Leukotriene D4-induced calcium signaling in human intestinal epithelial cells
(2002) In Advances in Experimental Medicine and Biology 507. p.91-187- Abstract
LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and... (More)
LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1.
(Less)
- author
- Thodeti, Charles Kumar and Sjölander, Anita LU
- organization
- publishing date
- 2002
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Calcium Signaling/drug effects, Humans, Intestinal Mucosa/drug effects, Leukotriene D4/pharmacology
- host publication
- Eicosanoids and other bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5
- series title
- Advances in Experimental Medicine and Biology
- editor
- Honn, K ; Marnett, L ; Nigam, S ; Dennis, E and Serhan, C
- volume
- 507
- pages
- 91 - 187
- publisher
- Springer
- external identifiers
-
- pmid:12664584
- ISSN
- 0065-2598
- ISBN
- 978-1-4615-0193-0
- DOI
- 10.1007/978-1-4615-0193-0_29
- language
- English
- LU publication?
- yes
- id
- 293bbeaf-08bc-49b5-b338-eeadb345afec
- date added to LUP
- 2019-07-03 11:23:23
- date last changed
- 2021-10-07 04:06:36
@inbook{293bbeaf-08bc-49b5-b338-eeadb345afec,
abstract = {{<p>LTD4 induces a calcium signal that consists of a mobilization from internal stores regulated by PTX-insensitive G protein, Rho, and, an influx across the plasma membrane regulated by PTX-sensitive Gi protein in human intestinal epithelial cells. The LTD4 induced mobilization of Ca2+ is mediated by a PH domain dependent association between PLC-gamma 1 and G beta gamma subunits. This interaction requires Src kinase activity as well as the association of this kinase with PLC-gamma 1, suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal. We found a cAMP-dependent protein kinase activity upstream of tyrosine kinase(s) and downstream of Gi protein, that is essential for LTD4-induced Ca2+ influx. This model of the LTD4-induced Ca2+ signaling pathways in intestinal epithelial cells is outlined schematically in Fig. 1.</p>}},
author = {{Thodeti, Charles Kumar and Sjölander, Anita}},
booktitle = {{Eicosanoids and other bioactive Lipids in Cancer, Inflammation, and Radiation Injury, 5}},
editor = {{Honn, K and Marnett, L and Nigam, S and Dennis, E and Serhan, C}},
isbn = {{978-1-4615-0193-0}},
issn = {{0065-2598}},
keywords = {{Calcium Signaling/drug effects; Humans; Intestinal Mucosa/drug effects; Leukotriene D4/pharmacology}},
language = {{eng}},
pages = {{91--187}},
publisher = {{Springer}},
series = {{Advances in Experimental Medicine and Biology}},
title = {{Leukotriene D4-induced calcium signaling in human intestinal epithelial cells}},
url = {{http://dx.doi.org/10.1007/978-1-4615-0193-0_29}},
doi = {{10.1007/978-1-4615-0193-0_29}},
volume = {{507}},
year = {{2002}},
}