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The Therapeutic Relationship and Adherence to Antipsychotic Medication in Schizophrenia

McCabe, Rosemarie; Bullenkamp, Jens; Hansson, Lars LU ; Lauber, Christoph; Martinez-Leal, Rafael; Roessler, Wulf; Salize, Hans Joachim; Svensson, Bengt LU ; Torres-Gonzalez, Francisco and van den Brink, Rob, et al. (2012) In PLoS ONE 7(4).
Abstract
Objective: Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adherence to antipsychotics in patients with schizophrenia. Methods: 134 clinicians and 507 of their patients with schizophrenia or a related psychotic disorder participated in a European multi-centre study. A logistic regression model examined how the TR as rated by patients and by clinicians is associated with medication adherence, adjusting for clinician clustering and symptom severity. Results: Patient and clinician ratings of the TR were weakly inter-correlated... (More)
Objective: Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adherence to antipsychotics in patients with schizophrenia. Methods: 134 clinicians and 507 of their patients with schizophrenia or a related psychotic disorder participated in a European multi-centre study. A logistic regression model examined how the TR as rated by patients and by clinicians is associated with medication adherence, adjusting for clinician clustering and symptom severity. Results: Patient and clinician ratings of the TR were weakly inter-correlated (r(s) = 0.13, p = 0.004), but each was independently linked with better adherence. After adjusting for patient rated TR and symptom severity, each unit increase in clinician rated TR was associated with an increase of the odds ratio of good compliance by 65.9% (95% CI: 34.6% to 104.5%). After adjusting for clinician rated TR and symptom severity, for each unit increase in patient rated TR the odds ratio of good compliance was increased by 20.8% (95% CI: 4.4% to 39.8%). Conclusions: A better TR is associated with better adherence to medication among patients with schizophrenia. Patients' and clinicians' perspectives of the TR are both important, but may reflect distinct aspects. (Less)
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PLoS ONE
volume
7
issue
4
publisher
Public Library of Science
external identifiers
  • wos:000305336000122
  • scopus:84860442673
ISSN
1932-6203
DOI
10.1371/journal.pone.0036080
language
English
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yes
id
fc8a22a6-bdd8-48dc-83cb-800311f0bca1 (old id 2890870)
date added to LUP
2012-08-01 08:54:59
date last changed
2017-10-01 04:32:24
@article{fc8a22a6-bdd8-48dc-83cb-800311f0bca1,
  abstract     = {Objective: Previous research has shown that a better therapeutic relationship (TR) predicts more positive attitudes towards antipsychotic medication, but did not address whether it is also linked with actual adherence. This study investigated whether the TR is associated with adherence to antipsychotics in patients with schizophrenia. Methods: 134 clinicians and 507 of their patients with schizophrenia or a related psychotic disorder participated in a European multi-centre study. A logistic regression model examined how the TR as rated by patients and by clinicians is associated with medication adherence, adjusting for clinician clustering and symptom severity. Results: Patient and clinician ratings of the TR were weakly inter-correlated (r(s) = 0.13, p = 0.004), but each was independently linked with better adherence. After adjusting for patient rated TR and symptom severity, each unit increase in clinician rated TR was associated with an increase of the odds ratio of good compliance by 65.9% (95% CI: 34.6% to 104.5%). After adjusting for clinician rated TR and symptom severity, for each unit increase in patient rated TR the odds ratio of good compliance was increased by 20.8% (95% CI: 4.4% to 39.8%). Conclusions: A better TR is associated with better adherence to medication among patients with schizophrenia. Patients' and clinicians' perspectives of the TR are both important, but may reflect distinct aspects.},
  author       = {McCabe, Rosemarie and Bullenkamp, Jens and Hansson, Lars and Lauber, Christoph and Martinez-Leal, Rafael and Roessler, Wulf and Salize, Hans Joachim and Svensson, Bengt and Torres-Gonzalez, Francisco and van den Brink, Rob and Wiersma, Durk and Priebe, Stefan},
  issn         = {1932-6203},
  language     = {eng},
  number       = {4},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {The Therapeutic Relationship and Adherence to Antipsychotic Medication in Schizophrenia},
  url          = {http://dx.doi.org/10.1371/journal.pone.0036080},
  volume       = {7},
  year         = {2012},
}