and Therapy 6(2). p.87-94
Abstract
This study was performed to investigate the relation between IgG autoantibodies against human C-reactive protein (antiCRP) and disease activity measures in serial serum samples from 10 patients with systemic lupus erythematosus (SLE), of whom four had active kidney involvement during the study period. The presence of anti-CRP was analysed by enzyme-linked immunosorbent assay. The cut-off for positive anti-CRP test was set at the 95th centile of 100 healthy blood donor sera. Specificity of the anti-CRP antibody binding was evaluated by preincubating patient sera with either native or monomeric CRP. Disease activity was determined by the SLE disease activity index (SLEDAI), serum levels of CRP, anti-DNA antibodies, complement components and... (More)
This study was performed to investigate the relation between IgG autoantibodies against human C-reactive protein (antiCRP) and disease activity measures in serial serum samples from 10 patients with systemic lupus erythematosus (SLE), of whom four had active kidney involvement during the study period. The presence of anti-CRP was analysed by enzyme-linked immunosorbent assay. The cut-off for positive anti-CRP test was set at the 95th centile of 100 healthy blood donor sera. Specificity of the anti-CRP antibody binding was evaluated by preincubating patient sera with either native or monomeric CRP. Disease activity was determined by the SLE disease activity index (SLEDAI), serum levels of CRP, anti-DNA antibodies, complement components and blood cell counts. Of 50 serum samples, 20 (40%) contained antibodies reactive with monomeric CRP, and 7 of 10 patients were positive on at least one occasion during the study. All patients with active lupus nephritis were positive for anti-CRP at flare. Frequent correlations between anti-CRP levels and disease activity measures were observed in anti-CRP-positive individuals. Accumulated anti-CRP data from all patients were positively correlated with SLEDAI scores and anti-DNA antibody levels, whereas significant inverse relationships were noted for complement factors C1q, C3 and C4, and for lymphocyte counts. This study confirms the high prevalence of anti-CRP autoantibodies in SLE and that the antibody levels are correlated with clinical and laboratory disease activity measures. This indicates that anti-CRP antibodies might have biological functions of pathogenetic interest in SLE. Further prospective clinical studies and experimental studies on effects mediated by anti-CRP antibodies are warranted. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lupus erythematosus, systemic, SLEDAI, disease activity, autoantibodies, C-reactive protein
in
Arthritis Research and Therapy
volume
6
issue
2
pages
87 - 94
publisher
BioMed Central
external identifiers
  • wos:000189035200002
  • scopus:27344435590
ISSN
1478-6362
DOI
10.1186/ar1032
language
English
LU publication?
yes
id
bdc5ade5-8c74-4a68-b3a2-7d40384be993 (old id 287427)
date added to LUP
2007-11-01 09:20:35
date last changed
2017-12-03 03:24:20
@article{bdc5ade5-8c74-4a68-b3a2-7d40384be993,
  abstract     = {This study was performed to investigate the relation between IgG autoantibodies against human C-reactive protein (antiCRP) and disease activity measures in serial serum samples from 10 patients with systemic lupus erythematosus (SLE), of whom four had active kidney involvement during the study period. The presence of anti-CRP was analysed by enzyme-linked immunosorbent assay. The cut-off for positive anti-CRP test was set at the 95th centile of 100 healthy blood donor sera. Specificity of the anti-CRP antibody binding was evaluated by preincubating patient sera with either native or monomeric CRP. Disease activity was determined by the SLE disease activity index (SLEDAI), serum levels of CRP, anti-DNA antibodies, complement components and blood cell counts. Of 50 serum samples, 20 (40%) contained antibodies reactive with monomeric CRP, and 7 of 10 patients were positive on at least one occasion during the study. All patients with active lupus nephritis were positive for anti-CRP at flare. Frequent correlations between anti-CRP levels and disease activity measures were observed in anti-CRP-positive individuals. Accumulated anti-CRP data from all patients were positively correlated with SLEDAI scores and anti-DNA antibody levels, whereas significant inverse relationships were noted for complement factors C1q, C3 and C4, and for lymphocyte counts. This study confirms the high prevalence of anti-CRP autoantibodies in SLE and that the antibody levels are correlated with clinical and laboratory disease activity measures. This indicates that anti-CRP antibodies might have biological functions of pathogenetic interest in SLE. Further prospective clinical studies and experimental studies on effects mediated by anti-CRP antibodies are warranted.},
  author       = {Sjowall, C and Bengtsson, Anders and Sturfelt, Gunnar and Skogh, T},
  issn         = {1478-6362},
  keyword      = {lupus erythematosus,systemic,SLEDAI,disease activity,autoantibodies,C-reactive protein},
  language     = {eng},
  number       = {2},
  pages        = {87--94},
  publisher    = {BioMed Central},
  series       = {Arthritis Research and Therapy},
  title        = {Serum levels of autoantibodies against monomeric C-reactive protein are correlated with disease activity in systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1186/ar1032},
  volume       = {6},
  year         = {2004},
}