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Clinical photon-counting CT in living patients detects intraplaque haemorrhage and thrombus in carotid plaques

Shami, Annelie LU orcid ; Sun, Jiangming LU orcid ; Celander, My LU ; Persson, Ana LU ; Edsfeldt, Andreas LU orcid ; Bech, Martin LU orcid ; Aurumskjöld, Marie-Louise LU and Gonçalves, Isabel LU orcid (2025) In European Heart Journal p.1-4
Abstract

In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clinical routine acquisition settings, with many energy levels to detect atherosclerotic plaque features relevant for plaque rupture (which underlies most strokes and myocardial infarctions). Deepened knowledge of the atherosclerotic plaque features using non-invasive, high-resolution techniques as the recent PCCT is a crucial step towards... (More)

In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clinical routine acquisition settings, with many energy levels to detect atherosclerotic plaque features relevant for plaque rupture (which underlies most strokes and myocardial infarctions). Deepened knowledge of the atherosclerotic plaque features using non-invasive, high-resolution techniques as the recent PCCT is a crucial step towards detecting rupture-prone plaques and, thus, improve risk stratification for diagnosis, prevention or monitoring of therapeutic interventions.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
European Heart Journal
article number
ehaf707
pages
1 - 4
publisher
Oxford University Press
external identifiers
  • pmid:40878371
ISSN
1522-9645
DOI
10.1093/eurheartj/ehaf707
language
English
LU publication?
yes
additional info
© The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
id
28dc68e3-9a96-419d-a2c7-85138fcba6d8
date added to LUP
2025-09-26 20:37:14
date last changed
2025-09-30 03:11:26
@article{28dc68e3-9a96-419d-a2c7-85138fcba6d8,
  abstract     = {{<p>In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clinical routine acquisition settings, with many energy levels to detect atherosclerotic plaque features relevant for plaque rupture (which underlies most strokes and myocardial infarctions). Deepened knowledge of the atherosclerotic plaque features using non-invasive, high-resolution techniques as the recent PCCT is a crucial step towards detecting rupture-prone plaques and, thus, improve risk stratification for diagnosis, prevention or monitoring of therapeutic interventions.</p>}},
  author       = {{Shami, Annelie and Sun, Jiangming and Celander, My and Persson, Ana and Edsfeldt, Andreas and Bech, Martin and Aurumskjöld, Marie-Louise and Gonçalves, Isabel}},
  issn         = {{1522-9645}},
  language     = {{eng}},
  month        = {{08}},
  pages        = {{1--4}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal}},
  title        = {{Clinical photon-counting CT in living patients detects intraplaque haemorrhage and thrombus in carotid plaques}},
  url          = {{http://dx.doi.org/10.1093/eurheartj/ehaf707}},
  doi          = {{10.1093/eurheartj/ehaf707}},
  year         = {{2025}},
}