Decreased serum testosterone and free triiodothyronine levels in healthy middle-aged men indicate an age effect at the pituitary level
(1995) In European Journal of Endocrinology 132(6). p.7-663- Abstract
In an attempt to study further the age-specific influence on the hypothalamo-pituitary-gonadal axis as well as the hypothalamo-pituitary-thyroid axis, we have now investigated young and middle-aged men, considering possible confounding factors. Both serum total testosterone, free testosterone and the total ratio of testosterone to sex-hormone binding globulin were significantly lower among middle-aged men as compared with young men (p = 0.02, p = 0.002 and p = 0.0003, respectively). In accordance with these findings there was also a decrease in the luteinizing hormone response to gonadotrophin-releasing hormone in the middle-aged men (p = 0.02). Free testosterone was correlated significantly with the luteinizing hormone response (r =... (More)
In an attempt to study further the age-specific influence on the hypothalamo-pituitary-gonadal axis as well as the hypothalamo-pituitary-thyroid axis, we have now investigated young and middle-aged men, considering possible confounding factors. Both serum total testosterone, free testosterone and the total ratio of testosterone to sex-hormone binding globulin were significantly lower among middle-aged men as compared with young men (p = 0.02, p = 0.002 and p = 0.0003, respectively). In accordance with these findings there was also a decrease in the luteinizing hormone response to gonadotrophin-releasing hormone in the middle-aged men (p = 0.02). Free testosterone was correlated significantly with the luteinizing hormone response (r = 0.32, p = 0.02). Serum free triiodothyronine was significantly higher among young men as compared with middle-aged men (p = 0.002) and the thyrotrophin-releasing hormone-stimulated thyrotrophin response was also higher in the young group compared with the middle-aged group. The present results may indicate that the age effect on serum levels of testosterone and free triiodothyronine is mediated at the pituitary level.
(Less)
- author
- Erfurth, E M LU and Hagmar, L E LU
- publishing date
- 1995-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Aging/blood, Humans, Hypothalamo-Hypophyseal System/physiology, Male, Middle Aged, Pituitary Gland/physiology, Sex Hormone-Binding Globulin/metabolism, Testis/physiology, Testosterone/blood, Thyroid Gland/physiology, Triiodothyronine/blood
- in
- European Journal of Endocrinology
- volume
- 132
- issue
- 6
- pages
- 7 - 663
- publisher
- Society of the European Journal of Endocrinology
- external identifiers
-
- scopus:0029013359
- pmid:7788002
- ISSN
- 0804-4643
- DOI
- 10.1530/eje.0.1320663
- language
- English
- LU publication?
- no
- id
- 291c9bfd-032a-4e64-b841-7e3ef9c23965
- date added to LUP
- 2023-11-27 09:41:33
- date last changed
- 2024-01-10 11:53:00
@article{291c9bfd-032a-4e64-b841-7e3ef9c23965,
abstract = {{<p>In an attempt to study further the age-specific influence on the hypothalamo-pituitary-gonadal axis as well as the hypothalamo-pituitary-thyroid axis, we have now investigated young and middle-aged men, considering possible confounding factors. Both serum total testosterone, free testosterone and the total ratio of testosterone to sex-hormone binding globulin were significantly lower among middle-aged men as compared with young men (p = 0.02, p = 0.002 and p = 0.0003, respectively). In accordance with these findings there was also a decrease in the luteinizing hormone response to gonadotrophin-releasing hormone in the middle-aged men (p = 0.02). Free testosterone was correlated significantly with the luteinizing hormone response (r = 0.32, p = 0.02). Serum free triiodothyronine was significantly higher among young men as compared with middle-aged men (p = 0.002) and the thyrotrophin-releasing hormone-stimulated thyrotrophin response was also higher in the young group compared with the middle-aged group. The present results may indicate that the age effect on serum levels of testosterone and free triiodothyronine is mediated at the pituitary level.</p>}},
author = {{Erfurth, E M and Hagmar, L E}},
issn = {{0804-4643}},
keywords = {{Adult; Aging/blood; Humans; Hypothalamo-Hypophyseal System/physiology; Male; Middle Aged; Pituitary Gland/physiology; Sex Hormone-Binding Globulin/metabolism; Testis/physiology; Testosterone/blood; Thyroid Gland/physiology; Triiodothyronine/blood}},
language = {{eng}},
number = {{6}},
pages = {{7--663}},
publisher = {{Society of the European Journal of Endocrinology}},
series = {{European Journal of Endocrinology}},
title = {{Decreased serum testosterone and free triiodothyronine levels in healthy middle-aged men indicate an age effect at the pituitary level}},
url = {{http://dx.doi.org/10.1530/eje.0.1320663}},
doi = {{10.1530/eje.0.1320663}},
volume = {{132}},
year = {{1995}},
}