Advanced

Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation Into Cancer and Nutrition

Miller, AB; Altenburg, HP; Bueno-de-Mesquita, B; Boshuizen, HC; Agudo, A; Berrino, F; Gram, IT; Janson, L; Linseisen, J and Overvad, K, et al. (2004) In International Journal of Cancer 108(2). p.269-276
Abstract
Intake of fruits and vegetables is thought to protect against the development of lung cancer. However, some recent cohort and case-control studies have shown no protective effect. We have assessed the relation between fruit and vegetable intake and lung cancer incidence in the large prospective investigation on diet and cancer, the European Prospective Investigation Into Cancer and Nutrition (EPIC). We studied data from 478,021 individuals that took part in the EPIC study, who were recruited from 10 European countries and who completed a dietary questionnaire during 1992-1998. Follow-up was to December 1998 or 1999, but for some centres with active follow-up to June 2002. During follow-up, 1,074 participants were reported to have developed... (More)
Intake of fruits and vegetables is thought to protect against the development of lung cancer. However, some recent cohort and case-control studies have shown no protective effect. We have assessed the relation between fruit and vegetable intake and lung cancer incidence in the large prospective investigation on diet and cancer, the European Prospective Investigation Into Cancer and Nutrition (EPIC). We studied data from 478,021 individuals that took part in the EPIC study, who were recruited from 10 European countries and who completed a dietary questionnaire during 1992-1998. Follow-up was to December 1998 or 1999, but for some centres with active follow-up to June 2002. During follow-up, 1,074 participants were reported to have developed lung cancer, of whom 860 were eligible for our analysis. We used the Cox proportional hazard model to determine the effect of fruit and vegetable intake on the incidence of lung cancer. We paid particular attention to adjustment for smoking. Relative risk estimates were obtained using fruit and vegetable intake categorised by sex-specific, cohort-wide quintiles. After adjustment for age, smoking, height, weight and gender, there was a significant inverse association between fruit consumption and lung cancer risk: the hazard ratio for the highest quintile of consumption relative to the lowest being 0.60 (95% Confidence Interval 0.46-0.78), p for trend 0.0099. The association was strongest in the Northern Europe centres, and among current smokers at baseline, and was strengthened when the 293 lung cancers diagnosed in the first 2 years of follow-up were excluded from the analysis. There was no association between vegetable consumption or vegetable subtypes and lung cancer risk. The findings from this analysis can be regarded as re-enforcing recommendations with regard to enhanced fruit consumption for populations. However, the effect is likely to be small compared to smoking cessation. (Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
lung cancer, vegetables, fruits, epidemiology, cancer, diet, smoking
in
International Journal of Cancer
volume
108
issue
2
pages
269 - 276
publisher
John Wiley & Sons
external identifiers
  • pmid:14639614
  • wos:000187224600016
  • scopus:0346121350
ISSN
0020-7136
DOI
10.1002/ijc.11559
language
English
LU publication?
yes
id
a82ac37e-be13-433b-9a44-c9b9abc90b64 (old id 292917)
date added to LUP
2007-10-26 16:53:06
date last changed
2017-08-06 03:35:02
@article{a82ac37e-be13-433b-9a44-c9b9abc90b64,
  abstract     = {Intake of fruits and vegetables is thought to protect against the development of lung cancer. However, some recent cohort and case-control studies have shown no protective effect. We have assessed the relation between fruit and vegetable intake and lung cancer incidence in the large prospective investigation on diet and cancer, the European Prospective Investigation Into Cancer and Nutrition (EPIC). We studied data from 478,021 individuals that took part in the EPIC study, who were recruited from 10 European countries and who completed a dietary questionnaire during 1992-1998. Follow-up was to December 1998 or 1999, but for some centres with active follow-up to June 2002. During follow-up, 1,074 participants were reported to have developed lung cancer, of whom 860 were eligible for our analysis. We used the Cox proportional hazard model to determine the effect of fruit and vegetable intake on the incidence of lung cancer. We paid particular attention to adjustment for smoking. Relative risk estimates were obtained using fruit and vegetable intake categorised by sex-specific, cohort-wide quintiles. After adjustment for age, smoking, height, weight and gender, there was a significant inverse association between fruit consumption and lung cancer risk: the hazard ratio for the highest quintile of consumption relative to the lowest being 0.60 (95% Confidence Interval 0.46-0.78), p for trend 0.0099. The association was strongest in the Northern Europe centres, and among current smokers at baseline, and was strengthened when the 293 lung cancers diagnosed in the first 2 years of follow-up were excluded from the analysis. There was no association between vegetable consumption or vegetable subtypes and lung cancer risk. The findings from this analysis can be regarded as re-enforcing recommendations with regard to enhanced fruit consumption for populations. However, the effect is likely to be small compared to smoking cessation.},
  author       = {Miller, AB and Altenburg, HP and Bueno-de-Mesquita, B and Boshuizen, HC and Agudo, A and Berrino, F and Gram, IT and Janson, L and Linseisen, J and Overvad, K and Rasmuson, T and Vineis, P and Lukanova, A and Allen, N and Amiano, P and Barricarte, A and Berglund, Göran and Boeing, H and Clavel-Chapelon, F and Day, NE and Hallmans, G and Lund, E and Martinez, C and Navarro, C and Palli, D and Panico, S and Peeters, PHM and Quiros, JR and Tjonneland, A and Tumino, R and Trichopoulou, A and Trichopoulos, D and Slimani, N and Riboli, E},
  issn         = {0020-7136},
  keyword      = {lung cancer,vegetables,fruits,epidemiology,cancer,diet,smoking},
  language     = {eng},
  number       = {2},
  pages        = {269--276},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation Into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.11559},
  volume       = {108},
  year         = {2004},
}