Clinical photon-counting CT in living patients detects intraplaque haemorrhage and thrombus in carotid plaques
(2025) In European Heart Journal p.1-4- Abstract
In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clinical routine acquisition settings, with many energy levels to detect atherosclerotic plaque features relevant for plaque rupture (which underlies most strokes and myocardial infarctions). Deepened knowledge of the atherosclerotic plaque features using non-invasive, high-resolution techniques as the recent PCCT is a crucial step towards... (More)
In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clinical routine acquisition settings, with many energy levels to detect atherosclerotic plaque features relevant for plaque rupture (which underlies most strokes and myocardial infarctions). Deepened knowledge of the atherosclerotic plaque features using non-invasive, high-resolution techniques as the recent PCCT is a crucial step towards detecting rupture-prone plaques and, thus, improve risk stratification for diagnosis, prevention or monitoring of therapeutic interventions.
(Less)
- author
- Shami, Annelie
LU
; Sun, Jiangming LU
; Celander, My LU ; Persson, Ana LU ; Edsfeldt, Andreas LU
; Bech, Martin LU
; Aurumskjöld, Marie-Louise LU and Gonçalves, Isabel LU
- organization
-
- Cardiovascular Research - Translational Studies (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- X-ray Phase Contrast (research group)
- Medical Radiation Physics, Lund
- WCMM-Wallenberg Centre for Molecular Medicine
- LTH Profile Area: Photon Science and Technology
- LTH Profile Area: Engineering Health
- Medical Radiation Physics, Malmö (research group)
- EpiHealth: Epidemiology for Health
- publishing date
- 2025-08-29
- type
- Contribution to journal
- publication status
- epub
- subject
- in
- European Heart Journal
- article number
- ehaf707
- pages
- 1 - 4
- publisher
- Oxford University Press
- external identifiers
-
- pmid:40878371
- ISSN
- 1522-9645
- DOI
- 10.1093/eurheartj/ehaf707
- language
- English
- LU publication?
- yes
- additional info
- © The Author(s) 2025. Published by Oxford University Press on behalf of the European Society of Cardiology.
- id
- 28dc68e3-9a96-419d-a2c7-85138fcba6d8
- date added to LUP
- 2025-09-26 20:37:14
- date last changed
- 2025-09-29 07:40:37
@article{28dc68e3-9a96-419d-a2c7-85138fcba6d8, abstract = {{<p>In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clinical routine acquisition settings, with many energy levels to detect atherosclerotic plaque features relevant for plaque rupture (which underlies most strokes and myocardial infarctions). Deepened knowledge of the atherosclerotic plaque features using non-invasive, high-resolution techniques as the recent PCCT is a crucial step towards detecting rupture-prone plaques and, thus, improve risk stratification for diagnosis, prevention or monitoring of therapeutic interventions.</p>}}, author = {{Shami, Annelie and Sun, Jiangming and Celander, My and Persson, Ana and Edsfeldt, Andreas and Bech, Martin and Aurumskjöld, Marie-Louise and Gonçalves, Isabel}}, issn = {{1522-9645}}, language = {{eng}}, month = {{08}}, pages = {{1--4}}, publisher = {{Oxford University Press}}, series = {{European Heart Journal}}, title = {{Clinical photon-counting CT in living patients detects intraplaque haemorrhage and thrombus in carotid plaques}}, url = {{http://dx.doi.org/10.1093/eurheartj/ehaf707}}, doi = {{10.1093/eurheartj/ehaf707}}, year = {{2025}}, }