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Fruits and vegetables and prostate cancer: No association among 1,104 cases in a prospective study of 130,544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Key, TJ; Allen, N; Appleby, P; Overvad, K; Tjonneland, A; Miller, A; Boeing, H; Karalis, D; Psaltopoulou, T and Berrino, F, et al. (2004) In International Journal of Cancer 109(1). p.119-124
Abstract
We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130,544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were 1,104 incident cases of prostate cancer. The associations of consumption of total fruits, total vegetables, cruciferous vegetables and combined total fruits and vegetables with prostate cancer risk were examined using Cox regression, stratified for recruitment center and adjusted for height, weight and energy intake. There was a wide range in... (More)
We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130,544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were 1,104 incident cases of prostate cancer. The associations of consumption of total fruits, total vegetables, cruciferous vegetables and combined total fruits and vegetables with prostate cancer risk were examined using Cox regression, stratified for recruitment center and adjusted for height, weight and energy intake. There was a wide range in consumption of fruits and vegetables: mean intakes (g/day) in the bottom and top fifths of the distribution, as estimated from 24-hr recalls in a subsample of participants, were 53.2 and 410.7 for fruits, 97.1 and 242.1 for vegetables and 169.0 and 633.7 for fruits and vegetables combined. No significant associations between fruit and vegetable consumption and prostate cancer risk were observed. Relative risks (95% confidence intervals) in the top fifth of the distribution of consumption, compared to the bottom fifth, were 1.06 (0.84-1.34) for total fruits, 1.00 (0.81-1.22) for total vegetables and 1.00 (0.79-1.26) for total fruits and vegetables combined; intake of cruciferous vegetables was not associated with risk. These results suggest that total consumption of fruits and vegetables is not associated with the risk for prostate cancer. (C) 2003 Wiley-Liss, Inc. (Less)
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keywords
vegetables, fruits, prostate cancer, etiology, cruciferous vegetables
in
International Journal of Cancer
volume
109
issue
1
pages
119 - 124
publisher
John Wiley & Sons
external identifiers
  • pmid:14735477
  • wos:000188736300017
  • scopus:10744230822
ISSN
0020-7136
DOI
10.1002/ijc.11671
language
English
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yes
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4d5a51fd-d3df-4505-9f91-1e5af5aa27a9 (old id 288701)
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2007-10-23 18:24:49
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2017-08-27 03:50:13
@article{4d5a51fd-d3df-4505-9f91-1e5af5aa27a9,
  abstract     = {We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130,544 men in 7 countries recruited into EPIC between 1993 and 1999. After an average of 4.8 years of follow-up, there were 1,104 incident cases of prostate cancer. The associations of consumption of total fruits, total vegetables, cruciferous vegetables and combined total fruits and vegetables with prostate cancer risk were examined using Cox regression, stratified for recruitment center and adjusted for height, weight and energy intake. There was a wide range in consumption of fruits and vegetables: mean intakes (g/day) in the bottom and top fifths of the distribution, as estimated from 24-hr recalls in a subsample of participants, were 53.2 and 410.7 for fruits, 97.1 and 242.1 for vegetables and 169.0 and 633.7 for fruits and vegetables combined. No significant associations between fruit and vegetable consumption and prostate cancer risk were observed. Relative risks (95% confidence intervals) in the top fifth of the distribution of consumption, compared to the bottom fifth, were 1.06 (0.84-1.34) for total fruits, 1.00 (0.81-1.22) for total vegetables and 1.00 (0.79-1.26) for total fruits and vegetables combined; intake of cruciferous vegetables was not associated with risk. These results suggest that total consumption of fruits and vegetables is not associated with the risk for prostate cancer. (C) 2003 Wiley-Liss, Inc.},
  author       = {Key, TJ and Allen, N and Appleby, P and Overvad, K and Tjonneland, A and Miller, A and Boeing, H and Karalis, D and Psaltopoulou, T and Berrino, F and Palli, D and Panico, S and Tumino, R and Vineis, P and Bueno-de-Mesquita, HB and Kiemeney, L and Peeters, PHM and Martinez, C and Dorronsoro, M and Gonzalez, CA and Chirlaque, MD and Quiros, JR and Ardanaz, E and Berglund, Göran and Egevad, L and Hallmans, G and Stattin, P and Bingham, S and Day, N and Gann, P and Kaaks, R and Ferrari, P and Riboli, E},
  issn         = {0020-7136},
  keyword      = {vegetables,fruits,prostate cancer,etiology,cruciferous vegetables},
  language     = {eng},
  number       = {1},
  pages        = {119--124},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fruits and vegetables and prostate cancer: No association among 1,104 cases in a prospective study of 130,544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC)},
  url          = {http://dx.doi.org/10.1002/ijc.11671},
  volume       = {109},
  year         = {2004},
}