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Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of a DNA repair enhancing cat's claw extract

Pero, Ronald LU ; Giampapa, V and Vojdani, A (2002) In Journal of Anti-Aging Medicine 5(4). p.345-353
Abstract
Dietary supplements, designed to fortify the antioxidant status of human metabolism, are intended to provide nutritional support against the aging process. The strategy is based on the observation that environmental and metabolic sources of oxidatively generated free radicals damage key macromolecules, such as DNA, that in turn alter physiologic processes, and in turn may contribute to aging and age-related diseases such as cancer, as well as cardiovascular and immunologic disorders. This study investigates whether a commercially available, broad spectrum anti-oxidant formulation containing 12 vitamins, 8 minerals, 2 agents to provide "blood sugar/insulin support," 3 botanical antioxidants, one methylating factor, two "fat metabolizers,"... (More)
Dietary supplements, designed to fortify the antioxidant status of human metabolism, are intended to provide nutritional support against the aging process. The strategy is based on the observation that environmental and metabolic sources of oxidatively generated free radicals damage key macromolecules, such as DNA, that in turn alter physiologic processes, and in turn may contribute to aging and age-related diseases such as cancer, as well as cardiovascular and immunologic disorders. This study investigates whether a commercially available, broad spectrum anti-oxidant formulation containing 12 vitamins, 8 minerals, 2 agents to provide "blood sugar/insulin support," 3 botanical antioxidants, one methylating factor, two "fat metabolizers," an "absorption enhancer," a "brain enhancer," a "whole food" ingredient, 2 "cellular energizers," a nucleotide precursor, 2 amino acids, a fatty acid complex, a "probiotic complex," and a digestive enzyme (formula one) could be improved through inclusion of an ingredient that enhances DNA repair (C-Med-100). The two formulations were compared using four intermediate endpoint biomarkers: 8-OH guanine DNA adducts, serum thiols, and Interleukins 1a and 1. Whereas both were shown to be effective at reducing DNA damage, the second, more inclusive formulation appeared to be more effective. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Anti-Aging Medicine
volume
5
issue
4
pages
345 - 353
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000187885300005
  • scopus:84968460519
ISSN
1094-5458
DOI
10.1089/109454502763485467
language
English
LU publication?
yes
id
7c2f172d-edef-43fb-87ff-27c2c1f208f0 (old id 290078)
date added to LUP
2007-11-08 12:56:35
date last changed
2017-11-05 04:33:37
@article{7c2f172d-edef-43fb-87ff-27c2c1f208f0,
  abstract     = {Dietary supplements, designed to fortify the antioxidant status of human metabolism, are intended to provide nutritional support against the aging process. The strategy is based on the observation that environmental and metabolic sources of oxidatively generated free radicals damage key macromolecules, such as DNA, that in turn alter physiologic processes, and in turn may contribute to aging and age-related diseases such as cancer, as well as cardiovascular and immunologic disorders. This study investigates whether a commercially available, broad spectrum anti-oxidant formulation containing 12 vitamins, 8 minerals, 2 agents to provide "blood sugar/insulin support," 3 botanical antioxidants, one methylating factor, two "fat metabolizers," an "absorption enhancer," a "brain enhancer," a "whole food" ingredient, 2 "cellular energizers," a nucleotide precursor, 2 amino acids, a fatty acid complex, a "probiotic complex," and a digestive enzyme (formula one) could be improved through inclusion of an ingredient that enhances DNA repair (C-Med-100). The two formulations were compared using four intermediate endpoint biomarkers: 8-OH guanine DNA adducts, serum thiols, and Interleukins 1a and 1. Whereas both were shown to be effective at reducing DNA damage, the second, more inclusive formulation appeared to be more effective.},
  author       = {Pero, Ronald and Giampapa, V and Vojdani, A},
  issn         = {1094-5458},
  language     = {eng},
  number       = {4},
  pages        = {345--353},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Journal of Anti-Aging Medicine},
  title        = {Comparison of a broad spectrum anti-aging nutritional supplement with and without the addition of a DNA repair enhancing cat's claw extract},
  url          = {http://dx.doi.org/10.1089/109454502763485467},
  volume       = {5},
  year         = {2002},
}