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Peptide nanotube formation: a crystal growth process

Cenker, Celen LU ; Bomans, Paul H. H.; Friedrich, Heiner; Dedeoglu, Burcu; Aviyente, Viktorya; Olsson, Ulf LU ; Sommerdijk, Nico A. J. M. and Bucak, Seyda (2012) In Soft Matter 8(28). p.7463-7470
Abstract
Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tubes in fact is a crystal growth process, involving different mechanisms depending on the conditions used. Inorganic crystals have been demonstrated to form not only through ion-by-ion addition but also through non-classical mechanisms including oriented attachment. Here we show an organic crystalline material that can form through... (More)
Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tubes in fact is a crystal growth process, involving different mechanisms depending on the conditions used. Inorganic crystals have been demonstrated to form not only through ion-by-ion addition but also through non-classical mechanisms including oriented attachment. Here we show an organic crystalline material that can form through molecule-by-molecule growth as well as through oriented attachment. We discuss the mechanisms in relation to the supersaturation levels of the peptide solutions and the molecular interactions between the peptide molecules in the tubular assemblies. The proposed mechanisms are supported by semi-empirical molecular orbital calculations and time resolved dissolution experiments. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Soft Matter
volume
8
issue
28
pages
7463 - 7470
publisher
Royal Society of Chemistry
external identifiers
  • wos:000305764800019
  • scopus:84869596512
ISSN
1744-6848
DOI
10.1039/c2sm25671a
language
English
LU publication?
yes
id
082c6231-7a8c-4a16-940b-055b076e5f6f (old id 2883788)
date added to LUP
2012-07-24 15:58:40
date last changed
2017-10-08 04:01:36
@article{082c6231-7a8c-4a16-940b-055b076e5f6f,
  abstract     = {Above its critical aggregation concentration the tfa salt of the peptide A(6)K self-assembles into micron long, hollow nanotubes with uniform diameters of 52 nm and crystalline order. Here we combine the use of SAXS with cryoTEM and cryo-electron tomography (cryoET, 3D cryoTEM) to study the formation process of the 2D crystalline A(6)K nanotubes. This study reveals that the formation of these tubes in fact is a crystal growth process, involving different mechanisms depending on the conditions used. Inorganic crystals have been demonstrated to form not only through ion-by-ion addition but also through non-classical mechanisms including oriented attachment. Here we show an organic crystalline material that can form through molecule-by-molecule growth as well as through oriented attachment. We discuss the mechanisms in relation to the supersaturation levels of the peptide solutions and the molecular interactions between the peptide molecules in the tubular assemblies. The proposed mechanisms are supported by semi-empirical molecular orbital calculations and time resolved dissolution experiments.},
  author       = {Cenker, Celen and Bomans, Paul H. H. and Friedrich, Heiner and Dedeoglu, Burcu and Aviyente, Viktorya and Olsson, Ulf and Sommerdijk, Nico A. J. M. and Bucak, Seyda},
  issn         = {1744-6848},
  language     = {eng},
  number       = {28},
  pages        = {7463--7470},
  publisher    = {Royal Society of Chemistry},
  series       = {Soft Matter},
  title        = {Peptide nanotube formation: a crystal growth process},
  url          = {http://dx.doi.org/10.1039/c2sm25671a},
  volume       = {8},
  year         = {2012},
}