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Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease

Daborg, Jonny; Andreasson, Ulf; Pekna, Marcela; Lautner, Ronald; Hanse, Eric; Minthon, Lennart LU ; Blennow, Kaj; Hansson, Oskar LU and Zetterberg, Henrik (2012) In Journal of Neural Transmission 119(7). p.789-797
Abstract
Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers A beta 42, T-tau... (More)
Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers A beta 42, T-tau and P-tau. We found elevated CSF levels of C3 and C4 in AD compared with MCI without progression to AD, and elevated CSF levels of CR1 in MCI-AD and AD when these groups were merged. These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, Complement, Biomarkers, C3, C4, CR1
in
Journal of Neural Transmission
volume
119
issue
7
pages
789 - 797
publisher
Springer
external identifiers
  • wos:000305525800008
  • scopus:84863464104
ISSN
0300-9564
DOI
10.1007/s00702-012-0797-8
language
English
LU publication?
yes
id
bab03b2e-d779-4a25-a886-8f07844d9964 (old id 2883904)
date added to LUP
2012-08-01 09:41:54
date last changed
2017-10-01 04:08:30
@article{bab03b2e-d779-4a25-a886-8f07844d9964,
  abstract     = {Alzheimer's disease (AD) is strongly associated with loss of synapses. The complement system has been shown to be involved in synaptic elimination. Several studies point to an association between AD and the complement system. The purpose of this study was to examine the association of cerebrospinal fluid (CSF) levels of complement components 3 and 4 (C3 and C4, respectively), and complement receptor 1 (CR1) with AD in 43 patients with AD plus dementia, 42 patients with mild cognitive impairment (MCI) who progressed to AD during follow-up (MCI-AD), 42 patients with stable MCI and 44 controls. Complement levels were also applied in a multivariate model to determine if they provided any added value to the core AD biomarkers A beta 42, T-tau and P-tau. We found elevated CSF levels of C3 and C4 in AD compared with MCI without progression to AD, and elevated CSF levels of CR1 in MCI-AD and AD when these groups were merged. These results provide support for aberrant complement regulation as a part in the AD process, but the changes are not diagnostically useful.},
  author       = {Daborg, Jonny and Andreasson, Ulf and Pekna, Marcela and Lautner, Ronald and Hanse, Eric and Minthon, Lennart and Blennow, Kaj and Hansson, Oskar and Zetterberg, Henrik},
  issn         = {0300-9564},
  keyword      = {Alzheimer's disease,Complement,Biomarkers,C3,C4,CR1},
  language     = {eng},
  number       = {7},
  pages        = {789--797},
  publisher    = {Springer},
  series       = {Journal of Neural Transmission},
  title        = {Cerebrospinal fluid levels of complement proteins C3, C4 and CR1 in Alzheimer's disease},
  url          = {http://dx.doi.org/10.1007/s00702-012-0797-8},
  volume       = {119},
  year         = {2012},
}