Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
(2022) In International Journal of Epidemiology 50(6). p.1914-1926- Abstract
BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.
METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.
RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years... (More)
BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.
METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.
RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85).
CONCLUSION: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2022-01-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Body Mass Index, Breast Neoplasms/epidemiology, Female, Humans, Middle Aged, Prospective Studies, Risk Factors, Weight Gain, Young Adult, long-term weight change, breast cancer, cohort study
- in
- International Journal of Epidemiology
- volume
- 50
- issue
- 6
- pages
- 13 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85122733728
- pmid:34999853
- ISSN
- 1464-3685
- DOI
- 10.1093/ije/dyab032
- language
- English
- LU publication?
- yes
- additional info
- © The Author(s) 2021. Published by Oxford University Press on behalf of the International Epidemiological Association.
- id
- 28ba7ee5-eb4f-4658-b962-67f518bad1dd
- date added to LUP
- 2023-10-25 16:51:07
- date last changed
- 2024-04-19 02:53:43
@article{28ba7ee5-eb4f-4658-b962-67f518bad1dd,
abstract = {{<p>BACKGROUND: The role of obesity and weight change in breast-cancer development is complex and incompletely understood. We investigated long-term weight change and breast-cancer risk by body mass index (BMI) at age 20 years, menopausal status, hormone replacement therapy (HRT) and hormone-receptor status.</p><p>METHODS: Using data on weight collected at three different time points from women who participated in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the association between weight change from age 20 years until middle adulthood and risk of breast cancer.</p><p>RESULTS: In total, 150 257 women with a median age of 51 years at cohort entry were followed for an average of 14 years (standard deviation = 3.9) during which 6532 breast-cancer cases occurred. Compared with women with stable weight (±2.5 kg), long-term weight gain >10 kg was positively associated with postmenopausal breast-cancer risk in women who were lean at age 20 [hazard ratio (HR) = 1.42; 95% confidence interval 1.22-1.65] in ever HRT users (HR = 1.23; 1.04-1.44), in never HRT users (HR = 1.40; 1.16-1.68) and in oestrogen-and-progesterone-receptor-positive (ER+PR+) breast cancer (HR = 1.46; 1.15-1.85).</p><p>CONCLUSION: Long-term weight gain was positively associated with postmenopausal breast cancer in women who were lean at age 20, both in HRT ever users and non-users, and hormone-receptor-positive breast cancer.</p>}},
author = {{Ellingjord-Dale, Merete and Christakoudi, Sofia and Weiderpass, Elisabete and Panico, Salvatore and Dossus, Laure and Olsen, Anja and Tjønneland, Anne and Kaaks, Rudolf and Schulze, Matthias B and Masala, Giovanna and Gram, Inger T and Skeie, Guri and Rosendahl, Ann H and Sund, Malin and Key, Tim and Ferrari, Pietro and Gunter, Marc and Heath, Alicia K and Tsilidis, Konstantinos K and Riboli, Elio}},
issn = {{1464-3685}},
keywords = {{Adult; Body Mass Index; Breast Neoplasms/epidemiology; Female; Humans; Middle Aged; Prospective Studies; Risk Factors; Weight Gain; Young Adult; long-term weight change; breast cancer; cohort study}},
language = {{eng}},
month = {{01}},
number = {{6}},
pages = {{1914--1926}},
publisher = {{Oxford University Press}},
series = {{International Journal of Epidemiology}},
title = {{Long-term weight change and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study}},
url = {{http://dx.doi.org/10.1093/ije/dyab032}},
doi = {{10.1093/ije/dyab032}},
volume = {{50}},
year = {{2022}},
}