Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes

Nilsson, Christopher LU orcid ; Christensson, Anders LU ; Nilsson, Peter M. LU ; Melander, Olle LU orcid and Bennet, Louise LU orcid (2021) In Scandinavian Journal of Clinical and Laboratory Investigation 81(7). p.573-578
Abstract

Iraqi-born immigrants residing in Sweden exhibit lower blood pressure as well as better renal function despite an overall worse metabolic risk profile in comparison with native Swedes. This may indicate the presence of cardiorenal protective mechanisms in the Middle Eastern population. Hence, the aim of this study was to investigate whether the association between renal function and Pro-Enkephalin (PENK), a biomarker predictive of both acute and chronic kidney dysfunction, differs across ethnicities. The MEDIM population-based study including a cohort of women and men, born in Iraq or Sweden, aged 30–75 years was conducted in Malmö, Sweden, from 2010 to 2012. The study included fasting blood samples, physical examinations and... (More)

Iraqi-born immigrants residing in Sweden exhibit lower blood pressure as well as better renal function despite an overall worse metabolic risk profile in comparison with native Swedes. This may indicate the presence of cardiorenal protective mechanisms in the Middle Eastern population. Hence, the aim of this study was to investigate whether the association between renal function and Pro-Enkephalin (PENK), a biomarker predictive of both acute and chronic kidney dysfunction, differs across ethnicities. The MEDIM population-based study including a cohort of women and men, born in Iraq or Sweden, aged 30–75 years was conducted in Malmö, Sweden, from 2010 to 2012. The study included fasting blood samples, physical examinations and self-administrated questionnaires. Despite significantly better renal function assessed by creatinine-based eGFR in the Iraqi group, levels of PENK did not differ between the groups, (70.0 pmol/L, born in Iraq (n = 1263) vs 71.1, born in Sweden (n = 689), p =.4). However, the association between PENK and renal function was relatively weaker in the Iraqi born group, as supported by a significant interaction between PENK and country of birth (P Interaction= Country of birth x PENK = 0,010). This observational study suggests that the association between renal function and PENK was weaker in Middle Eastern immigrants. This is of interest as PENK may exhibit a direct effect on renal function, however further research is needed including studies on causality.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomarkers, blood pressure, ethnic groups, glomerular filtration rate, kidney function tests
in
Scandinavian Journal of Clinical and Laboratory Investigation
volume
81
issue
7
pages
573 - 578
publisher
Informa Healthcare
external identifiers
  • scopus:85115821787
  • pmid:34581639
ISSN
0036-5513
DOI
10.1080/00365513.2021.1979243
project
AIR Lund - Artificially Intelligent use of Registers
Aspects of ethnicity on blood pressure regulating mechanisms and kidney function
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
The MEDIM project
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 Medisinsk Fysiologisk Forenings Forlag (MFFF).
id
290ce7f3-9aad-4d88-b4b3-020957372ac2
date added to LUP
2021-10-19 18:43:23
date last changed
2024-10-06 06:21:43
@article{290ce7f3-9aad-4d88-b4b3-020957372ac2,
  abstract     = {{<p>Iraqi-born immigrants residing in Sweden exhibit lower blood pressure as well as better renal function despite an overall worse metabolic risk profile in comparison with native Swedes. This may indicate the presence of cardiorenal protective mechanisms in the Middle Eastern population. Hence, the aim of this study was to investigate whether the association between renal function and Pro-Enkephalin (PENK), a biomarker predictive of both acute and chronic kidney dysfunction, differs across ethnicities. The MEDIM population-based study including a cohort of women and men, born in Iraq or Sweden, aged 30–75 years was conducted in Malmö, Sweden, from 2010 to 2012. The study included fasting blood samples, physical examinations and self-administrated questionnaires. Despite significantly better renal function assessed by creatinine-based eGFR in the Iraqi group, levels of PENK did not differ between the groups, (70.0 pmol/L, born in Iraq (n = 1263) vs 71.1, born in Sweden (n = 689), p =.4). However, the association between PENK and renal function was relatively weaker in the Iraqi born group, as supported by a significant interaction between PENK and country of birth (P <sub>Interaction</sub>= Country of birth x PENK = 0,010). This observational study suggests that the association between renal function and PENK was weaker in Middle Eastern immigrants. This is of interest as PENK may exhibit a direct effect on renal function, however further research is needed including studies on causality.</p>}},
  author       = {{Nilsson, Christopher and Christensson, Anders and Nilsson, Peter M. and Melander, Olle and Bennet, Louise}},
  issn         = {{0036-5513}},
  keywords     = {{Biomarkers; blood pressure; ethnic groups; glomerular filtration rate; kidney function tests}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{573--578}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical and Laboratory Investigation}},
  title        = {{Pro-Enkephalin and its association with renal function in Middle Eastern immigrants and native Swedes}},
  url          = {{http://dx.doi.org/10.1080/00365513.2021.1979243}},
  doi          = {{10.1080/00365513.2021.1979243}},
  volume       = {{81}},
  year         = {{2021}},
}