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Determination of optical scattering properties of highly-scattering media in optical coherence tomography images

Levitz, D; Thrane, L; Frosz, MH; Andersen, PE; Andersen, CB; Valanciunaite, J; Swartling, Johannes LU ; Andersson-Engels, Stefan LU and Hansen, PR (2004) In Optics Express 12(2). p.249-259
Abstract
We developed a new algorithm that fits optical coherence tomography (OCT) signals as a function of depth to a general theoretical OCT model which takes into account multiple scattering effects. With use of this algorithm, it was possible to extract both the scattering coefficient and anisotropy factor from a particular region of interest in an OCT image. The extraction algorithm was evaluated against measurements from an integrating sphere on a set of tissue phantoms and yielded valid results. Finally, a preliminary ex vivo OCT investigation on human aortic specimen indicated that the algorithm may contribute importantly to differentiation between normal and atherosclerotic arteries. We conclude that this algorithm may facilitate tissue... (More)
We developed a new algorithm that fits optical coherence tomography (OCT) signals as a function of depth to a general theoretical OCT model which takes into account multiple scattering effects. With use of this algorithm, it was possible to extract both the scattering coefficient and anisotropy factor from a particular region of interest in an OCT image. The extraction algorithm was evaluated against measurements from an integrating sphere on a set of tissue phantoms and yielded valid results. Finally, a preliminary ex vivo OCT investigation on human aortic specimen indicated that the algorithm may contribute importantly to differentiation between normal and atherosclerotic arteries. We conclude that this algorithm may facilitate tissue characterization by OCT. (C) 2004 Optical Society of America. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
12
issue
2
pages
249 - 259
publisher
OSA
external identifiers
  • wos:000188383200003
  • scopus:1942487924
ISSN
1094-4087
language
English
LU publication?
yes
id
7dffa0d1-14ab-4fbb-8b70-8581bff488a5 (old id 288578)
alternative location
http://www.opticsinfobase.org/abstract.cfm?URI=oe-12-2-249
date added to LUP
2007-10-24 12:44:18
date last changed
2017-11-05 04:22:51
@article{7dffa0d1-14ab-4fbb-8b70-8581bff488a5,
  abstract     = {We developed a new algorithm that fits optical coherence tomography (OCT) signals as a function of depth to a general theoretical OCT model which takes into account multiple scattering effects. With use of this algorithm, it was possible to extract both the scattering coefficient and anisotropy factor from a particular region of interest in an OCT image. The extraction algorithm was evaluated against measurements from an integrating sphere on a set of tissue phantoms and yielded valid results. Finally, a preliminary ex vivo OCT investigation on human aortic specimen indicated that the algorithm may contribute importantly to differentiation between normal and atherosclerotic arteries. We conclude that this algorithm may facilitate tissue characterization by OCT. (C) 2004 Optical Society of America.},
  author       = {Levitz, D and Thrane, L and Frosz, MH and Andersen, PE and Andersen, CB and Valanciunaite, J and Swartling, Johannes and Andersson-Engels, Stefan and Hansen, PR},
  issn         = {1094-4087},
  language     = {eng},
  number       = {2},
  pages        = {249--259},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Determination of optical scattering properties of highly-scattering media in optical coherence tomography images},
  volume       = {12},
  year         = {2004},
}