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Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients

Harbo, HF; Datta, P; Oturai, A; Ryder, LP; Sawcer, S; Setakis, E; Akesson, E; Celius, EG; Modin, H and Sandberg Wollheim, Magnhild LU , et al. (2003) In Journal of Neuroimmunology 143(1-2). p.101-106
Abstract
We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens. (C) 2003 Elsevier B.V. All rights reserved.
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Contribution to journal
publication status
published
subject
keywords
Scandinavia, multiple sclerosis, genome screen, linkage disequilibrium, DNA pooling
in
Journal of Neuroimmunology
volume
143
issue
1-2
pages
101 - 106
publisher
Elsevier
external identifiers
  • pmid:14575924
  • wos:000186539300020
  • scopus:10744228501
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2003.08.021
language
English
LU publication?
yes
id
b915bd61-3b5e-4807-bebb-9bc5ed42f095 (old id 294952)
date added to LUP
2007-09-13 07:20:41
date last changed
2018-01-07 05:42:26
@article{b915bd61-3b5e-4807-bebb-9bc5ed42f095,
  abstract     = {We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens. (C) 2003 Elsevier B.V. All rights reserved.},
  author       = {Harbo, HF and Datta, P and Oturai, A and Ryder, LP and Sawcer, S and Setakis, E and Akesson, E and Celius, EG and Modin, H and Sandberg Wollheim, Magnhild and Myhr, KM and Andersen, O and Hillert, J and Sorensen, PS and Svejgaard, A and Compston, A and Vartdal, F and Spurkland, A},
  issn         = {1872-8421},
  keyword      = {Scandinavia,multiple sclerosis,genome screen,linkage disequilibrium,DNA pooling},
  language     = {eng},
  number       = {1-2},
  pages        = {101--106},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2003.08.021},
  volume       = {143},
  year         = {2003},
}